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GLP-1(28-36)amide acetate

Catalog No. T37890L CAS T37890L

Synonyms: GLP-1(28-36)amide acetate(1225021-13-5 Free base)

GLP-1(28-36)amide acetate inhibits mitochondrial permeability transition with antioxidant, anti-diabetic and cardioprotection activities.

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GLP-1(28-36)amide acetate, CAS T37890L

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Purity: 98%

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Description	GLP-1(28-36)amide acetate inhibits mitochondrial permeability transition with antioxidant, anti-diabetic and cardioprotection activities.
In vitro	The plasma half-life of GLP-1(28-36)amide acetate is longer in human hepatocytes (24 min) than that in mouse hepatocytes (13 min). GLP-1(28-36)amide acetate (100 nM) on hepatocytes modulates mitochondrial oxidative metabolism including gluconeogenesis in mitochondria of hepatocytes[1].
In vivo	In high-fat diet-fed mice, GLP-1(28-36)amide acetate (18.5 nmol/kg) improved hepatic glucose disposal. In diet-induced obese mice, GLP-1(28-36)amide acetate (18.5 nmol/kg BW/day) diminishes the development of hepatic steatosis. In male C57BL6/J mice, administration of GLP-1(28-36)amide acetate for 20 min to, then isolated hearts underwent 30 min of global ischemia and 40 min of reperfusion, the recovery of left ventricular developed pressure is significantly great. In a β-cell injury diabetic mouse model, GLP-1(28-36)amide acetate (18 nmol/kg; i.p.) shows cytoprotective effect on pancreatic β cells by promoting proliferation and increasing mass[1].

Synonyms	GLP-1(28-36)amide acetate(1225021-13-5 Free base)
Molecular Weight	1148.4
Formula	C56H89N15O11
CAS No.	T37890L

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Bilan Zhou, et al. GLP-1(28-36)amide, a Long Ignored Peptide Revisited. Open Biochem J. 2014 Dec 31;8:107-11.

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Keywords

GLP-1(28-36)amide acetate T37890L GPCR/G Protein oxidation-reduction Antioxidant Glucagon Receptor GLP 1(28 36)amide acetate GLP-1(28-36)amide acetate(1225021-13-5 Free base) GLP1(2836)amide acetate Inhibitor inhibitor inhibit

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