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Zoledronic Acid
🥰Excellent
Catalog No. T6739Cas No. 118072-93-8
Alias Zometa, Zoledronate, ZOL 446, CGP42446A, CGP 42446
Zoledronic Acid (ZOL 446) is a bisphosphonate. Zoledronic Acid (ZOL 446) is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalcemia of malignancy and can be helpful for treating pain from bone metastases. An annual dose of Zoledronate may also prevent recurring fractures in patients with a previous hip fracture. Zoledronic Acid (ZOL 446) is a single 5 mg infusion for the treatment of Paget's disease of bone. In 2007, the FDA also approved Reclast for the treatment of postmenopausal osteoporosis.
Zoledronic Acid
🥰Excellent
Purity: 99.93%
Catalog No. T6739Alias Zometa, Zoledronate, ZOL 446, CGP42446A, CGP 42446Cas No. 118072-93-8
Zoledronic Acid (ZOL 446) is a bisphosphonate. Zoledronic Acid (ZOL 446) is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalcemia of malignancy and can be helpful for treating pain from bone metastases. An annual dose of Zoledronate may also prevent recurring fractures in patients with a previous hip fracture. Zoledronic Acid (ZOL 446) is a single 5 mg infusion for the treatment of Paget's disease of bone. In 2007, the FDA also approved Reclast for the treatment of postmenopausal osteoporosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $32 | In Stock | |
| 25 mg | $47 | In Stock | |
| 50 mg | $77 | In Stock | |
| 100 mg | $127 | In Stock | |
| 200 mg | $188 | In Stock | |
| 500 mg | $317 | In Stock |
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CitedSelect Batch
Purity:99.93%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | Zoledronic Acid (ZOL 446) is a bisphosphonate. Zoledronic Acid (ZOL 446) is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalcemia of malignancy and can be helpful for treating pain from bone metastases. An annual dose of Zoledronate may also prevent recurring fractures in patients with a previous hip fracture. Zoledronic Acid (ZOL 446) is a single 5 mg infusion for the treatment of Paget's disease of bone. In 2007, the FDA also approved Reclast for the treatment of postmenopausal osteoporosis. |
| In vitro | Zoledronic acid (120 mg/kg, subcutaneously) prevented damage formation, prevented cancellous bone loss and loss of bone mineral density, and reduced osteoclast circumference in 5T2 mM mice, also decreasing paraprotein concentration and tumor load, and reducing angiogenesis. |
| In vivo | Zoledronic acid (120 mg/kg, subcutaneously) prevented damage formation, prevented cancellous bone loss and loss of bone mineral density, and reduced osteoclast circumference in 5T2 mM mice, also decreasing paraprotein concentration and tumor load, and reducing angiogenesis. |
| Alias | Zometa, Zoledronate, ZOL 446, CGP42446A, CGP 42446 |
| Molecular Weight | 272.09 |
| Formula | C5H10N2O7P2 |
| Cas No. | 118072-93-8 |
| Smiles | C(P(=O)(O)O)(P(=O)(O)O)(CN1C=CN=C1)O |
| Relative Density. | 2.13 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 1.6 mg/mL (5.88 mM), Sonication is recommended.  0.1M NAOH: 12.5 mg/mL (45.94 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O/0.1M NAOH
0.1M NAOH
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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