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9-Hydroxyellipticine hydrochloride is an inhibitor of Topo II and RyR, exhibiting antitumor, antioxidant, and catecholamine-releasing activities. It inhibits Hela S-3 and 293T cells with IC50s of 1.6 μM and 1.2 μM, respectively.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $110 | 35 days |
Description | 9-Hydroxyellipticine hydrochloride is an inhibitor of Topo II and RyR, exhibiting antitumor, antioxidant, and catecholamine-releasing activities. It inhibits Hela S-3 and 293T cells with IC50s of 1.6 μM and 1.2 μM, respectively. |
In vitro | 9-Hydroxyellipticine hydrochloride exhibits concentration-dependent selective inhibition of p53 protein phosphorylation in Lewis lung carcinoma and SW480 (a human colon cancer cell line) within a range of 0.1 to 100 μM [4]. |
In vivo | 9-Hydroxyellipticine (5 or 10 mg/kg, ip) induces chromosome clumping and sister chromatid exchange in murine bone marrow cells [1]. |
Molecular Weight | 298.77 |
Formula | C17H15ClN2O |
Cas No. | 52238-35-4 |
Smiles | Cl.OC1=CC=C2NC3=C(C2=C1)C(=C4C=NC=CC4=C3C)C |
Relative Density. | 1.31g/cm3 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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