HIF-1 Signaling Pathway Compound Library

Catalog No. L8500

Library Compound List Excel SDF

Cell signaling is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signaling interactions and cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated more effectively.

As a key regulator of the hypoxia response, hypoxia inducible factor-1 (HIF-1) has been attracting more attention from scientists. HIF-1 is an evolutionarily conserved transcription factor that functions as a main regulator of gene expression in response to hypoxia. HIF-1 is functionally heterodimeric, composed of HIF-1β and one of three α subunits (HIF-1α, HIF-2α, or HIF-3α). All subunits are part of the basic helix-loop-helix superfamily of transcription factors, but its activity is primarily controlled by cellular levels of the HIF-1α subunit. As a transcriptional factor, the heterodimer HIF-1 recognizes and binds to the consensus sequence 5’-(A/G) CGTG-3’ named hypoxia-responsive elements (HREs) to activate the transcriptional activity of target genes. To date, more than 100 direct target genes of HIF-1 have been uncovered, which have been shown to be functionally involved in tumor metastasis, angiogenesis, energy metabolism, cell differentiation and apoptosis.

Intensive studies have clearly established the hypoxia/HIF signaling pathway as a master regulator of the vascular system. Accordingly, it represents an important therapeutic target for vascular diseases and cancer. Pharmacologically increased HIF function may aid in the treatment of a wide range of diseases, as HIF has been shown to be essential for phenomena as diverse as immune function, cartilage formation, and wound healing. Conversely, inhibition of HIF function could also have many applications: increased levels of HIF are seen in many cancers as well as in some cardiovascular diseases, including stroke, heart attack, and pulmonary hypertension.

To meet the need of research in oxygen-sensing pathways, TargetMol collects 1352 HIF-1 related small chemicals，involving PI3K-AKT, MAPK, Ubiquitination signaling pathways and targets such as HIF, HIF Prolyl-Hydroxylase, E1/E2/E3 Enzyme, PI3K, MAPK, Proteasome, etc.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

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Product Description

A unique collection of 1352 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies；
Covers PI3K-AKT, MAPK, Ubiquitination signaling pathways and targets such as HIF, HIF Prolyl-Hydroxylase, E1/E2/E3 Enzyme, PI3K, MAPK, Proteasome, etc.
Part of them are in clinical trial phase or FDA approved；
Detailed compound information with structure, target, and biological activity description；
NMR and HPLC validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..

10. Blood. 2021, 137(11): 1478-1490. 11. Nucleic Acids Research. 2021. 12. Nature Communications. 2023, 14(1): 7574. 13. Advanced Science. 2020, 7(16): 2000925. 14. Angewandte Chemie. 2021. 15. Acta Pharmaceutica Sinica B. 2022. 16. Protein & Cell. 2021, 12(11): 877-888. 17. Bone Research. 2023, 11(1): 54. 18. Pharmacology & Therapeutics. (2021): 107930. 19. Nature Communications. 2021, 12(1): 1-12. 20. Journal of Cell Biology. 2022, 221(5): e202112024.

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Library Composition

Apoptosis (305)

Autophagy (237)

PI3K (152)

NF-κB (126)

COX (83)

Akt (82)

ERK (78)

p38 MAPK (74)

mTOR (73)

HDAC (62)

Endogenous Metabolite (60)

Raf (59)

Proteasome (56)

Ras (53)

TNF (52)

Src (47)

Antibacterial (46)

JNK (41)

MEK (40)

E1/E2/E3 Enzyme (40)

AMPK (39)

GSK-3 (39)

HIF/HIF Prolyl-Hydroxylase (36)

CDK (35)

MAPK (34)

Reactive Oxygen Species (33)

DUB (31)

IL Receptor (29)

DNA-PK (28)

S6 Kinase (28)

Ferroptosis (28)

VEGFR (28)

HIF (26)

Sirtuin (24)

TGF-beta/Smad (23)

Caspase (23)

IκB/IKK (23)

ROS (22)

Influenza Virus (21)

HIV Protease (20)

TLR (19)

p53 (19)

ATM/ATR (19)

Bcr-Abl (19)

HSP (18)

DPP-4 (18)

Mitophagy (17)

EGFR (17)

STAT (16)

Antibiotic (15)

PDGFR (15)

c-Kit (15)

PKC (15)

Parasite (14)

Mdm2 (14)

FLT (14)

Virus Protease (14)

PPAR (13)

Antioxidant (13)

Aurora Kinase (12)

MMP (12)

P450 (12)

Antifungal (12)

Interleukin (12)

Gamma-secretase (11)

JAK (11)

Rho (11)

DNA/RNA Synthesis (11)

PKA (11)

Casein Kinase (11)

FGFR (10)

PERK (10)

ALK (10)

NOD (10)

Dehydrogenase (9)

ROCK (9)

PDK (9)

Potassium Channel (8)

Beta Amyloid (8)

Lipoxygenase (8)

c-RET (8)

HSV (8)

SARS-CoV (7)

PI4K (7)

Tyrosine Kinases (7)

NO Synthase (7)

NOD-like Receptor (NLR) (7)

PDE (7)

BCL (7)

PARP (7)

IGF-1R (6)

AChE (6)

p97 (6)

MNK (6)

Serine Protease (6)

MLK (6)

Mitochondrial Metabolism (6)

Trk receptor (6)

RIP kinase (6)

TOPK (5)

NOS (5)

Xanthine Oxidase (5)

Adenosine Receptor (5)

Adrenergic Receptor (5)

Cannabinoid Receptor (5)

Tyrosinase (5)

Wnt/beta-catenin (5)

FAK (5)

Calcium Channel (5)

Glucokinase (5)

Nrf2 (4)

Phosphatase (4)

P-gp (4)

Glutathione Peroxidase (4)

Cysteine Protease (4)

ASK (4)

Chk (4)

Sodium Channel (4)

c-Fms (4)

BTK (4)

HCV Protease (4)

SGK (4)

HBV (4)

c-Met/HGFR (4)

Aryl Hydrocarbon Receptor (4)

Syk (3)

Estrogen/progestogen Receptor (3)

PTEN (3)

Proton pump (3)

Epigenetic Reader Domain (3)

Drug Metabolite (3)

Carbonic Anhydrase (3)

Topoisomerase (3)

IAP (3)

GABA Receptor (3)

Integrin (3)

SIK (3)

LRRK2 (3)

SGLT (3)

BACE (3)

TRP/TRPV Channel (3)

AChR (3)

Phospholipase (3)

PLK (3)

Antiviral (3)

AhR (2)

Chloride channel (2)

Opioid Receptor (2)

ACK (2)

Aromatase (2)

Aminopeptidase (2)

Transferase (2)

transporter (2)

PGE Synthase (2)

BMI-1 (2)

PD-1/PD-L1 (2)

Beta-Secretase (2)

IFNAR (2)

CSF-1R (2)

Glucocorticoid Receptor (2)

S1P Receptor (2)

Histamine Receptor (2)

HER (2)

Hck (2)

IRAK (2)

GTPase (2)

Serine/threonin kinase (2)

GPR (2)

KLF (2)

Leukotriene Receptor (2)

Prostaglandin Receptor (2)

Reverse Transcriptase (2)

MELK (2)

MRP (2)

DNA (2)

NEDD8 (2)

NADPH (2)

DNA Alkylation (2)

RAAS (2)

TAM Receptor (2)

Estrogen Receptor/ERR (2)

Microtubule Associated (2)

PYK2 (1)

Retinoid Receptor (1)

STING (1)

RSV (1)

Protease-activated Receptor (1)

Pyroptosis (1)

Tie-2 (1)

Thioredoxin (1)

5-HT Receptor (1)

Progesterone Receptor (1)

cell cycle arrest (1)

FLAP (1)

Fatty Acid Synthase (1)

Factor Xa (1)

FAAH (1)

Ephrin Receptor (1)

DNA Methyltransferase (1)

DNA Alkylator/Crosslinker (1)

CXCR (1)

c-Myc (1)

CFTR (1)

CCR (1)

FXR (1)

cAMP (1)

BCRP (1)

ATPase (1)

ATP Citrate Lyase (1)

Anti-infection (1)

Antifection (1)

Annexin A (1)

Androgen Receptor (1)

Amino Acids and Derivatives (1)

Adenosine deaminase (1)

Free radical scavengers (1)

Gap Junction Protein (1)

PKM (1)

LTR (1)

Pim (1)

PAK (1)

PAI-1 (1)

PAD (1)

Neprilysin (1)

NADPH-oxidase (1)

Na+/Ca2+ Exchanger (1)

Myosin (1)

Monoamine Oxidase (1)

MAO (1)

LPL Receptor (1)

Glucagon Receptor (1)

Liver X Receptor (1)

Lipase (1)

Kinesin (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

iGluR (1)

Hydroxylase (1)

Histone Acetyltransferase (1)

Guanylate cyclase (1)

GPX (1)

GluR (1)

YAP (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty