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Rhosin hydrochloride
🥰Excellent
Catalog No. T16745Cas No. 1281870-42-5
Rhosin hydrochloride is a specific inhibitor of the RhoA subfamily Rho GTPases and inhibits the RhoA-GEF interaction. Rhosin hydrochloride can significantly induce cell apoptosis without affecting cell cycle progression. [1]
Rhosin hydrochloride
🥰Excellent
Purity: 98.92%
Catalog No. T16745Cas No. 1281870-42-5
Rhosin hydrochloride is a specific inhibitor of the RhoA subfamily Rho GTPases and inhibits the RhoA-GEF interaction. Rhosin hydrochloride can significantly induce cell apoptosis without affecting cell cycle progression. [1]
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $162 | In Stock | |
| 2 mg | $229 | In Stock | |
| 5 mg | $347 | In Stock | |
| 10 mg | $497 | In Stock | |
| 25 mg | $793 | In Stock | |
| 50 mg | $1,080 | In Stock | |
| 100 mg | $1,450 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $382 | In Stock |
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Purity:98.92%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Rhosin hydrochloride is a specific inhibitor of the RhoA subfamily Rho GTPases and inhibits the RhoA-GEF interaction. Rhosin hydrochloride can significantly induce cell apoptosis without affecting cell cycle progression. [1] |
| Targets&IC50 | RhoA:(kd)0.4 uM |
| In vitro | METHODS: To investigate the cytotoxic effects of Rhosin hydrochloride on B16BL6 and 4T1 cells, cell viability was assessed by treating cells with 1-100 μM Rhosin hydrochloride. RESULTS Rhosin hydrochloride at a concentration of 100 μM induced cell death in B16BL6 and 4T1 cells. [1] |
| In vivo | METHODS: B16BL6 cells and 4T1 cells were injected into the tail vein of syngeneic C57BL/6J mice and Balb/c mice. Mice were treated with 10 or 30 mg/kg of Rhosin hydrochloride daily from day 1 to day 14. RESULTS The number of lung metastatic nodules in B16BL6 and 4T1 cells was reduced in a dose-dependent manner after administration of Rhosin hydrochloride, and Rhosin hydrochloride inhibited the metastasis of 4T1-luc tumor cells to the lung region, which could be confirmed by the reduction of photon flux. [1] |
| Molecular Weight | 431.318 |
| Formula | C20H20Cl2N6O |
| Cas No. | 1281870-42-5 |
| Smiles | Cl.N[C@H](Cc1c[nH]c2ccccc12)C(=O)N\N=C\c1ccc2nccnc2c1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (253.25 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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