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N,N'-Dimethylthiourea

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Catalog No. T40615Cas No. 534-13-4
Alias DMTU

N,N'-Dimethylthiourea (DMTU) (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical ( OH) and blocks OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including OH scavenging and anti-inflammatory action [1][2] .

N,N'-Dimethylthiourea

N,N'-Dimethylthiourea

🥰Excellent
Catalog No. T40615Alias DMTUCas No. 534-13-4
N,N'-Dimethylthiourea (DMTU) (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical ( OH) and blocks OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including OH scavenging and anti-inflammatory action [1][2] .
Pack SizePriceAvailabilityQuantity
500 mg$41In Stock
1 mL x 10 mM (in DMSO)$44In Stock
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Product Introduction

Bioactivity
Description
N,N'-Dimethylthiourea (DMTU) (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical ( OH) and blocks OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including OH scavenging and anti-inflammatory action [1][2] .
In vivo
N,N'-Dimethylthiourea (DMTU; 1, 2.5, or 5 mmol/kg; orally) administered at 0.5 h before the onset of WIRS reduces the severity of gastric mucosal lesions with attenuation of the changes in the levels of gastric mucosal MPO, pro-inflammatory cytokines, LPO, NOx, nonprotein SH, and vitamin C and gastric adherent mucus found at 3 h after the onset of WIRS in a dose-dependent manner in Male Wistar rats aged 6 weeks [1]. DMTU protects against WIRS-induced gastric mucosal lesions in rats by exerting its antioxidant action including ·OH scavenging and its anti-inflammatory action without affecting the stress response.
AliasDMTU
Chemical Properties
Molecular Weight104.17
FormulaC3H8N2S
Cas No.534-13-4
SmilesCNC(=S)NC
Relative Density.1.055 g/cm3 (Estimated)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (479.98 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM9.5997 mL47.9985 mL95.9969 mL479.9846 mL
5 mM1.9199 mL9.5997 mL19.1994 mL95.9969 mL
10 mM0.9600 mL4.7998 mL9.5997 mL47.9985 mL
20 mM0.4800 mL2.3999 mL4.7998 mL23.9992 mL
50 mM0.1920 mL0.9600 mL1.9199 mL9.5997 mL
100 mM0.0960 mL0.4800 mL0.9600 mL4.7998 mL

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