Anti-Obesity Compound Library

Catalog No. L7100

Library Compound List Excel SDF

Obesity has become the public health issue of the day—and for good reason. The data outline a dismal picture and a more foreboding future. The prevalence of obesity has doubled in adults and children and tripled in adolescents over the past 2 decades. Two thirds of Americans are overweight or obese. Each year in the United States, 400 000 deaths and $117 billion in health-care and related costs are attributable to obesity. Obesity is a complex, multi-factorial disease that develops from the interaction of genetic, social, behavioral, cultural, physiological, and metabolic factors. It is intimately linked to heart disease, sleep apnea, and certain cancers. Current main options for treatment of obesity including diet, physical exercise, behavioral therapy, and bariatric surgery have some degree of risk. Therefore, there is a strong need to develop a new effective and safe anti-obesity drug.Many pharmaceutical companies have invested substantial capital and labor to develop anti-obesity drugs; however, most of the anti-obesity drugs that have thus far been approved and marketed have ultimately been withdrawn because of their serious adverse effects. Scientists are trying to find and identify safe and effective anti-obesity bioactive ingredients from food or drugs, especially by inhibiting intestinal fat absorption, increasing fat cell metabolism, and enhancing the energy expenditure, such as lipase inhibitors, alpha-glucosidase inhibitors (αGI), and Maltase‐glucoamylase (MGA) inhibitors.

Traditional pharmacological monotherapies for obesity, although initially successful in achieving weight loss, are often subject to counter-regulation. This is not surprising given the multiplicity and redundancy of mechanisms involved in appetite regulation and energy homeostasis. It is therefore pertinent to note that combination agents that are designed to simultaneously target more than one biological mechanism might ultimately be more effective in producing sustained weight loss and improvements in comorbidities.

Based on the published literature, TargetMol carefully collects 2286 compounds with anti-obesity activity as Anti-Obesity Compound Library, which can be used for anti-obesity research and drug discovery.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

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please contact our compound library specialist for a customized compound library at inquiry@targetmol.com

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Product Description

A unique collection of 2286 anti-obesity compounds for high throughput and high content screening;
Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
Structurally diverse, medicinally active, and cell permeable;
NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..

10. Blood. 2021, 137(11): 1478-1490. 11. Nucleic Acids Research. 2021. 12. Nature Communications. 2023, 14(1): 7574. 13. Advanced Science. 2020, 7(16): 2000925. 14. Angewandte Chemie. 2021. 15. Acta Pharmaceutica Sinica B. 2022. 16. Protein & Cell. 2021, 12(11): 877-888. 17. Bone Research. 2023, 11(1): 54. 18. Pharmacology & Therapeutics. (2021): 107930. 19. Nature Communications. 2021, 12(1): 1-12. 20. Journal of Cell Biology. 2022, 221(5): e202112024.

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Library Composition

Apoptosis (313)

Autophagy (296)

PI3K (193)

Reactive Oxygen Species (150)

Endogenous Metabolite (146)

5-HT Receptor (135)

Adrenergic Receptor (120)

PPAR (119)

mTOR (104)

ERK (100)

p38 MAPK (98)

Akt (96)

Antibacterial (89)

NF-κB (88)

Dopamine Receptor (85)

Histamine Receptor (85)

AMPK (81)

Raf (74)

GSK-3 (73)

Ras (64)

COX (61)

Wnt/beta-catenin (53)

MAPK (51)

VEGFR (51)

ROS (51)

CDK (50)

JNK (50)

MEK (48)

Phospholipase (43)

Lipoxygenase (42)

AChR (42)

JAK (41)

PKA (39)

Nrf2 (38)

DNA-PK (38)

Parasite (38)

TGF-beta/Smad (37)

Ferroptosis (36)

TNF (35)

Influenza Virus (34)

S6 Kinase (33)

Prostaglandin Receptor (31)

Antifungal (31)

P450 (31)

PDGFR (29)

Fatty Acid Synthase (29)

Src (29)

Antioxidant (29)

PKC (28)

Antibiotic (28)

GPR (26)

ALK (26)

Potassium Channel (25)

ATM/ATR (24)

IL Receptor (23)

Calcium Channel (23)

FLT (23)

Caspase (23)

HIV Protease (23)

STAT (22)

Mitophagy (21)

FAAH (20)

PDE (20)

c-Kit (19)

Dehydrogenase (19)

DNA/RNA Synthesis (19)

Virus Protease (18)

PDK (18)

Norepinephrine (18)

Adenosine Receptor (18)

Cannabinoid Receptor (18)

Serotonin Transporter (18)

MMP (17)

Casein Kinase (17)

Opioid Receptor (17)

Hedgehog/Smoothened (17)

FGFR (17)

Aurora Kinase (16)

PI4K (16)

Lipase (15)

NO Synthase (15)

PARP (15)

SGLT (14)

Tyrosine Kinases (14)

AChE (13)

Rho (13)

Glucagon Receptor (13)

Transferase (12)

BCL (12)

ROCK (12)

c-RET (12)

HIF/HIF Prolyl-Hydroxylase (11)

Tyrosinase (11)

Estrogen/progestogen Receptor (11)

Bcr-Abl (11)

EGFR (11)

Stearoyl-CoA Desaturase (SCD) (11)

transporter (11)

Acetyl-CoA Carboxylase (11)

CaMK (10)

Mitochondrial Metabolism (10)

c-Met/HGFR (10)

TRP/TRPV Channel (10)

CXCR (10)

IκB/IKK (10)

ROS Kinase (9)

Interleukin (9)

Trk receptor (9)

Smo (9)

MLK (9)

Glucosidase (8)

Sodium Channel (8)

P-gp (8)

HDAC (8)

Melanocortin Receptor (8)

IGF-1R (8)

Chk (8)

DYRK (8)

MNK (7)

PTEN (7)

HSV (7)

GABA Receptor (7)

OX Receptor (7)

S1P Receptor (7)

Glucocorticoid Receptor (7)

SIK (7)

Phosphatase (7)

Leukotriene Receptor (7)

LPL Receptor (7)

Topoisomerase (7)

NOS (7)

HBV (6)

Epigenetic Reader Domain (6)

Serine/threonin kinase (6)

Antiviral (6)

Acyltransferase (6)

Sirtuin (6)

Anti-infection (6)

Syk (6)

Xanthine Oxidase (6)

CETP (6)

Beta Amyloid (6)

c-Fms (6)

MELK (6)

PAFR (6)

Microtubule Associated (6)

P2Y Receptor (6)

Drug Metabolite (6)

SARS-CoV (5)

SGK (5)

RAAS (5)

FAK (5)

TOPK (5)

Sigma receptor (5)

Histone Methyltransferase (5)

Antifection (5)

Serine Protease (5)

LTR (5)

Free radical scavengers (5)

HER (5)

Neurokinin receptor (5)

ATPase (5)

Annexin A (5)

Proton pump (5)

ASK (5)

HIF (5)

MAO (5)

Endothelin Receptor (5)

Protease-activated Receptor (5)

Estrogen Receptor/ERR (5)

TLR (4)

HCV Protease (4)

Integrin (4)

GPCR19 (4)

Carbonic Anhydrase (4)

Porcupine (4)

p53 (4)

Monoamine Oxidase (4)

NPC1L1 (4)

Glutathione Peroxidase (4)

PLK (4)

Melatonin Receptor (4)

Pim (4)

LDL (4)

NADPH (4)

PERK (4)

CaSR (4)

iGluR (4)

GluR (4)

Aryl Hydrocarbon Receptor (4)

cAMP (4)

Reverse Transcriptase (3)

UGT (3)

Myosin (3)

Neuropeptide Y Receptor (3)

Chloride channel (3)

MAGL (3)

Adiponectin receptor (3)

GRK (3)

Retinoid Receptor (3)

MRP (3)

FXR (3)

PGE Synthase (3)

ABC (3)

HSP (3)

GTPase (3)

KLF (3)

cholecystokinin (3)

ATP Citrate Lyase (3)

Reductase (3)

BACE (3)

NADPH-oxidase (2)

CRISPR/Cas9 (2)

Aromatase (2)

Thyroid hormone receptor(THR) (2)

GST (2)

IAP (2)

DNA Alkylation (2)

Guanylate cyclase (2)

NMDAR (2)

MT Receptor (2)

Gamma-secretase (2)

RIP kinase (2)

Immunology/Inflammation related (2)

CSF-1R (2)

Cysteine Protease (2)

Melanin-concentrating Hormone Receptor (MCHR) (2)

GNRH Receptor (2)

c-Myc (2)

Tie-2 (2)

RAR/RXR (2)

YAP (2)

ROR (2)

Monocarboxylate transporter (2)

Apelin receptor (2)

Proteasome (2)

PAK (2)

E1/E2/E3 Enzyme (2)

Glutathione reductase (2)

ACK (2)

Lipid (2)

Androgen Receptor (2)

DNA (2)

Ephrin Receptor (2)

Beta-Secretase (2)

LRRK2 (2)

RSV (2)

Histone Demethylase (1)

Arginase (1)

Progesterone Receptor (1)

Na+/Ca2+ Exchanger (1)

Thrombin (1)

STING (1)

lysosomal autophagy (1)

Histone Acetyltransferase (1)

Oxytocin Receptor (1)

MyD88 (1)

GPX (1)

IRAK (1)

CFTR (1)

DHFR (1)

FKBP (1)

Imidazoline Receptor (1)

PD-1/PD-L1 (1)

Mdm2 (1)

PAI-1 (1)

Kinesin (1)

AhR (1)

NOD (1)

DNA Methyltransferase (1)

Hippo pathway (1)

Vasopressin Receptor (1)

CCR (1)

Hydroxylase (1)

PGC-1α (1)

PAD (1)

Epoxide Hydrolase (1)

DPP-4 (1)

Monoamine Transporter (1)

BTK (1)

BCRP (1)

FLAP (1)

BMI-1 (1)

Gap Junction Protein (1)

DAPK (1)

Discoidin Domain Receptor (DDR) (1)

Platelet aggregation (1)

LPA Receptor (1)

ribosome (1)

OXPHOS (1)

PYK2 (1)

Glucokinase (1)

Somatostatin (1)

Bradykinin Receptor (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty