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LRRK2
Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin (from the Basque word "dardara" which means trembling) and PARK8 (from early identified association with Parkinson's disease), is a kinase enzyme that in humans is encoded by the LRRK2 gene. LRRK2 is a member of the leucine-rich repeat kinase family. Variants of this gene are associated with an increased risk of Parkinson's disease and also Crohn's disease.
- LRRK2 inhibitor 1T118781802525-61-6In houseLRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM.
- $68
SizeQTY
- LRRK2-IN-7T731762307277-93-4In houseLRRK2-IN-7 is a selective, CNS permeable and potent LRRK2 kinase inhibitor (IC50: 0.9 nM) for the study of Parkinson's disease.
- $239
SizeQTY - CCG-1423T2014285986-88-1CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
- $32
SizeQTY
Cited - LRRK2-IN-1T22461234480-84-2LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.
- $60
SizeQTY Cited - MK-1468T817852769107-89-1MK-1468, a highly selective and brain-penetrant LRRK2 inhibitor, exhibits an IC50 of 0.8 nM and is utilized in the study of Parkinson's disease [1].
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SizeQTY - CZC-25146 hydrochlorideT51391330003-04-7CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
- $50
SizeQTY - CZC-54252 hydrochlorideT392021784253-05-9CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of 1 nM.
- $32
SizeQTY - CZC-25146T30531191911-26-8CZC-25146 (CHEMBL2397014) is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G2019S LRRK2, respectively.
- $30
SizeQTY - GSK2578215AT22401285515-21-0GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
- $45
SizeQTY - GNE-7915T19451351761-44-8GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.
- $39
SizeQTY - LRRK2-IN-10T797462704562-80-9LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2 pS935 and 5.2 nM for G2019S-LRRK2 pS1292. It holds promise for research into Parkinson's disease [1].
- $1,520
SizeQTY - HG-10-102-01T71961351758-81-0HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
- $38
SizeQTY - BIX 02565T54281311367-27-7BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).
- $75
SizeQTY Cited - PFE-360T165121527475-61-1PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).
- $68
SizeQTY - EB-42486T399722390475-81-5EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.
- $125
SizeQTY - IKK 16T6176873225-46-8IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
- $34
SizeQTY - MLi-2T161151627091-47-7MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM), and a radioligand competition binding assay (IC50 = 3.4 nM).
- $60
SizeQTY - GNE-9605T17701536200-31-3GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).
- $32
SizeQTY - GNE0877T60311374828-69-9GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).
- $39
SizeQTY - PF-06447475T20501527473-33-1PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.
- $43
SizeQTY - URMC-099T60571229582-33-5URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
- $52
SizeQTY - JH-II-127T71551700693-08-8JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, respectively),
- $57
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