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Neophytadiene
🥰Excellent
Catalog No. T40586Cas No. 504-96-1
Neophytadiene is a diterpene compound extracted from Turbinaria ornate, with anti-inflammatory, antidepressant, anxiolytic-like, anticonvulsant, antioxidant, and cardioprotective effects. It inhibits LPS-induced inflammation in RAW 264.7 macrophages and Sprague-Dawley rats and can be used in neurological disease research.
Neophytadiene
🥰Excellent
Catalog No. T40586Cas No. 504-96-1
Neophytadiene is a diterpene compound extracted from Turbinaria ornate, with anti-inflammatory, antidepressant, anxiolytic-like, anticonvulsant, antioxidant, and cardioprotective effects. It inhibits LPS-induced inflammation in RAW 264.7 macrophages and Sprague-Dawley rats and can be used in neurological disease research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $52 | In Stock | |
| 5 mg | $129 | In Stock | |
| 10 mg | $217 | In Stock | |
| 25 mg | $390 | In Stock | |
| 50 mg | $585 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Neophytadiene is a diterpene compound extracted from Turbinaria ornate, with anti-inflammatory, antidepressant, anxiolytic-like, anticonvulsant, antioxidant, and cardioprotective effects. It inhibits LPS-induced inflammation in RAW 264.7 macrophages and Sprague-Dawley rats and can be used in neurological disease research. |
| In vitro | Neophytadiene has an IC50 value of 50 μM for RAW 264.7 cells. Neophytadiene (25, 50, and 100 μM) pretreated LPS-induced RAW 264.7 cells to inhibit NO production and down-regulate the production of inducable nitric oxide synthase (iNOS). Neophytadiene (25, 50, and 100 μM) significantly reduced the production of TNF-α and NF-κB proteins in LPS-induced cells. [1] |
| In vivo | Neophytadiene (12, 25, and 50 mg/kg, orally administered once daily for 7 days) showed that Neophytadiene improved CKMB levels in LPS treated rats in a dose-dependent manner. Restores SOD and catalase activity and reduces levels of pro-inflammatory cytokines such as IL1β, IL6 and IL10. [1] |
| Molecular Weight | 278.52 |
| Formula | C20H38 |
| Cas No. | 504-96-1 |
| Smiles | C=CC(=C)CCCC(C)CCCC(C)CCCC(C)C |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (17.95 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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