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GLP-1(32-36)amide

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Catalog No. T37891Cas No. 1417302-71-6

GLP-1(32-36)amide is a pentapeptide compound derived from the C terminus of the glucoregulatory hormone GLP-1. This compound has shown potential in inhibiting weight gain and regulating glucose metabolism in diabetic mice[1][2].

GLP-1(32-36)amide
Other Forms of GLP-1(32-36)amide:

GLP-1(32-36)amide

🥰Excellent
Catalog No. T37891Cas No. 1417302-71-6
GLP-1(32-36)amide is a pentapeptide compound derived from the C terminus of the glucoregulatory hormone GLP-1. This compound has shown potential in inhibiting weight gain and regulating glucose metabolism in diabetic mice[1][2].
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Product Introduction

Bioactivity
Description
GLP-1(32-36)amide is a pentapeptide compound derived from the C terminus of the glucoregulatory hormone GLP-1. This compound has shown potential in inhibiting weight gain and regulating glucose metabolism in diabetic mice[1][2].
In vitro
GLP-1(32-36)amide (0.1-10 μM; 24 h) maintains cell viability and reduces apoptosis in INS‐1 cells treated with Streptozotocin (STZ; 1 μM) [2].
In vivo
GLP-1(32-36)amide (1 μmol/kg; i.p. once daily for 21 days) protects islets from damage, inhibits weight gain, and alleviates polydipsia symptoms in diabetic mice[2]. A single dose of GLP-1(32-36)amide (1 μmol/kg; i.p.) slightly reduces mean glucose levels 30 minutes post-glucose challenge in normal mice[2]. GLP-1(32-36)amide (50-70 nmol/kg/d; infusion for 12-16 weeks) prevents diet-induced obesity and hepatic steatosis in high-fat-fed mice[3].

Animal Model: Male KM mice (6-8 weeks; 18-22 g) injected with STZ[2].
Chemical Properties
Molecular Weight570.74
FormulaC25H50N10O5
Cas No.1417302-71-6
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 250 mg/mL (438.04 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7521 mL8.7606 mL17.5211 mL87.6056 mL
5 mM0.3504 mL1.7521 mL3.5042 mL17.5211 mL
10 mM0.1752 mL0.8761 mL1.7521 mL8.7606 mL
20 mM0.0876 mL0.4380 mL0.8761 mL4.3803 mL
50 mM0.0350 mL0.1752 mL0.3504 mL1.7521 mL
100 mM0.0175 mL0.0876 mL0.1752 mL0.8761 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

GLP1(3236)amideGLP 1(32 36)amideGLP-1amide
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