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6,4'-Dihydroxy-7-methoxyflavanone
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Catalog No. TN3144Cas No. 189689-32-5
6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae) with antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in studies about the treatment of osteoclastogenic bone diseases such osteoporosis, rheumatoid arthritis and periodontal diseases.
6,4'-Dihydroxy-7-methoxyflavanone
😃Good
Catalog No. TN3144Cas No. 189689-32-5
6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae) with antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in studies about the treatment of osteoclastogenic bone diseases such osteoporosis, rheumatoid arthritis and periodontal diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 230 € | Backorder |
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Product Introduction
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Chemical Properties
| Description | 6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae) with antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in studies about the treatment of osteoclastogenic bone diseases such osteoporosis, rheumatoid arthritis and periodontal diseases. |
| In vitro | 6,4'-Dihydroxy-7-methoxyflavanone showed inhibition of osteoclasts differentiation and function. 6,4'-Dihydroxy-7-methoxyflavanone increased cellular resistance to oxidative injury caused by glutamate-induced cytotoxicity in HT22 cells, via JUN N-terminal kinase (JNK) pathway dependent (HO)-1 expression. 6,4'-Dihydroxy-7-methoxyflavanone suppressed the lipopolysaccharide (LPS)-induced expression of pro-inflammatory enzymes and inflammatory mediators in BV2 microglia. 6,4'-Dihydroxy-7-methoxyflavanone suppressed production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), through extracellular signal-regulated kinase (ERK) pathway dependent HO-1 expression. CONCLUSIONS: This study indicates that 6,4'-Dihydroxy-7-methoxyflavanone effectively modulates the regulation of anti-oxidative and anti-inflammatory action, via up-regulation of HO-1 in HT22 cells and BV2 microglia. 6,4'-Dihydroxy-7-methoxyflavanone possesses therapeutic potentials against neurodegenerative diseases that are induced by oxidative stress and neuroinflammation[1]. |
| Molecular Weight | 286.28 |
| Formula | C16H14O5 |
| Cas No. | 189689-32-5 |
| Smiles | O=C1C2=CC(O)=C(OC)C=C2OC(C3=CC=C(O)C=C3)C1 |
| Relative Density. | 1.370 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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