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Dp3-Sam chloride

Dp3-Sam chloride
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Dp3-Sam chloride

Catalog No. TN1566Cas No. 53158-73-9
Dp3-Sam chloride (Delphinidin-3-sambubioside chloride) is an anthocyanin from Hibiscus acetosella (Cranberry Hibiscus) with anti-inflammatory, antioxidant, and anticancer activities.Dp3-Sam chloride inhibits LPS-induced inflammation, and inhibits LPS-induced inflammation. Dp3-Sam chloride inhibits LPS-induced inflammatory factor release, down-regulates the NF-κB pathway, and inhibits MEK1/2-ERK1/2 signaling.Dp3-Sam chloride induces apoptosis in human leukemia cells through the mitochondrial pathway mediated by reactive oxygen species.
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5 mg$6117-10 days
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Product Introduction

Bioactivity
Description
Dp3-Sam chloride (Delphinidin-3-sambubioside chloride) is an anthocyanin from Hibiscus acetosella (Cranberry Hibiscus) with anti-inflammatory, antioxidant, and anticancer activities.Dp3-Sam chloride inhibits LPS-induced inflammation, and inhibits LPS-induced inflammation. Dp3-Sam chloride inhibits LPS-induced inflammatory factor release, down-regulates the NF-κB pathway, and inhibits MEK1/2-ERK1/2 signaling.Dp3-Sam chloride induces apoptosis in human leukemia cells through the mitochondrial pathway mediated by reactive oxygen species.
In vitro
Dp3-Sam chloride (50-200 μM, 30 min) inhibits LPS-induced iNOS expression, suppresses the phosphorylation of ERK1/2 and MEK1/2, and downregulates the NF-κB signaling pathway in RAW264.7 cells[1].
Dp3-Sam chloride (24 h) inhibits HL-60 cells proliferation by inducing apoptosis (IC50 of 75 μM).[2]
Dp3-Sam chloride (100-200 µg/mL, 24 h) decreases intracellular TG levels and lipid accumulation in oleic acid-treated HepG2 cells.[2]
In vivo
Dp3-Sam chloride (15 μmol/kg; i.p.; mouse) reduced the LPS-induced paw thickness and decreased the edema by 89.3%.[1]
Dp3-Sam chloride (30 mg/kg body; oral gavage; daily for eight weeks) decreases lipid accumulation in HFD rats and decreases LPS-induced serum IL-6, MCP-1, and TNF-α levels.[3]
AliasDelphinidin-3-sambubioside chloride
Chemical Properties
Molecular Weight632.95
FormulaC26H29ClO16
Cas No.53158-73-9
Storage & Solubility Information
Storagekeep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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