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Cell Cycle/Checkpoint
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Cell Cycle/CheckpointBMI-1
Polycomb complex protein BMI-1 also known as polycomb group RING finger protein 4 (PCGF4) or RING finger protein 51 (RNF51) is a protein that in humans is encoded by the BMI1 gene (B cell-specific Moloney murine leukemia virus integration site 1). BMI1 is a polycomb ring finger oncogene.
- PRT4165T311031083-55-3PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor.
- $38
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Cited - PTC-209 hydrobromideT61781217022-63-3PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of cancer-initiating cells (CICs).
- $51
SizeQTY - XMD8-92T18431234480-50-2XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).
- $48
SizeQTY - PTC-028T166801782970-28-8PTC-028 selectively suppresses cancer cells whereas normal cells remain unaffected. PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. The depletion of BMI-1 by PTC-028 causes caspase-mediated apoptosis.
- $38
SizeQTY - UnesbulinT125751610964-64-1Unesbulin (PTC596) is an orally active and selective inhibitor of B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1).
- $89
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