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Bryonolic acid
🥰Excellent
Catalog No. T19882Cas No. 24480-45-3
Alias UNII-J7YR6A878I, 20-epi-Bryonolic acid
Bryonolic acid (20-epi-Bryonolic acid), a triterpenoid extracted from Sandoricum indicum, possesses immunomodulatory, anti-inflammatory, antioxidant and anticancer activities and protects PC12 cells from NMDA-induced apoptosis by inhibiting Ca2+ in-flux and modulating gene expression in the Ca2+-CaMKII-CREB signalling pathway.
Bryonolic acid
🥰Excellent
Purity: 99.93%
Catalog No. T19882Alias UNII-J7YR6A878I, 20-epi-Bryonolic acidCas No. 24480-45-3
Bryonolic acid (20-epi-Bryonolic acid), a triterpenoid extracted from Sandoricum indicum, possesses immunomodulatory, anti-inflammatory, antioxidant and anticancer activities and protects PC12 cells from NMDA-induced apoptosis by inhibiting Ca2+ in-flux and modulating gene expression in the Ca2+-CaMKII-CREB signalling pathway.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $316 | In Stock | |
| 2 mg | $468 | In Stock | |
| 5 mg | $769 | In Stock |
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Purity:99.93%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Bryonolic acid (20-epi-Bryonolic acid), a triterpenoid extracted from Sandoricum indicum, possesses immunomodulatory, anti-inflammatory, antioxidant and anticancer activities and protects PC12 cells from NMDA-induced apoptosis by inhibiting Ca2+ in-flux and modulating gene expression in the Ca2+-CaMKII-CREB signalling pathway. |
| Targets&IC50 | M2 mAChR:7.78 (pKi), M1 mAChR:7.08 (pKi), H1 Receptor:7.48 (pA2), mAChR4:7.00 (pKi), M3 mAChR:6.70 (pKi) |
| In vitro | In the presence of three elicitors (methyl jasmonate, yeast extract, and chitosan), cell suspensions treated with 1 mg/mL of chitosan for eight days led to higher bryonolic acid contents (23.56 ± 1.68 mg/g dry weight),cell culture and root extracts with high bryonolic acid contents resulted in significantly higher percent cell viabilities than those observed under control (1% v/v DMSO) treatment in Saos-2 and MCF-7 cells[1]. Bryonolic acid inhibits ACAT in intact cancer cells with an IC50 of 12.6 ± 2.4 µM.Bryonolic acid inhibited both clonogenicity and invasiveness of several cancer cell lines[2]. |
| In vivo | Treatment with 500 mg/kg Bryonolic acid or vehicle by intraperitoneal injection in Nrf2 wild-type or Nrf2 knockout mice revealed that Bryonolic acid effectively induced HO-1 in a manner dependent on the Nrf2-Keap1 pathway[3]. |
| Alias | UNII-J7YR6A878I, 20-epi-Bryonolic acid |
| Molecular Weight | 456.7 |
| Formula | C30H48O3 |
| Cas No. | 24480-45-3 |
| Smiles | C[C@@]12[C@](C)([C@]3([C@@](C)(CC1)CC[C@@](C(O)=O)(C)C3)[H])CCC4=C2CC[C@@]5([C@]4(C)CC[C@H](O)C5(C)C)[H] |
| Relative Density. | 1.10 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | DMSO: 1 mg/mL (2.19 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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