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Azathioprine

Azathioprine
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Purity:100%
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Azathioprine

Catalog No. T1237Cas No. 446-86-6
Azathioprine (BW 57-322), an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation.
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Pack SizePriceAvailabilityQuantity
500 mg$45In Stock
1 g$59In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Product Introduction

Bioactivity
Description
Azathioprine (BW 57-322), an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation.
In vitro
In murine and rat brain allografts, the combination of Azathioprine with Cyclosporin A or Prednisolone significantly enhances survival rates.
In vivo
Azathioprine inhibits Rac1 target genes in primary human CD4+ T lymphocytes, leading to apoptosis via the mitochondrial pathway. In isolated rat hepatocytes, Azathioprine depletes reduced glutathione (GSH), releases lactate dehydrogenase, and decreases cellular viability.
AliasBW 57-322
Chemical Properties
Molecular Weight277.26
FormulaC9H7N7O2S
Cas No.446-86-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 50 mg/mL (180.34 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6067 mL18.0336 mL36.0672 mL180.3361 mL
5 mM0.7213 mL3.6067 mL7.2134 mL36.0672 mL
10 mM0.3607 mL1.8034 mL3.6067 mL18.0336 mL
20 mM0.1803 mL0.9017 mL1.8034 mL9.0168 mL
50 mM0.0721 mL0.3607 mL0.7213 mL3.6067 mL
100 mM0.0361 mL0.1803 mL0.3607 mL1.8034 mL

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