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Capsiate
Catalog No. TN2429Cas No. 205687-01-0
Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemic, and inhibitory angiogenic activity.
Capsiate
Catalog No. TN2429Cas No. 205687-01-0
Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemic, and inhibitory angiogenic activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $73 | 7-10 days | |
| 5 mg | $189 | 7-10 days | |
| 10 mg | $289 | 7-10 days |
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Purity:96.24%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemic, and inhibitory angiogenic activity. |
| Targets&IC50 | TRPV1:290 nM(EC50) |
| In vitro | Capsiate elicits current responses in HEK293 cells expressing TRPV1[3]. Additionally, Capsiate (5 to 25 µM) inhibits Src and VEGF-induced proliferation and tube formation in human umbilical vein endothelial cells (HUVECs)[1]. |
| In vivo | Capsiate (0.03~0.54 mM; s.c.) induces nociceptive responses in mice.[3] Topical application of Capsiate reduces antigen-induced increases in ear thickness in a mouse model of passive cutaneous anaphylaxis and decreases epidermal thickness and eosinophil and mast cell infiltration in a mouse model of atopic dermatitis.[3] Capsiate (10 mg/kg) decreases body weight gain and perirenal fat weight, as well as increases oxygen consumption, fat oxidation, and carbohydrate oxidation, in a mouse model of ad libitum feeding-induced weight gain.[4] |
| Molecular Weight | 306.4 |
| Formula | C18H26O4 |
| Cas No. | 205687-01-0 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90.0 mg/mL (293.7 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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