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Homobutein
Homobutein (3-O-Methylbutein) is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammatory, antiparasite, and antioxidation activities.
Catalog No. TN4220Cas No. 34000-39-0
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Purity:99.50%
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Homobutein
Catalog No. TN4220Alias 3-O-Methylbutein, 2',4,4'-Trihydroxy-3-methoxychalconeCas No. 34000-39-0
Homobutein (3-O-Methylbutein) is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammatory, antiparasite, and antioxidation activities.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $195 | In Stock | |
| 2 mg | $293 | In Stock | |
| 5 mg | $447 | In Stock | |
| 10 mg | $659 | In Stock | |
| 25 mg | $987 | In Stock | |
| 50 mg | $1,380 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | Homobutein (3-O-Methylbutein) is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammatory, antiparasite, and antioxidation activities. |
| In vitro | Homobutein (1 μg/mL) inhibits the growth of Toxoplasma gondii by 19.48%[1] with IC50s of 15.0 and 16.1 µM for W2 and D6 strains of P. falciparum[2]. Homobutein (20 - 40 μM) inhibits the viability and TNFα-induced NF-κB activity of K562 cells[4]. |
| Alias | 3-O-Methylbutein, 2',4,4'-Trihydroxy-3-methoxychalcone |
| Molecular Weight | 286.28 |
| Formula | C16H14O5 |
| Cas No. | 34000-39-0 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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