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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
5 mg | $63 | In Stock | |
10 mg | $90 | In Stock | |
25 mg | $147 | In Stock | |
50 mg | $215 | In Stock | |
100 mg | $318 | In Stock | |
500 mg | $773 | In Stock | |
1 mL x 10 mM (in DMSO) | $98 | In Stock |
Description | Isoliensinine (Isoliensinin) is a natural product, a bisbenzylisoquinoline alkaloid. Isoliensinine has antitumor, antioxidant, anti-inflammatory, and antiarrhythmic activities. |
In vitro | METHODS: Human breast cancer cells MDA-MB-231 were treated with Isoliensinine (1-40 µM) for 24-72 h. Cell viability was measured by CCK-8 Assay. RESULTS: Isoliensinine exhibited anticancer properties in MDA-MB-231 cells, with estimated IC50 values of 108.1 µM, 22.78 µM, and 18.34 µM at 24 h, 48 h, and 72 h, respectively. [1] METHODS: Cervical cancer cells C33A, Caski, HeLa and SiHa were treated with Isoliensinine (5-40 µM) for 24 h. The expression levels of target proteins were detected by Western Blot. RESULTS: Isoliensinine significantly reduced CDK2 and cyclin E at the protein level in a dose-dependent manner in the four cervical cancer cells. [2] |
In vivo | METHODS: To investigate the effects on pulmonary fibrosis in mice, Isoliensinine (10-40 mg/kg) was orally administered three times daily for 14 days to Kungming mice with bleomycin (BLM)-induced pulmonary fibrosis. RESULTS: Isoliensinine exerted a significant inhibitory effect on BLM-induced pulmonary fibrosis, which may be due to its antioxidant and/or anti-inflammatory activity as well as inhibition of BLM-induced overexpression of TNF-α and TGF-β1. [3] |
Alias | Isoliensinin |
Molecular Weight | 610.74 |
Formula | C37H42N2O6 |
Cas No. | 6817-41-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble DMSO: 55 mg/mL (90.05 mM) ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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