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CCG-1423

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Purity:99.98%

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COA HNMR HPLC

CCG-1423

Catalog No. T2014Cas No. 285986-88-1

CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.

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Pack Size	Price	Availability
5 mg	$32	In Stock
10 mg	$52	In Stock
25 mg	$97	In Stock
50 mg	$165	In Stock
100 mg	$275	In Stock
200 mg	$428	In Stock
500 mg	$695	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Product Introduction

Bioactivity

Description	CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
Targets&IC50	LRRK2 (WT):1.28 nM, LRRK2 (G2019S):1.85 nM
In vivo	In H9c2 cells, CCG-1423 inhibits MRTF nuclear localization and completely blocks the activity of STARS proximal reporter genes. It also suppresses TGF-β-induced fibrogenesis in human colon myofibroblasts. Under the influence of CCG-1423 and LY294002, mouse embryonic stem cells differentiate into the mesendoderm. In melanoma cells (A375M2 and SK-Mel-147) overexpressing RhoC, CCG-1423 selectively inhibits cell proliferation.
Cell Research	Cells in normal culture medium are plated (2,000 per well) in a 96-well plate coated with laminin. After attachment, the medium is replaced with serum-free medium (0% FBS) with 30 μmol/L LPA with or without 300 nM CCG-1423. Fresh LPA with or without CCG-1423 is added at day 5 to ensure that LPA and compound are present throughout the experiment. On day 8, WST-1 reagent is added to the wells for 1 h and absorbance at 450 nm is read using a Victor plate reader.(Only for Reference)
Alias	CCG1423

Chemical Properties

Molecular Weight	454.75
Formula	C18H13ClF6N2O3
Cas No.	285986-88-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

Ethanol: 4 mg/mL (8.79 mM), Heating is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 83 mg/mL (182.5 mM)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1990 mL	10.9951 mL	21.9901 mL	109.9505 mL
5 mM	0.4398 mL	2.1990 mL	4.3980 mL	21.9901 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2199 mL	1.0995 mL	2.1990 mL	10.9951 mL
20 mM	0.1100 mL	0.5498 mL	1.0995 mL	5.4975 mL
50 mM	0.0440 mL	0.2199 mL	0.4398 mL	2.1990 mL
100 mM	0.0220 mL	0.1100 mL	0.2199 mL	1.0995 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

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