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Pheophorbide a
🥰Excellent
Catalog No. T36430Cas No. 15664-29-6
Pheophorbide A is a photosensitizer used in in vivo photodynamic therapy (PDT).Phoophorbide A is a lymphatic vasoreactivator with antioxidant, anti-inflammatory, antitumor, and hypoglycemic activities.Phoophorbide A is used in research on diabetes and cancer.
Pheophorbide a
🥰Excellent
Purity: 95.03%
Catalog No. T36430Cas No. 15664-29-6
Pheophorbide A is a photosensitizer used in in vivo photodynamic therapy (PDT).Phoophorbide A is a lymphatic vasoreactivator with antioxidant, anti-inflammatory, antitumor, and hypoglycemic activities.Phoophorbide A is used in research on diabetes and cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $40 | In Stock | |
| 10 mg | $64 | In Stock | |
| 25 mg | $106 | In Stock | |
| 50 mg | $155 | In Stock |
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Purity:95.03%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Pheophorbide A is a photosensitizer used in in vivo photodynamic therapy (PDT).Phoophorbide A is a lymphatic vasoreactivator with antioxidant, anti-inflammatory, antitumor, and hypoglycemic activities.Phoophorbide A is used in research on diabetes and cancer. |
| In vitro | Pheophorbide A significantly inhibited the growth of Hep3B cells with an IC50 value of 1.5 μM. The intracellular ROS level was increased in the cells treated with Pa-PDT, and the cytotoxic effect could be reversed when ascorbic acid was applied[2]. |
| In vivo | In male immunocompetent C3H mice ( six-week-old, inoculated subcutaneously with AT-84 cells ), Pheophorbide A ( 10 mg / kg intravenous ( i.v. ) or a 30 mg / kg intraperitoneal ( i.p. ) injection ; after 24 h) significantly inhibited tumor growth up to 70 %[1]。 |
| Molecular Weight | 592.68 |
| Formula | C35H36N4O5 |
| Cas No. | 15664-29-6 |
| Smiles | CCc1c(C)\c2=C\c3[nH]c(\C=C4/N=C([C@@H](CCC(O)=O)[C@@H]4C)C4=C5NC(\C=c1/[nH]2)C(C)=C5C(=O)[C@@H]4C(=O)OC)c(C)c3C=C |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | DMSO: 1 mg/mL (1.69 mM), Sonication is recommended. DMF: 1 mg/mL (1.69 mM), Sonication is recommended. DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL Methanol: < 1 mg/mL (Insoluble) | ||||||||||
Solution Preparation Table | |||||||||||
DMSO/DMF
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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