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Receptor ProteinsNuclear Receptors
Nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules.Nuclear receptors are specific to animals and are not found in protists, algae, fungi, or plants. There are 47 nuclear receptors in humans.These intracellular receptors work with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. A unique property of nuclear receptors that differentiates them from other classes of receptors is their direct control of genomic DNA. Hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors often occurs in the presence of a ligand. Ligand binding to a nuclear receptor results in a conformational change activating the receptor. The result is up-or down-regulation of gene expression. Nuclear receptors play key roles in both embryonic development and adult homeostasis.
PPAR alpha/PPARA Protein, Human, Recombinant (His)
TMPY-06830
PPAR alpha PPARA Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 31.36 kDa and the accession number is Q07869.
- $600
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PPAR gamma/PPARG Protein, Human, Recombinant (His & GST)
TMPY-02575
Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling events. The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differentiation. Peroxisome proliferator-activated receptor gamma (PPARG) is a transcription factor involved in atherosclerosis and related diseases. Peroxisome proliferator-activated receptor gamma (PPARG) plays an important role in the pathogenesis and maintenance of essential hypertension (EH).The functional single nucleotide polymorphisms in peroxisome proliferator-activated receptor gamma (PPARG) gene were predicted to be correlated with the susceptibility of colorectal cancer (CRC).
- $386
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NR4A1 Protein, Human, Recombinant (His & Myc)
TMPH-01796
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury. NR4A1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 69.5 kDa and the accession number is P22736.
- $284
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NR1I2 Protein, Human, Recombinant (His & Myc & SUMO)
TMPH-01793
NR1I2 Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 69.8 kDa and the accession number is O75469.
- $198
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RORA Protein, Human, Recombinant (His)
TMPH-01791
RORA Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 57.6 kDa and the accession number is P35398.
- $284
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Androgen receptor Protein, Human, Recombinant (His & Myc & SUMO)
TMPH-00932
Androgen receptor Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli.
- $198
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ER alpha Protein, Human, Recombinant (His)
TMPJ-00762
Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but they also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
- $184
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THRB Protein, Human, Recombinant (His)
TMPY-06821
Thyroid hormone receptor beta (THRB), also known as TRbeta and NR1A2, belongs to the nuclear hormone receptor family. Featuring an N-terminal transactivation domain, a central DNA-binding domain, and a hormone ligand-binding domain, THRB isoform 1 2 expression localizes predominately to the liver and pituitary, respectively. THRB regulates the feedback of T3-dependent thyrotropin-stimulating hormone (TSH) transcription in the pituitary by binding to thyroid hormone (TH) response elements present on promoters of TH-responsive genes. Located on chromosome 3p24, THRB gene mutation has been linked to autosomal dominant resistance to TH (RTH), which is characterized by goiter and elevated levels of T3, T4, and TSH. THRB is a known pharmacological target for the treatment of non-alcoholic steatohepatitis (NASH). THRB may be a target for future cancer therapies since its knockdown enhanced the viability of endometrial cancer cells and activated the mTOR-4EBP1 eIF4G pathway.
- $600
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NR2F6 Protein, Human, Recombinant (His & Myc)
TMPH-01794
NR2F6 Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-6xHis-Myc tag. The predicted molecular weight is 47.0 kDa and the accession number is P10588.
- $465
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RORC Protein, Human, Recombinant (His & SUMO)
TMPH-01792
RORC Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 74.2 kDa and the accession number is P51449.
- $198
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THRA Protein, Human, Recombinant (His)
TMPH-02203
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.; Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. THRA Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 58.9 kDa and the accession number is P10827.
- $360
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LXR-alpha Protein, Human, Recombinant (His & Myc)
TMPH-01819
LXR-alpha Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 53.1 kDa and the accession number is Q13133.
- $198
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Vitamin D Receptor/VDR Protein, Human, Recombinant (His)
TMPY-02706
Vitamin D Receptor VDR Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50 kDa and the accession number is P11473.
- $498
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NR4A2 Protein, Human, Recombinant (His)
TMPH-01797
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. NR4A2 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 68.6 kDa and the accession number is P43354.
- $341
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ER beta Protein, Human, Recombinant (E. coli, His)
TMPH-01304
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. ER beta Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 39.8 kDa and the accession number is Q92731.
- $198
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Vitamin D Receptor/VDR Protein, Mouse, Recombinant (His)
TMPY-02987
Vitamin D Receptor VDR Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 49.28 kDa and the accession number is P48281.
- $700
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NR2F6 Protein, Human, Recombinant (His & SUMO)
TMPH-01795
NR2F6 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 59.0 kDa and the accession number is P10588.
- $284
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THRB Protein, Human, Recombinant (His & SUMO)
TMPH-02204
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
- $198
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PPAR gamma Protein, Mouse, Recombinant (His)
TMPH-02827
PPAR gamma Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 63.3 kDa and the accession number is P37238.
- $284
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ER beta Protein, Human, Recombinant (His)
TMPH-01305
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. ER beta Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 61.1 kDa and the accession number is Q92731.
- $231
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Ppard Protein, Human, Recombinant (His)
TMPH-03755
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
- $284
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PPAR gamma Protein, Xenopus laevis, Recombinant (His)
TMPH-03711
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
- $360
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PPAR alpha/PPARA Protein, Mouse, Recombinant (His)
TMPY-06837
PPAR alpha PPARA Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 31.49 kDa and the accession number is P23204.
- $600
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