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Harmalol hydrochloride

Catalog No. TN1724Cas No. 6028-07-5
Alias Harmidol hydrochloride

Harmalol hydrochloride (Harmidol hydrochloride) is a β-carboline alkaloid that can be extracted from the seeds of Peganum harmala L. Harmalol hydrochloride is the major metabolite of Harmaline and significantly inhibits dioxin-mediated induction of CYP1A1 at both transcriptional and post-translational levels. Harmalol hydrochloride showed vasorelaxant activity in isolated rat thoracic aortic preparations preconstricted with phenylephrine or KCl. Harmalol hydrochloride has antioxidant activity.

Harmalol hydrochloride

Harmalol hydrochloride

Purity: 100%
Catalog No. TN1724Alias Harmidol hydrochlorideCas No. 6028-07-5
Harmalol hydrochloride (Harmidol hydrochloride) is a β-carboline alkaloid that can be extracted from the seeds of Peganum harmala L. Harmalol hydrochloride is the major metabolite of Harmaline and significantly inhibits dioxin-mediated induction of CYP1A1 at both transcriptional and post-translational levels. Harmalol hydrochloride showed vasorelaxant activity in isolated rat thoracic aortic preparations preconstricted with phenylephrine or KCl. Harmalol hydrochloride has antioxidant activity.
Pack SizePriceAvailabilityQuantity
1 mg$60In Stock
5 mg$147In Stock
10 mg$218In Stock
25 mg$369In Stock
50 mg$543In Stock
100 mg$776In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Harmalol hydrochloride (Harmidol hydrochloride) is a β-carboline alkaloid that can be extracted from the seeds of Peganum harmala L. Harmalol hydrochloride is the major metabolite of Harmaline and significantly inhibits dioxin-mediated induction of CYP1A1 at both transcriptional and post-translational levels. Harmalol hydrochloride showed vasorelaxant activity in isolated rat thoracic aortic preparations preconstricted with phenylephrine or KCl. Harmalol hydrochloride has antioxidant activity.
Targets&IC50
DYRK1A:0.63 μM, H4 human glioblastoma:23.7 μM(IC50s), MAO-A:0.66 μM
In vitro
Harmalol (0.5-12.5 μM) reduces increases in the levels of the cytochrome P450 (CYP) isoform CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells and prevents TCDD-induced activation of the aryl hydrocarbon receptor (AhR) in guinea pig hepatic cytosolic extracts.[1]
Harmalol (25 μM) reduces glutamate-induced cytotoxicity, cytochrome c release, caspase-3 activation, and the production of reactive oxygen species (ROS) in PC12 cells.[2]
AliasHarmidol hydrochloride
Chemical Properties
Molecular Weight236.7
FormulaC12H13ClN2O
Cas No.6028-07-5
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90.0 mg/mL (380.2 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.2248 mL21.1238 mL42.2476 mL211.2379 mL
5 mM0.8450 mL4.2248 mL8.4495 mL42.2476 mL
10 mM0.4225 mL2.1124 mL4.2248 mL21.1238 mL
20 mM0.2112 mL1.0562 mL2.1124 mL10.5619 mL
50 mM0.0845 mL0.4225 mL0.8450 mL4.2248 mL
100 mM0.0422 mL0.2112 mL0.4225 mL2.1124 mL

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