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Isoliensinine
🥰Excellent
Catalog No. T5S1103Cas No. 6817-41-0
Alias Isoliensinin
Isoliensinine (Isoliensinin) is a natural product, a bisbenzylisoquinoline alkaloid. Isoliensinine has antitumor, antioxidant, anti-inflammatory, and antiarrhythmic activities.
Isoliensinine
🥰Excellent
Purity: 99.04%
Catalog No. T5S1103Alias IsoliensininCas No. 6817-41-0
Isoliensinine (Isoliensinin) is a natural product, a bisbenzylisoquinoline alkaloid. Isoliensinine has antitumor, antioxidant, anti-inflammatory, and antiarrhythmic activities.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 5 mg | $63 | In Stock | |
| 10 mg | $90 | In Stock | |
| 25 mg | $147 | In Stock | |
| 50 mg | $215 | In Stock | |
| 100 mg | $318 | In Stock | |
| 500 mg | $773 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $98 | In Stock |
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Purity:99.04%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Isoliensinine (Isoliensinin) is a natural product, a bisbenzylisoquinoline alkaloid. Isoliensinine has antitumor, antioxidant, anti-inflammatory, and antiarrhythmic activities. |
| In vitro | METHODS: Human breast cancer cells MDA-MB-231 were treated with Isoliensinine (1-40 µM) for 24-72 h. Cell viability was measured by CCK-8 Assay. RESULTS: Isoliensinine exhibited anticancer properties in MDA-MB-231 cells, with estimated IC50 values of 108.1 µM, 22.78 µM, and 18.34 µM at 24 h, 48 h, and 72 h, respectively. [1] METHODS: Cervical cancer cells C33A, Caski, HeLa and SiHa were treated with Isoliensinine (5-40 µM) for 24 h. The expression levels of target proteins were detected by Western Blot. RESULTS: Isoliensinine significantly reduced CDK2 and cyclin E at the protein level in a dose-dependent manner in the four cervical cancer cells. [2] |
| In vivo | METHODS: To investigate the effects on pulmonary fibrosis in mice, Isoliensinine (10-40 mg/kg) was orally administered three times daily for 14 days to Kungming mice with bleomycin (BLM)-induced pulmonary fibrosis. RESULTS: Isoliensinine exerted a significant inhibitory effect on BLM-induced pulmonary fibrosis, which may be due to its antioxidant and/or anti-inflammatory activity as well as inhibition of BLM-induced overexpression of TNF-α and TGF-β1. [3] |
| Alias | Isoliensinin |
| Molecular Weight | 610.74 |
| Formula | C37H42N2O6 |
| Cas No. | 6817-41-0 |
| Smiles | COc1ccc(CC2N(C)CCc3cc(OC)c(Oc4cc(CC5N(C)CCc6cc(OC)c(O)cc56)ccc4O)cc23)cc1 |
| Relative Density. | 1.218 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble DMSO: 55 mg/mL (90.05 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5.5 mg/mL (9.01 mM), In vivo: Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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