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GLP-1(28-36)amide acetate

Catalog No. T37890L CAS T37890L

Synonyms: GLP-1(28-36)amide acetate(1225021-13-5 Free base)

GLP-1(28-36)amide acetate inhibits mitochondrial permeability transition with antioxidant, anti-diabetic and cardioprotection activities.

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GLP-1(28-36)amide acetate Chemical Structure

GLP-1(28-36)amide acetate, CAS T37890L

Pack Size	Availability	Price/USD
1 mg	In stock	$ 129.00
5 mg	In stock	$ 262.00
10 mg	In stock	$ 442.00
25 mg	In stock	$ 729.00
50 mg	In stock	$ 987.00
100 mg	In stock	$ 1,390.00
500 mg	In stock	$ 2,780.00
1 mL * 10 mM (in DMSO)	In stock	$ 551.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	GLP-1(28-36)amide acetate inhibits mitochondrial permeability transition with antioxidant, anti-diabetic and cardioprotection activities.
In vitro	The plasma half-life of GLP-1(28-36)amide acetate is longer in human hepatocytes (24 min) than that in mouse hepatocytes (13 min). GLP-1(28-36)amide acetate (100 nM) on hepatocytes modulates mitochondrial oxidative metabolism including gluconeogenesis in mitochondria of hepatocytes[1].
In vivo	In high-fat diet-fed mice, GLP-1(28-36)amide acetate (18.5 nmol/kg) improved hepatic glucose disposal. In diet-induced obese mice, GLP-1(28-36)amide acetate (18.5 nmol/kg BW/day) diminishes the development of hepatic steatosis. In male C57BL6/J mice, administration of GLP-1(28-36)amide acetate for 20 min to, then isolated hearts underwent 30 min of global ischemia and 40 min of reperfusion, the recovery of left ventricular developed pressure is significantly great. In a β-cell injury diabetic mouse model, GLP-1(28-36)amide acetate (18 nmol/kg; i.p.) shows cytoprotective effect on pancreatic β cells by promoting proliferation and increasing mass[1].

Synonyms	GLP-1(28-36)amide acetate(1225021-13-5 Free base)
Molecular Weight	1148.4
Formula	C56H89N15O11
CAS No.	T37890L

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11.48 mg/mL (10 mM)

References and Literature

1. Bilan Zhou, et al. GLP-1(28-36)amide, a Long Ignored Peptide Revisited. Open Biochem J. 2014 Dec 31;8:107-11.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library Anti-Obesity Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GLP-1(28-36)amide acetate T37890L GPCR/G Protein oxidation-reduction Antioxidant Glucagon Receptor GLP 1(28 36)amide acetate GLP1(2836)amide acetate GLP-1amide acetate(1225021-13-5 Free base) GLP-1(28-36)amide acetate(1225021-13-5 Free base) GLP-1amide Acetate inhibitor inhibit

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