Shopping Cart
- Remove All
Your shopping cart is currently empty
MnTBAP chloride
🥰Excellent
Catalog No. T38164Cas No. 55266-18-7
Alias Mn(III)TBAP
MnTBAP chloride (Mn(III)TBAP) is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger that reduces the doubling time of SOD-E. coli by a factor of 2. MnTBAP chloride exhibits anti-inflammatory effects through upregulation of BMPR-II and inhibition of NFκB signaling. mnTBAP chloride is a manganese porphyrin complex with antioxidant properties and has potential for use in the study of fibrotic responses in chronic kidney diseases (CKDs).
MnTBAP chloride
🥰Excellent
Catalog No. T38164Alias Mn(III)TBAPCas No. 55266-18-7
MnTBAP chloride (Mn(III)TBAP) is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger that reduces the doubling time of SOD-E. coli by a factor of 2. MnTBAP chloride exhibits anti-inflammatory effects through upregulation of BMPR-II and inhibition of NFκB signaling. mnTBAP chloride is a manganese porphyrin complex with antioxidant properties and has potential for use in the study of fibrotic responses in chronic kidney diseases (CKDs).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | 32 € | In Stock | |
| 25 mg | 52 € | In Stock | |
| 50 mg | 77 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 40 € | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "MnTBAP chloride"
Diallyl disulfide
TN15762179-57-9
Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.
- 28 €
Size
QTY
L-Cystine
Cited
Cystine Acid, cystine
T2O273356-89-3
L-Cystine (Cystine Acid) is not considered one of the 20 amino acids, L-Cystine (Cystine Acid) is a sulfur-containing derivative obtained from oxidation of cysteine amino acid thiol side chains. It functions as an antioxidant and protects tissues against radiation and pollution, slowing the aging process. It also aids protein synthesis. L-Cystine (Cystine Acid) is abundant in many proteins of skeletal tissues and skin, and found in insulin and digestive enzymes chromotrypsinogen A, papain, and trypsinogen.
- 38 €
Size
QTY
CitedGlucosamine Cited
D-Glucosamine, Chitosamine
T04293416-24-8
Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to rebuild cartilage and treat arthritis.
- 47 €
Size
QTY
CitedLidocaine hydrochloride Cited
Xyloneural, Lignocaine hydrochloride, Lidothesin, Lidocaine HCL
T114473-78-9
Lidocaine hydrochloride (Lignocaine hydrochloride) is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
- 42 €
Size
QTY
CitedDiethylmaleate
Maleic acid, diethyl ester, DIETHYL MALEATE
T21480141-05-9
Diethylmaleate (Maleic acid, diethyl ester) is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.
- 38 €
Size
QTY
Indole-3-carbinol
Indole-3-Methanol, I3C, 3-Indolemethanol
T2947700-06-1
Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
- 27 €
Size
QTY
Propyl gallate
Tenox PG, n-Propyl gallate, Gallic acid propyl esterZ
T3S1866121-79-9
Propyl gallate (Gallic acid propyl esterZ) is an antioxidant used in foods especially animal fats and vegetable oils, also in a wide variety of cosmetics and beauty care products.
- 45 €
Size
QTY
Neohesperidin
NSC 31048, Hesperetin 7-O-neohesperidoside
T273713241-33-3
Neohesperidin (NSC-31048) with antioxidant and neuroprotective properties. Unlike other citrus flavanones, it does not inhibit oral carcinogenesis in a rat model.
- 37 €
Size
QTY
L-Tartaric acid
L(+)-Tartaric acid, (2R,3R)-(+)-Tartaric acid
T505987-69-4
L-Tartaric acid ((2R,3R)-(+)-Tartaric acid) occurs naturally in many plants, particularly grapes and tamarinds, and is one of the main acids found in wine. It is used as an antioxidant. Salts of tartaric acid are known as tartrates. L-Tartaric acid is a muscle toxin, which works by inhibiting the production of malic acid, and in high doses causes paralysis and death.
- 39 €
Size
QTY
Sulbutiamine
Bisibuthiamine
T59133286-46-2
Sulbutiamine (Bisibuthiamine) is an antioxidant that act by inhibiting oxidative stress induced retinal ganglion cell death.
- 27 €
Size
QTY
Thiamine monochloride
Vitamin B1, Thiamine chloride
T2O274159-43-8
Thiamine monochloride (Vitamin B1) is an essential vitamin with erythropoietic, glucose-regulatory, antioxidant, and mood-regulatory properties. It inhibits lead-induced lipid peroxidation, preventing lead poisoning, and plays a crucial role in cellular energy production from ingested food while enhancing normal neuronal activity.
- 38 €
Size
QTY
Butylated hydroxytoluene
BHT FCC/NF
T0935128-37-0
Butylated hydroxytoluene (BHT FCC/NF) is an antioxidant widely used in food, cosmetics and industrial liquids. It is a ferroptosis inhibitor.
- 31 €
Size
QTY
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | MnTBAP chloride (Mn(III)TBAP) is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger that reduces the doubling time of SOD-E. coli by a factor of 2. MnTBAP chloride exhibits anti-inflammatory effects through upregulation of BMPR-II and inhibition of NFκB signaling. mnTBAP chloride is a manganese porphyrin complex with antioxidant properties and has potential for use in the study of fibrotic responses in chronic kidney diseases (CKDs). |
| In vitro | Due to its superoxide dismutase mimetic property, 50 microM MnTBAP was found to attenuate the injury produced dose-dependently by exposure to various concentrations of paraquat for 4 h. MnTBAP also protected endothelial cells in a dose-dependent manner against paraquat. The protective effect of MnTBAP appears to be caused by its intracellular superoxide-scavenging activity because neither the zinc form nor CuZnSOD protected the cells against paraquat-induced injury.[1] |
| In vivo | Local administration of MnTBAP significantly and reduced carrageenan-induced paw oedema dose-dependently at all time points, which was related to its superoxide dismutase mimetic property. MnTBAP also caused a significant dose-dependent reduction in paw myeloperoxidase activity, as well as preventing histological injury. Immunohistochemical analyses for nitrotyrosine showed a positive staining in paw from carrageenan-treated rats.[2] |
| Alias | Mn(III)TBAP |
| Molecular Weight | 876.13 |
| Formula | C48H25ClMnN4O8 |
| Cas No. | 55266-18-7 |
| Smiles | [H+].O=C([O-])C=1C=CC(=CC1)C2=C3C=CC=4C(C=5C=CC(=CC5)C(=O)[O-])=C6C=CC7=C(C8=CC=C(C=C8)C(=O)[O-])C=9C=CC%10=C(C%11=CC=C(C=C%11)C(=O)[O-])C%12=CC=C2[N-]%12[Mn+3]([Cl-])([N]34)([N]%109)[N-]67 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90.0 mg/mL (102.4 mM), Sonication is recommended. 0.5 M NaOH: 18.0 mg/mL (20.5 mM), Sonication is recommended. 1M NaOH: 9.0 mg/mL (10.2 mM), when pH is adjusted to 8 with NaOH. Sonication is recommended. | |||||||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||||||||||||
1M NaOH/0.5 M NaOH/DMSO
0.5 M NaOH/DMSO
DMSO
| ||||||||||||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy MnTBAP chloride | purchase MnTBAP chloride | MnTBAP chloride cost | order MnTBAP chloride | MnTBAP chloride chemical structure | MnTBAP chloride in vivo | MnTBAP chloride in vitro | MnTBAP chloride formula | MnTBAP chloride molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.