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RMC-6236

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Purity:100%

ee:100%

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RMC-6236

Catalog No. T74698Cas No. 2765081-21-6

RMC-6236 is a RAS(ON)MULTI inhibitor with anticancer activity and is used in the study of advanced malignant solid tumors and colorectal cancer.

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Pack Size	Price	Availability
1 mg	$297	In Stock
5 mg	$786	In Stock
10 mg	$1,180	In Stock
25 mg	$1,980	In Stock
50 mg	$2,890	In Stock
100 mg	$4,130	In Stock

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Product Introduction

Bioactivity

Description	RMC-6236 is a RAS(ON)MULTI inhibitor with anticancer activity and is used in the study of advanced malignant solid tumors and colorectal cancer.
In vitro	METHODS: HPAC and Capan-2 cell lines were treated with RMC-6236 (1, 3, 10, 30nM, 4h), and time and concentration-dependent changes in RAS pathway signaling markers pERK, pAKT and pS6 were observed. RESULTS: Time- and concentration-dependent inhibition of RAS pathway signaling markers pERK, pAKT, and pS6 was observed, with sustained inhibition of pERK and pS6 in Capan-2 cells up to at least 48 h. HPAC cells also exhibited sustained pERK inhibition and time-dependent induction of apoptosis.[2]
In vivo	METHODS: Capan-2 (KRASG12V/WT, PDAC) and NCI-H441 (KRASG12V/WT, NSCLC) xenografted homozygous BALB/c nude mice were treated with RMC-6236 (3, 10, or 25 mg/kg, orally once a day), and blood and tumors were collected at indicated time points. RESULTS: At the 25 mg/kg dose, RMC-6236 was able to maintain more than 80% inhibition of tumor pERK levels within 24 hours of administration; at the 10 mg/kg dose, RMC-6236 caused modest tumor regression in the sensitive model and led to 13% and 29% mean tumor regression in the Capan-2 and NCI-H441 models.[2]
Alias	RMC6236

Chemical Properties

Molecular Weight	811.05
Formula	C44H58N8O5S
Cas No.	2765081-21-6

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 200 mg/mL (246.59 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2330 mL	6.1648 mL	12.3297 mL	61.6485 mL
5 mM	0.2466 mL	1.2330 mL	2.4659 mL	12.3297 mL
10 mM	0.1233 mL	0.6165 mL	1.2330 mL	6.1648 mL
20 mM	0.0616 mL	0.3082 mL	0.6165 mL	3.0824 mL
50 mM	0.0247 mL	0.1233 mL	0.2466 mL	1.2330 mL
100 mM	0.0123 mL	0.0616 mL	0.1233 mL	0.6165 mL

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