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Anti-Obesity Compound Library

Catalog No. L7100
  Library Compound List   Excel SDF

Obesity has become the public health issue of the day—and for good reason. The data outline a dismal picture and a more foreboding future. The prevalence of obesity has doubled in adults and children and tripled in adolescents over the past 2 decades. Two thirds of Americans are overweight or obese. Each year in the United States, 400 000 deaths and $117 billion in health-care and related costs are attributable to obesity. Obesity is a complex, multi-factorial disease that develops from the interaction of genetic, social, behavioral, cultural, physiological, and metabolic factors. It is intimately linked to heart disease, sleep apnea, and certain cancers. Current main options for treatment of obesity including diet, physical exercise, behavioral therapy, and bariatric surgery have some degree of risk. Therefore, there is a strong need to develop a new effective and safe anti-obesity drug.Many pharmaceutical companies have invested substantial capital and labor to develop anti-obesity drugs; however, most of the anti-obesity drugs that have thus far been approved and marketed have ultimately been withdrawn because of their serious adverse effects. Scientists are trying to find and identify safe and effective anti-obesity bioactive ingredients from food or drugs, especially by inhibiting intestinal fat absorption, increasing fat cell metabolism, and enhancing the energy expenditure, such as lipase inhibitors, alpha-glucosidase inhibitors (αGI), and Maltase‐glucoamylase (MGA) inhibitors.

Traditional pharmacological monotherapies for obesity, although initially successful in achieving weight loss, are often subject to counter-regulation. This is not surprising given the multiplicity and redundancy of mechanisms involved in appetite regulation and energy homeostasis. It is therefore pertinent to note that combination agents that are designed to simultaneously target more than one biological mechanism might ultimately be more effective in producing sustained weight loss and improvements in comorbidities.

Based on the published literature, TargetMol carefully collects 1359 compounds with anti-obesity activity as Anti-Obesity Compound Library, which can be used for anti-obesity research and drug discovery.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • A unique collection of 1359 anti-obesity compounds for high throughput and high content screening;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L7100)

Library Composition

PI3K (132)
PPAR (85)
mTOR (65)
ERK (64)
Akt (57)
p38 MAPK (55)
Raf (54)
AMPK (51)
ROS (50)
VEGFR (41)
GSK-3 (41)
NF-κB (39)
COX (36)
Lipoxygenase (36)
MEK (35)
CDK (35)
Wnt/beta-catenin (34)
JNK (33)
JAK (33)
Adrenergic Receptor (32)
DNA-PK (31)
Phospholipase (30)
PDGFR (25)
Ras (24)
MAPK (23)
Autophagy (23)
ATM/ATR (23)
S6 Kinase (22)
Src (21)
Apoptosis (18)
FAAH (17)
c-Kit (16)
Endogenous Metabolite (16)
FLT (16)
Antioxidant (16)
TNF (15)
Fatty Acid Synthase (14)
PDK (13)
SGLT (12)
IL Receptor (12)
PKC (12)
Tyrosine Kinases (12)
Lipase (11)
MMP (11)
FGFR (11)
STAT (11)
c-RET (11)
5-HT Receptor (11)
Caspase (11)
Aurora Kinase (10)
P450 (10)
PKA (10)
Cannabinoid Receptor (10)
DNA/RNA Synthesis (9)
Bcr-Abl (9)
AChR (9)
Rho (9)
Potassium Channel (8)
transporter (8)
ALK (8)
c-Met/HGFR (7)
Casein Kinase (7)
EGFR (7)
Glucokinase (7)
Chk (6)
MLK (6)
Estrogen/progestogen Receptor (6)
Serine Protease (5)
HIV Protease (5)
Antiviral (5)
PDE (5)
Antibacterial (5)
Dopamine Receptor (5)
TGF-beta/Smad (5)
CETP (5)
Vitamin (5)
Dehydrogenase (5)
Trk receptor (5)
HIF (5)
MNK (5)
BCL (4)
Histamine Receptor (4)
Proton pump (4)
Nrf2 (4)
IGF-1R (4)
Antifection (4)
ASK (4)
Mitochondrial Metabolism (4)
IκB/IKK (4)
Antifungal (4)
PARP (4)
PTEN (4)
NADPH (4)
Carbonic Anhydrase (4)
Tyrosinase (4)
Sirtuin (4)
SIK (4)
Glucagon Receptor (4)
RAAS (3)
GABA Receptor (3)
NPC1L1 (3)
DNA Alkylation (3)
ATP Citrate Lyase (3)
TOPK (3)
c-Fms (3)
p53 (3)
MELK (3)
LRRK2 (3)
NO Synthase (3)
NOS (3)
LDL (3)
Calcium Channel (3)
Prostaglandin Receptor (3)
Antibiotic (3)
GPCR19 (3)
Acyltransferase (2)
Reactive Oxygen Species (2)
ACK (2)
Retinoid Receptor (2)
Transferase (2)
ROCK (2)
Porcupine (2)
Thyroid hormone receptor(THR) (2)
PERK (2)
PLK (2)
Syk (2)
SGK (2)
Parasite (2)
Adiponectin receptor (2)
AhR (2)
PI4K (2)
Aromatase (2)
Integrin (2)
ATPase (2)
MAO (2)
GPR (2)
HDAC (2)
Glutathione reductase (2)
Glucocorticoid Receptor (2)
HSP (2)
FAK (2)
Epigenetic Reader Domain (2)
GTPase (2)
Ephrin Receptor (2)
LTR (2)
MAGL (2)
Lipid (2)
Microtubule Associated (2)
BACE (2)
Neuropeptide Y Receptor (2)
NADPH-oxidase (2)
Cysteine Protease (2)
MPO (2)
CSF-1R (2)
DYRK (1)
Somatostatin (1)
Androgen Receptor (1)
S1P Receptor (1)
GPX (1)
cholecystokinin (1)
GluR (1)
FXR (1)
Sodium Channel (1)
Adenosine Receptor (1)
Free radical scavengers (1)
E1/E2/E3 Enzyme (1)
Ferroptosis (1)
UGT (1)
Thrombin (1)
Tie-2 (1)
TLR (1)
DHFR (1)
TRP/TRPV Channel (1)
CFTR (1)
DNA (1)
Topoisomerase (1)
GST (1)
RAR/RXR (1)
ribosome (1)
BTK (1)
Norepinephrine (1)
Opioid Receptor (1)
Monocarboxylate transporter (1)
OX Receptor (1)
OXPHOS (1)
Oxytocin Receptor (1)
Mitophagy (1)
PAFR (1)
PAI-1 (1)
PAK (1)
Beta Amyloid (1)
Arginase (1)
P-gp (1)
BMI-1 (1)
ABC (1)
Reverse Transcriptase (1)
Immunology & Inflammation related (1)
CaMK (1)
IAP (1)
Hydroxylase (1)
HSV (1)
Histone Methyltransferase (1)
Histone Acetylation (1)
HIF/HIF Prolyl-Hydroxylase (1)
PYK2 (1)
Hedgehog/Smoothened (1)
NOD (1)
Annexin A (1)
HCV Protease (1)
Hck (1)
c-Myc (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE