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HIF-1 Signaling Pathway Compound Library

Catalog No. L8500
  Library Compound List   Excel SDF

Cell signaling is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signaling interactions and cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated more effectively.

As a key regulator of the hypoxia response, hypoxia inducible factor-1 (HIF-1) has been attracting more attention from scientists. HIF-1 is an evolutionarily conserved transcription factor that functions as a main regulator of gene expression in response to hypoxia. HIF-1 is functionally heterodimeric, composed of HIF-1β and one of three α subunits (HIF-1α, HIF-2α, or HIF-3α). All subunits are part of the basic helix-loop-helix superfamily of transcription factors, but its activity is primarily controlled by cellular levels of the HIF-1α subunit. As a transcriptional factor, the heterodimer HIF-1 recognizes and binds to the consensus sequence 5’-(A/G) CGTG-3’ named hypoxia-responsive elements (HREs) to activate the transcriptional activity of target genes. To date, more than 100 direct target genes of HIF-1 have been uncovered, which have been shown to be functionally involved in tumor metastasis, angiogenesis, energy metabolism, cell differentiation and apoptosis.

Intensive studies have clearly established the hypoxia/HIF signaling pathway as a master regulator of the vascular system. Accordingly, it represents an important therapeutic target for vascular diseases and cancer. Pharmacologically increased HIF function may aid in the treatment of a wide range of diseases, as HIF has been shown to be essential for phenomena as diverse as immune function, cartilage formation, and wound healing. Conversely, inhibition of HIF function could also have many applications: increased levels of HIF are seen in many cancers as well as in some cardiovascular diseases, including stroke, heart attack, and pulmonary hypertension.

To meet the need of research in oxygen-sensing pathways, TargetMol collects 1352 HIF-1 related small chemicals,involving PI3K-AKT, MAPK, Ubiquitination signaling pathways and targets such as HIF, HIF Prolyl-Hydroxylase, E1/E2/E3 Enzyme, PI3K, MAPK, Proteasome, etc.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • A unique collection of 1352 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies;
  • Covers PI3K-AKT, MAPK, Ubiquitination signaling pathways and targets such as HIF, HIF Prolyl-Hydroxylase, E1/E2/E3 Enzyme, PI3K, MAPK, Proteasome, etc.
  • Part of them are in clinical trial phase or FDA approved;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L8500)

Library Composition

Apoptosis (305)
Autophagy (237)
PI3K (152)
NF-κB (126)
COX (83)
Akt (82)
ERK (78)
p38 MAPK (74)
mTOR (73)
HDAC (62)
Endogenous Metabolite (60)
Raf (59)
Proteasome (56)
Ras (53)
TNF (52)
Src (47)
Antibacterial (46)
JNK (41)
MEK (40)
E1/E2/E3 Enzyme (40)
AMPK (39)
GSK-3 (39)
HIF/HIF Prolyl-Hydroxylase (36)
CDK (35)
MAPK (34)
Reactive Oxygen Species (33)
DUB (31)
IL Receptor (29)
DNA-PK (28)
S6 Kinase (28)
Ferroptosis (28)
VEGFR (28)
HIF (26)
Sirtuin (24)
TGF-beta/Smad (23)
Caspase (23)
IκB/IKK (23)
ROS (22)
Influenza Virus (21)
HIV Protease (20)
TLR (19)
p53 (19)
ATM/ATR (19)
Bcr-Abl (19)
HSP (18)
DPP-4 (18)
Mitophagy (17)
EGFR (17)
STAT (16)
Antibiotic (15)
PDGFR (15)
c-Kit (15)
PKC (15)
Parasite (14)
Mdm2 (14)
FLT (14)
Virus Protease (14)
PPAR (13)
Antioxidant (13)
Aurora Kinase (12)
MMP (12)
P450 (12)
Antifungal (12)
Interleukin (12)
Gamma-secretase (11)
JAK (11)
Rho (11)
DNA/RNA Synthesis (11)
PKA (11)
Casein Kinase (11)
FGFR (10)
PERK (10)
ALK (10)
NOD (10)
Dehydrogenase (9)
ROCK (9)
PDK (9)
Potassium Channel (8)
Beta Amyloid (8)
Lipoxygenase (8)
c-RET (8)
HSV (8)
SARS-CoV (7)
PI4K (7)
Tyrosine Kinases (7)
NO Synthase (7)
NOD-like Receptor (NLR) (7)
PDE (7)
BCL (7)
PARP (7)
IGF-1R (6)
AChE (6)
p97 (6)
MNK (6)
Serine Protease (6)
MLK (6)
Mitochondrial Metabolism (6)
Trk receptor (6)
RIP kinase (6)
TOPK (5)
NOS (5)
Xanthine Oxidase (5)
Adenosine Receptor (5)
Adrenergic Receptor (5)
Cannabinoid Receptor (5)
Tyrosinase (5)
Wnt/beta-catenin (5)
FAK (5)
Calcium Channel (5)
Glucokinase (5)
Nrf2 (4)
Phosphatase (4)
P-gp (4)
Glutathione Peroxidase (4)
Cysteine Protease (4)
ASK (4)
Chk (4)
Sodium Channel (4)
c-Fms (4)
BTK (4)
HCV Protease (4)
SGK (4)
HBV (4)
c-Met/HGFR (4)
Aryl Hydrocarbon Receptor (4)
Syk (3)
Estrogen/progestogen Receptor (3)
PTEN (3)
Proton pump (3)
Epigenetic Reader Domain (3)
Drug Metabolite (3)
Carbonic Anhydrase (3)
Topoisomerase (3)
IAP (3)
GABA Receptor (3)
Integrin (3)
SIK (3)
LRRK2 (3)
SGLT (3)
BACE (3)
TRP/TRPV Channel (3)
AChR (3)
Phospholipase (3)
PLK (3)
Antiviral (3)
AhR (2)
Chloride channel (2)
Opioid Receptor (2)
ACK (2)
Aromatase (2)
Aminopeptidase (2)
Transferase (2)
transporter (2)
PGE Synthase (2)
BMI-1 (2)
PD-1/PD-L1 (2)
Beta-Secretase (2)
IFNAR (2)
CSF-1R (2)
Glucocorticoid Receptor (2)
S1P Receptor (2)
Histamine Receptor (2)
HER (2)
Hck (2)
IRAK (2)
GTPase (2)
Serine/threonin kinase (2)
GPR (2)
KLF (2)
Leukotriene Receptor (2)
Prostaglandin Receptor (2)
Reverse Transcriptase (2)
MELK (2)
MRP (2)
DNA (2)
NEDD8 (2)
NADPH (2)
DNA Alkylation (2)
RAAS (2)
TAM Receptor (2)
Estrogen Receptor/ERR (2)
Microtubule Associated (2)
PYK2 (1)
Retinoid Receptor (1)
STING (1)
RSV (1)
Protease-activated Receptor (1)
Pyroptosis (1)
Tie-2 (1)
Thioredoxin (1)
5-HT Receptor (1)
Progesterone Receptor (1)
cell cycle arrest (1)
FLAP (1)
Fatty Acid Synthase (1)
Factor Xa (1)
FAAH (1)
Ephrin Receptor (1)
DNA Methyltransferase (1)
DNA Alkylator/Crosslinker (1)
CXCR (1)
c-Myc (1)
CFTR (1)
CCR (1)
FXR (1)
cAMP (1)
BCRP (1)
ATPase (1)
ATP Citrate Lyase (1)
Anti-infection (1)
Antifection (1)
Annexin A (1)
Androgen Receptor (1)
Amino Acids and Derivatives (1)
Adenosine deaminase (1)
Free radical scavengers (1)
Gap Junction Protein (1)
PKM (1)
LTR (1)
Pim (1)
PAK (1)
PAI-1 (1)
PAD (1)
Neprilysin (1)
NADPH-oxidase (1)
Na+/Ca2+ Exchanger (1)
Myosin (1)
Monoamine Oxidase (1)
MAO (1)
LPL Receptor (1)
Glucagon Receptor (1)
Liver X Receptor (1)
Lipase (1)
Kinesin (1)
Indoleamine 2,3-Dioxygenase (IDO) (1)
iGluR (1)
Hydroxylase (1)
Histone Acetyltransferase (1)
Guanylate cyclase (1)
GPX (1)
GluR (1)
YAP (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE