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Azathioprine (BW 57-322), an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 mg | $45 | In Stock | |
1 g | $59 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Azathioprine (BW 57-322), an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation. |
In vitro | In murine and rat brain allografts, the combination of Azathioprine with Cyclosporin A or Prednisolone significantly enhances survival rates. |
In vivo | Azathioprine inhibits Rac1 target genes in primary human CD4+ T lymphocytes, leading to apoptosis via the mitochondrial pathway. In isolated rat hepatocytes, Azathioprine depletes reduced glutathione (GSH), releases lactate dehydrogenase, and decreases cellular viability. |
Alias | BW 57-322 |
Molecular Weight | 277.26 |
Formula | C9H7N7O2S |
Cas No. | 446-86-6 |
Smiles | CN1C=NC(=C1SC1=NC=NC2=C1NC=N2)[N+]([O-])=O |
Relative Density. | 1.9 g/cm3 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (180.34 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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