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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T83705 | BING TFA | Blocker of Inter-membrane Stress Responses of Gram-negative Bacteria | |
BING, a antimicrobial peptide discovered in Japanese medaka fish (O. laptipes), originates from vacuolar protein sorting-associated protein 13D-like (Vps13D). It exhibits efficacy against a range of Gram-negative and Gra... | |||
T8899 | Metipranolol | Adrenergic Receptor | |
Metipranolol is a useful organic compound for research related to life sciences. The catalog number is T8899 and the CAS number is 22664-55-7. | |||
T7845 | BTZO-1 | Apoptosis | |
BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity. | |||
T25049 | Allethrin | BCL , Caspase | |
Allethrin induces oxidative stress, apoptosis and calcium release. Allethrin, a pyrethroid insecticide is a major mosquito repellent agent. | |||
T35648 | 4-Thiouridine | Others | |
4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directl... | |||
T16745 | Rhosin hydrochloride | Apoptosis , Rho , Ras | |
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 o... | |||
T30480 | BiP inducer X | BIX | Apoptosis |
BiP inducer X (BIX) is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines. | |||
T7042 | 1,5-Isoquinolinediol | PARP | |
1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol... | |||
T40130 | Nur77 modulator 1 | Nur77 modulator 1 | Others |
Nur77 modulator 1 is a good Nur77 binder (KD = 3.58 μM). Nur77 modulator 1 up-regulates Nur77 expression, mediates sub-cellular localization of Nur77, induces Nur77-dependent ER stress and autophagy, and results in cell ... | |||
T9110 | Ceapin-A7 | Others | |
Ceapin-A7 is a selective blocker of ATF6α signaling in response to ER stress, with an IC50 of 0.59 μM. Ceapin-A7 can be used to explore both the mechanism of activation of ATF6α and its role in pathological settings. | |||
T8391 | Cesium chloride | CsCl | Potassium Channel |
Cesium chloride (CsCl) is considered to be the most toxic of the alkali chlorides, inhibiting fungal growth. | |||
T5491 | GSK3179106 | c-RET | |
GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM | |||
TP1889 | MCL0020 | MCL 0020 | Melanocortin Receptor |
MCL0020 is a potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no e... | |||
T6854 | GSK621 | Apoptosis , AMPK , Autophagy | |
GSK621 is a specific and potent AMPK activator. | |||
T21902 | ML351 | Lipoxygenase | |
ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM). | |||
T4400 | DIM-C-pPhOH | CDIM8 | Apoptosis , Others |
DIM-C-pPhOH (CDIM8) is a nur77 (NR4A1) antagonist,inhibits TGF-β induced cell migration of breast cancer cell lines,promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines,mimi... | |||
T7127 | DC260126 | Apoptosis , GPR | |
DC260126 is a small-molecule antagonist of FFA1 (GPR40) | |||
T5345 | V-9302 | Others | |
V-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM). | |||
T5486 | RU.521 | RU320521 | DNA , cGAS |
RU.521 (RU3205217) is a potent dsDNA inhibitor (IC50 : 700 nM), inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS. | |||
T6800 | CCF642 | AC1LYELL | Others |
CCF642 (AC1LYELL) is a novel PDI-inhibiting compound with antimyeloma activity. | |||
T1997 | JNJ-31020028 | JNJ 31020028 | Neuropeptide Y Receptor |
JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22, rat); it exhibits >100-fold selectivity for Y2 versus human Y1/Y4/Y5 receptors. | |||
T9149 | 2BAct | 2B-Act,2B Act | PERK |
2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response | |||
T16481 | PF-04995274 | 5-HT Receptor | |
PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. PF-04995274 has a... | |||
T0159 | Pranoprofen | Pyranoprofen | Apoptosis , COX , PGE Synthase , Prostaglandin Receptor |
Pranoprofen (Pyranoprofen) (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology. | |||
T8901 | YUM70 | Apoptosis , GPR , HSP | |
YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein). It induces endoplasmic reticulum (ER) stress-mediate... | |||
T12579 | RAMB4 | PTP1B-IN-9 | Proteasome |
RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity. | |||
T0084 | Moclobemide | Ro111163 | MAO , Monoamine Oxidase |
Moclobemide (Ro111163) is a reversible inhibitor of monoamine oxidase type A; (RIMA); (see MONOAMINE OXIDASE INHIBITORS) that has antidepressive properties. | |||
T21995 | XAP044 | GluR | |
XAP044 is a mGlu7-selective antagonist which inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice with a half-maximal blockade at 88 nm[1]. | |||
T6708 | Tolcapone | Tasmar,Ro 40-7592 | Apoptosis , Beta Amyloid , Transferase |
Tolcapone (Ro 40-7592) is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa and carbidopa. | |||
T5827 | BI-6C9 | Apoptosis , Others , Mitochondrial Metabolism | |
BI-6C9 is an inhibitor of tBid (Kd = 20 µM).BI-6c9 prevented MOMP and mitochondrial fission, and protected the cells from cell death. | |||
T2710 | TCS 1102 | OX Receptor | |
TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors). | |||
T1862 | PR-619 | PR 619,2,6-Diamino-3,5-dithiocyanopyridine | Apoptosis , DUB , Autophagy |
PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs). | |||
T21935L | AMN082 free base | AMN082 | GluR |
AMN082 free base is a metabotropic glutamate receptor 7 allosteric agonist. | |||
T3722 | MK-1064 | Urokinase inhibitor 1,MK 1064 | OX Receptor |
MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA). | |||
T7511 | Cyclo(his-pro) | NF-κB , Endogenous Metabolite | |
Cyclo(his-pro) is an endogenous cyclic dipeptide that exerts oxidative damage protection by selectively activating the transcription factor Nrf2 signalling pathway. | |||
T23550 | YM-750 | YM 750 | Acyltransferase |
YM-750 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50=0.18 μM). ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A. | |||
T9174 | Icerguastat | Sephin 1,lcerguastat,IFB-088 | Phosphatase |
Icerguastat (IFB-088) is a selective inhibitor of holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo. | |||
T7318 | Elimusertib | BAY-1895344 | ATM/ATR |
Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the target... | |||
TP1929L1 | Saralasin acetate(34273-10-4 free base) | RAAS | |
Saralasin acetate is a Non-selective angiotensin II antagonist. | |||
T2371 | Emapunil | AC-5216,XBD-173 | Others |
Emapunil (XBD-173) is an anxiolytic drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO. | |||
T5371 | L-BUTHIONINE-(S,R)-SULFOXIMINE | L-Butionine sulfoximine | Others , Ferroptosis |
L-Buthionine-(S,R)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM) that induces oxidative stress in cells by depleting GSH. | |||
T23146 | PHA 568487 free base | PHA 568487 | AChR |
The quinuclidine PHA 568487 free base is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated lia... | |||
T6170 | Elesclomol | STA-4783 | Apoptosis , HSP , Reactive Oxygen Species |
Elesclomol (STA-4783) is an oxidative stress inducer and a highly lipophilic copper ion carrier. Elesclomol induces apoptosis in tumor cells and is used in copper death related studies. Elesclomol also inhibits FDX1-medi... | |||
T9516 | Binodenoson | WRC 0470,MRE-0470,2-(cyclohexylmethylidenehydrazino)adenos | Adenosine Receptor |
Binodenoson (WRC 0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stres... | |||
T7739 | L-Leucyl-L-Leucine methyl ester hydrochloride | Leu-Leu-ome hydrochloride | Others , Endogenous Metabolite |
L-Leucyl-L-Leucine methyl ester hydrochloride (Leu-Leu-ome hydrochloride) is a lysosomal condensation product that cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes. | |||
T1909 | L-701324 | L701324 | NMDAR , iGluR |
L-701324 is an NMDA receptor with high affinity and selectivity for the glycine site, used as an orally active and long-acting anticonvulsant. | |||
T1487 | Fluvastatin sodium | XU 62320 sodium,XU-62-320,Fluvastatin sodium salt | Ferroptosis , HMG-CoA Reductase , Autophagy |
Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent. | |||
T5882 | 3-Bromopyruvic acid | Hexokinase II Inhibitor II, 3-BP,Bromopyruvic acid | Apoptosis , Hexokinase , Autophagy |
3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinu... | |||
T0787 | Butylhydroxyanisole | BHA,E320,Butylated hydroxyanisole | Antioxidant , Ferroptosis , Reactive Oxygen Species |
Butylhydroxyanisole (BHA) is an antioxidant consisting of a mixture of two isomeric organic compounds, 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydroxyanisole. | |||
T14364 | AZ-Dyrk1B-33 | 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine | DYRK |
AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2738 | Dehydroandrographolide | NOS , Influenza Virus | |
Dehydroandrographolide is a natural compound extracted from herbal medicine Andrographis paniculata (Burm f) Nees. | |||
TC0039 | Vasicinone | Others | |
Vasicinone may act as a hepatoprotective agent. (±)-Vasicinone has significant antitussive, expectorant, and bronchodilating activities, which can be used to treat respiratory disease.(S)-Vasicinone exhibits antiprolifer... | |||
T5S1099 | Liensinine | Apoptosis , Mitophagy , Others , Autophagy | |
1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias. | |||
T7982 | 3,6-Dihydroxyflavone | Others | |
3,6-Dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway. | |||
T5783 | Rosamultin | Antioxidant , HIV Protease | |
Rosamultin has antioxidant, antiinflammatory/antinociceptive properties,and has anti-human immunodeficiency virus (HIV) activity. | |||
T8678 | Naphthazarin | 5,8-Dihydroxy-1,4-naphthoquinone,DHNQ | Apoptosis |
Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone) is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, inter... | |||
T3394 | Timosaponin BII | Prototimosaponin A III | Beta Amyloid , Others , BACE |
Timosaponin BII (Prototimosaponin A III) has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-regulation of BACE1 and reduced the... | |||
T41358 | 2-Hydroxybenzylamine | Others | |
2-Hydroxybenzylamine, a potent small molecule scavenger of IsoLGs, sequesters the reactive species as inert adducts. 2-Hydroxybenzylamine may be used to decrease early recurrence of atrial fibrillation and other atrial a... | |||
TQ0302 | Thapsigargin | Apoptosis , SARS-CoV , Calcium Channel | |
Thapsigargin is a microsomal Ca2+-ATPase inhibitor and Endoplasmic Reticulum stress-inducing agent. | |||
TN2244 | Sulfuretin | NF-κB , Autophagy | |
Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 thr... | |||
TN1926 | Methyl caffeate | Methyl caffeate acid | Others , Antibacterial |
Methyl caffeate (Methyl caffeate acid) acid | |||
T2800 | L-Theanine | Apoptosis , Others | |
L-Theanine is a relaxing and nondietary amino acid found pretty much exclusively in teas from Camellia sinensis and is known to promote relaxation without sedation. | |||
T10148 | 4-Hydroxynonenal | 4-HNE | Dehydrogenase , Endogenous Metabolite |
4-Hydroxynonenal (4-HNE) (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). | |||
TJO2742 | DL-Methionine | methionine,Acimetion,Racemethionine | Parasite |
DL-Methionine (Acimetion) is an amino acid. Amino acids are the building blocks that our bodies use to make proteins. DL-Methionine is found in meat, fish, and dairy products. It plays an important role in the many funct... | |||
T2230 | Paeoniflorin | Peoniflorin | HSP , COX |
Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall. | |||
T15133 | Dinoprost | Prostaglandin F2a,PGF2α | Endogenous Metabolite |
Dinoprost (Prostaglandin F2a) is a naturally occurring prostaglandin. It is used in medicine to induce labor and as an abortifacient. | |||
T0626 | Uric Acid | 2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate | Reactive Oxygen Species , Endogenous Metabolite , Phosphorylase |
Uric Acid (Lithic acid) is an oxidation product of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE ... | |||
T2198 | Arecoline hydrobromide | Arecoline HBr,Arecoline bromide | AChR |
Arecoline hydrobromide (Arecoline HBr) is a muscarinic acetylcholine receptor agonist. | |||
TQ0211 | Brusatol | (+)-Brusatol,NSC 172924 | Others , Ferroptosis , Nrf2 |
Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2. | |||
T3S1068 | Oxyresveratrol | trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,Tetrahydroxystilbene | Tyrosinase , Autophagy , HSV |
1. Oxyresveratro can inhibit tyrosinase activity. 2. Oxyresveratro is useful to trauma models, as toxicity to glia could be beneficial by inhibiting reactive gliosis. 3. Oxyresveratrol (trans-Oxyresveratrol) has antioxid... | |||
T3982 | Vulpinic Acid | Vulpic acid,Pulvinic acid methyl ester | Others |
Vulpinic Acid (Pulvinic acid methyl ester) is a lichen metabolite with anti-inflammatory, antibacteria, properties, plant growth inhibitor. | |||
T2532 | Tauroursodeoxycholate | Taurolite,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA | Apoptosis , ERK , P450 , Caspase , Endogenous Metabolite |
Tauroursodeoxycholate (UR 906), also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursode... | |||
T8193 | α-Thujone | Thujone,ALPHA-(-)-THUJONE | Apoptosis , Reactive Oxygen Species , GABA Receptor , AChR , Parasite , Autophagy |
α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM. | |||
T3324 | Lycorine | Galanthidine,Narcissine,Amarylline,Belamarine,Licorine | Apoptosis , Virus Protease , Antibacterial , AChR , Fatty Acid Synthase |
Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive. | |||
T1205 | Chloramphenicol | Chlornitromycin,Levomycetin,Chloromycetin | ribosome , HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic |
Chloramphenicol (Chloromycetin), a broad-spectrum antibiotic, blocks bacterial protein synthesis. | |||
T2870 | Matrine | Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine | Mitophagy , Ferroptosis , Opioid Receptor , Autophagy |
Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist. | |||
T37710 | 5-Hydroxyoxindole | Reactive Oxygen Species | |
5-Hydroxyoxindole has been identified as a urinary metabolite of indole, which is produced from tryptophane via the tryptophanase activity of gut bacteria [1]. 5-Hydroxyoxindole has lipid peroxidation inhibition activit... | |||
T0200 | α-Lipoic Acid | Thioctic acid,DL-α-Lipoic acid,(±)-α-Lipoic acid | Apoptosis , NF-κB , HIV Protease , Mitochondrial Metabolism , Endogenous Metabolite |
α-Lipoic Acid (DL-α-Lipoic acid) an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme ... | |||
T3388 | Calycosin-7-O-β-D-glucoside | calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside | MMP , Reactive Oxygen Species |
Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) possesses a protective effect on rat hepatocytes, an inhibitory effect on COX-2 activity. Calycosin 7-O-β-D-glucoside has antimicrobial activity. Calycos... | |||
TN6339 | (R)-5-Hydroxy-1,7-diphenylheptan-3-one | (5R)-Dihydroyashabushiketol | Others |
(R)-5-Hydroxy-1,7-diphenylheptan-3-one ((5R)-Dihydroyashabushiketol) is extracted from the rhizomes of Alpinia officinarum, a Chinese medicinal herb. (R)-5-Hydroxy-1,7-diphenylheptan-3-one inhibits melanogenesis in theop... | |||
TN1909 | Malvidin-3-glucoside chloride | Malvidin-3-O-glucoside chloride,Oenin chloride | Others |
Malvidin-3-glucoside chloride (Oenin chloride) has antioxidant activity, alone is not oxidized in the presence of grape polyphenol oxidase. Malvidin-3-O-glucoside chloride's color stabilization at a higher pH can be expl... | |||
T20597 | Alginic acid | Protanal LF,Snow acid algin G,Kelacid,Sazzio,Norgine | Apoptosis , Autophagy , Histamine Receptor |
Alginic acid (Snow acid algin G) is a natural polysaccharide extracted from brown seaweeds with anti-anaphylactic and anti-inflammatory activities. Alginic acid inhibits histamine release and can be used in the food indu... | |||
T6S0117 | Avicularin | Fenicularin | ERK |
1. Avicularin (Fenicularin) exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW 264.7 macrophage cells. 2. Avicularin inhibits the accumulation of the intracellular ... | |||
T3S0488 | Syringaresinol diglucoside | Syringaresinol-di-O-glucoside | Others |
Syringaresinol diglucoside (Syringaresinol-di-O-glucoside) protects the animals from the stress-induced decreases in sex behaviours and in rectal temperature, the stress-induced failure of retrieval of memory, and the st... | |||
T0632 | 3,4,5-Trimethoxybenzoic acid | Gallic acid trimethyl ether,Eudesmic acid,Trimethylgallic Acid,Benzoic acid,Tri-O-methylgallic acid | Antioxidant |
3,4,5-Trimethoxybenzoic acid (Gallic acid trimethyl ether) are potent antioxidants and inhibitor of cytokine production. It can ameliorate chronic stress-induced various behavioral and biochemical alterations in mice. It... | |||
T8704 | 4-hydroxyphenyl acetate | Nrf2 | |
4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer | |||
T5S1261 | Methylophiopogonanone B | Ras | |
1. Methylophiopogonanone B (MOPB) induces cell morphological change and Rho activation via melanocyte dendrite retraction and stress fiber formation. | |||
T6S1768 | Narcissin | Isorhamnetin 3-Rutinoside,Narcissoside | Antioxidant |
Narcissin (Isorhamnetin 3-Rutinoside), with synergism of B.flavum flavonoid and rutin, could be responsible for stronger protection against mitochondrial induced oxidative stress. | |||
T2805 | Chlorogenic Acid | NSC-407296,3-O-Caffeoylquinic acid,Heriguard | Others , Influenza Virus , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , Antibacterial |
Chlorogenic Acid (NSC-407296) is a naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats. | |||
T0335 | Sodium salicylate | Salicylic acid sodium salt,2-Hydroxybenzoic acid sodium salt | Apoptosis , NF-κB , COX , S6 Kinase , Autophagy |
Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress. | |||
T4868 | Gamma-Linolenic acid | gamolenic acid,γ-Linolenic acid | Endogenous Metabolite |
gamma-Linolenic acid (gamolenic acid), is an unsaturated fatty acid synthesized from linoleic acid (LA) by the enzyme delta-6-desaturase. Research on hepatocellular cell lines has shown γ-Linolenic Acid to have induced r... | |||
T19418 | Methionine sulfoxide | Endogenous Metabolite | |
Methionine sulfoxide can be regarded as a biomarker of oxidative stress in vivo. Methionine sulfoxide is an oxidation product of methionine with reactive oxygen species. | |||
TN1067 | Galloylpaeoniflorin | 6'-O-Galloyl paeoniflorin | NF-κB , Androgen Receptor , ROS |
Galloylpaeoniflorin (6'-O-Galloyl paeoniflorin) may be developed as a cytoprotector against ROS-mediated oxidative stress. Galloylpaeoniflorin is also an inhibtior of NF-κB and DNA cleavage. | |||
T5665 | Geraniol | Others , Endogenous Metabolite , Antifungal | |
geraniol provides a potent protective effect against cardiac dysfunction induced by diabetes. This ameliorative effect could be attributed to its suppression of oxidative stress. | |||
T3405 | [6]-Gingerol | 6-Gingerol,gingerol,(S)-(+)-[6]Gingerol | Apoptosis , AMPK |
[6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bowel, among other tissues. | |||
TN6778 | Umbelliprenin | 7-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl]oxy]-2H-1-benzopyran-2-oneUmbelliprenin | IL Receptor |
Umbelliprenin (7-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl]oxy]-2H-1-benzopyran-2-oneUmbelliprenin) alleviated neuropathic pain, and decreased serum IL-6 levels and oxidative stress. | |||
T6S1966 | Curculigoside | Curculigoside A | Antioxidant , NF-κB , JAK , STAT |
1. Curculigoside (Curculigoside A) can prevent bone loss , improve osteogenesis and inhibit osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic differentiation for treating bone disord... | |||
TN4619 | Tridecane | n-Tridecane | Others |
n-Tridecane (n-Tridecane) is both a stress compound released by the brown marmorated stink bugs and an volatile oil component isolated from essential oil of Piper aduncum L. Tridecane. | |||
T3671 | Vitexin-2"-O-rhamnoside | 2''-O-Rhamnosylvitexin,Vitexin-2-O-rhaMnoside,Vitexin-2''-O-rhamnoside,Apigenin-8-C-glucoside | Others |
Vitexin-2"-O-rhamnoside (Apigenin-8-C-glucoside) is a compound contributes to the protection against H O -mediated oxidative stress damage. | |||
T8255 | (±)-Catechin | (±)-Catechin hydrate | ROS , COX |
(±)-Catechin ((±)-Catechin hydrate) hydrate is a natural product,has antioxidant activity and is effective in reducing oxidative stress. | |||
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Cat No. | Product Name | Species | Expression System |
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TMPY-04460 | OXSR1 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
Oxidative stress-responsive 1 protein (OXSR1), also known as Serine/threonine-protein kinase OSR1, is a member of the Ser/Thr protein kinase family of proteins. OXSR1 regulates downstream kinases in response to environme... | |||
TMPJ-00433 | VSIR Protein, Cynomolgus, Recombinant (His) | Cynomolgus | Human Cells |
platelet receptor Gi24 is a single-pass type I membrane protein, and located at the cell surface. The protein can be cleaved by MMP14, and stimulate MMP14-mediated MMP2 activation. It is participated in the BMP signaling... | |||
TMPJ-01372 | Cornulin Protein, Human, Recombinant (His) | Human | E. coli |
Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-ter... | |||
TMPJ-01382 | HSPB8 Protein, Human, Recombinant (His) | Human | E. coli |
Heat shock protein beta-8 (HSPB8) belongs to the small heat shock protein (HSP20) family. This protein can be inducted by 17-beta-estradiol, and is predominantly expressed in skeletal muscle and heat, mainly located in t... | |||
TMPY-04753 | IRE1 Protein, Human, Recombinant (aa 465-977) | Human | Baculovirus-Insect Cells |
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ... | |||
TMPY-04413 | IRE1 Protein, Human, Recombinant (aa 465-977, His & GST) | Human | Baculovirus-Insect Cells |
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ... | |||
TMPY-02443 | HSP70 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
HSPA1A is a member of the Hsp70 protein family. The 70 kilodalton heat shock proteins (Hsp70s) are a family of ubiquitously expressed heat shock proteins. HSP are abundant and conserved proteins present in all cells. Upo... | |||
TMPY-01403 | VNN1 Protein, Human, Recombinant (His) | Human | HEK293 |
Pantetheinase, also known as Pantetheine hydrolase, Vascular non-inflammatory molecule 1, Vanin-1, and VNN1, is a cell membrane protein which belongs to the CN hydrolase family and BTD/VNN subfamily. Vanin-1 contains one... | |||
TMPY-04580 | IL-1RAP/IL-1RAcP Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane ... | |||
TMPY-05593 | IL-1RAP/IL-1RAcP Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane ... | |||
TMPY-05840 | IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane ... | |||
TMPY-03256 | NKG2D/CD314 Protein, Human, Recombinant (aa 78-216, His) | Human | Baculovirus-Insect Cells |
KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular protei... | |||
TMPY-03376 | NKG2D/CD314 Protein, Rhesus, Recombinant (aa 78-216, His) | Rhesus | Baculovirus-Insect Cells |
KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular protei... | |||
TMPY-00467 | NKG2D/CD314 Protein, Human, Recombinant (hFc) | Human | CHO |
KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular protei... | |||
TMPY-05414 | NKG2D/CD314 Protein, Mouse, Recombinant (hFc) | Mouse | Baculovirus-Insect Cells |
KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular protei... | |||
TMPY-00541 | LON PROTEASE Protein, E. coli, Recombinant (His) | E. coli | E. coli |
Lon protease, an ATP-dependent mitochondrial protease, is important in mitochondrial protein maintenance. Lon protease is a multifunctional enzyme, and its functions include the degradation of damaged proteins and natura... | |||
TMPY-04329 | Vimentin Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Vimentin is a type III intermediate filament (IF) protein found in various non-epithelial cells, especially mesenchymal cells. A vimentin monomer, has a central α-helical domain and carboxyl (tail) domains. Two monomers ... | |||
TMPY-01066 | MICB Protein, Human, Recombinant (His) | Human | HEK293 |
MHC class I polypeptide-related sequence B, also known as MICB, is a heavily glycosylated protein serving as a ligand for the type II receptor NKG2D. MICB shares 85% amino acid identity with MICA, a closely related prote... | |||
TMPY-04572 | MKK4 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is... | |||
TMPY-02078 | HtrA2/Omi Protein, Human, Recombinant (His) | Human | E. coli |
Serine protease HTRA2, also known as high-temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI and HTRA2, is a single-pass membrane protein that belongs to the ... | |||
TMPY-01289 | DDR1 Protein, Human, Recombinant (His) | Human | HEK293 |
Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracell... | |||
TMPY-00463 | ENPP2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogen... | |||
TMPY-02778 | ENPP2 Protein, Human, Recombinant (His) | Human | HEK293 |
ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogen... | |||
TMPY-03523 | ANGPTL4 Protein, Human, Recombinant (His) | Human | HEK293 |
ANGPTL4, also known as ANGPTL2, is a protein with hypoxia-induced expression in endothelial cells. It contains 1 fibrinogen C-terminal domain and is expressed at high levels in the placenta, heart, liver, muscle, pancrea... | |||
TMPY-01478 | HSP90 alpha Protein, Human, Recombinant | Human | E. coli |
Heat shock protein 90 (90 kDa heat-shock protein, HSP90) is a molecular chaperone involved in the trafficking of proteins in the cell. It is a remarkably versatile protein involved in the stress response and normal homoe... | |||
TMPY-05476 | MICA Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
MHC class I chain-related molecules A (MICA) is one of the genes in the HLA class I region, which belongs to the MHC class I family. It is the member of the non-classical class I family that displays the greatest degree ... | |||
TMPY-02053 | MICA Protein, Human, Recombinant (His), MICA*018 | Human | HEK293 |
MHC class I chain-related molecules A (MICA) is one of the genes in the HLA class I region, which belongs to the MHC class I family. It is the member of the non-classical class I family that displays the greatest degree ... | |||
TMPY-01691 | Clusterin Protein, Human, Recombinant (CLU34, His) | Human | HEK293 |
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot... | |||
TMPY-00991 | LIFR Protein, Human, Recombinant (His) | Human | HEK293 |
LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus aff... | |||
TMPY-05493 | LIFR Protein, Human, Recombinant (hFc) | Human | HEK293 |
LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus aff... | |||
TMPY-01694 | Clusterin Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot... | |||
TMPY-04396 | C-ABL/ABL1 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy... | |||
TMPY-02005 | Mucin-1/MUC1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Mucin 1, cell surface-associated (MUC1) or polymorphic epithelial mucin (PEM) is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming pr... | |||
TMPY-04340 | Mucin-1/MUC1 Protein, Human, Recombinant | Human | HEK293 |
Mucin 1, cell surface-associated (MUC1) or polymorphic epithelial mucin (PEM) is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming pr... | |||
TMPH-01001 | BCL10 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essenti... | |||
TMPH-02327 | ZW10 interactor/ZWINT Protein, Human, Recombinant (GST) | Human | E. coli |
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Promotes assembly of stress granules (SGs), when overexpres... | |||
TMPY-02648 | PACAP receptor/ADCYAP1R1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Pituitary adenylate cyclase activating polypeptide (PACAP, Adcyap1) activation of PAC1 receptors ( Adcyap1r1) significantly increases excitability of guinea pig cardiac neurons. This modulation of excitability is mediate... | |||
TMPY-02072 | HSF1 Protein, Human, Recombinant (His) | Human | E. coli |
Heat shock factor protein 1, also known as heat shock transcription factor 1, HSF1, and HSTF1, is a cytoplasm and nucleus protein that belongs to the HSF family. HSF1 is the major transcription factor of HSPs (heat shock... | |||
TMPY-04260 | P38 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
MAPK14 contains 1 protein kinase domain and belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as prol... | |||
TMPH-01498 | HJURP Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA... | |||
TMPH-00670 | MscL Protein, E. coli O157:H7, Recombinant (B2M & His) | E. coli | E. coli |
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and... | |||
TMPH-03108 | GPX5 Protein, Pig, Recombinant (E. coli, His & Myc) | Sus scrofa (Pig) | E. coli |
Glutathione peroxidase-like protein that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress. Plays an important role in the oxidative stress-induced response in the pres... | |||
TMPH-01665 | TIMP3 Protein, Human, Recombinant (His) | Human | E. coli |
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens ... | |||
TMPH-02256 | Trypsin-3 Protein, Human, Recombinant (His) | Human | E. coli |
Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S... | |||
TMPH-02063 | SLFN12 Protein, Human, Recombinant (His) | Human | in vitro E. coli expression system |
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. | |||
TMPH-03443 | GPX2 Protein, S. cerevisiae, Recombinant (His & Myc) | Saccharomyces cerevisiae | E. coli |
Glutathione peroxidase-like protein that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress. Plays an important role in the oxidative stress-induced response in the pres... | |||
TMPH-00587 | Beta-lactamase TEM Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli |
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions. | |||
TMPH-00671 | Major curlin subunit Protein, E. coli O157:H7, Recombinant (His) | E. coli | Yeast |
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and... | |||
TMPH-02407 | Peroxidase Protein, Lentinula edodes, Recombinant (His & Myc) | Lentinula edodes | E. coli |
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks. | |||
TMPY-02043 | PARK7/DJ-1 Protein, Human, Recombinant (His) | Human | E. coli |
Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress.... | |||
------------------------ More ------------------------ |
Cat No. | Product Name | ||
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L9700 | Endoplasmic Reticulum Stress Compound Library | 193 compounds | |
A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS); | |||
L2910 | Antioxidant Compound Library | 1330 compounds | |
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species (ROS) and a biological system's ability to readily detoxify the reactive intermediates or repair the resulting damage. ... | |||
L3200 | Autophagy Compound Library | 1248 compounds | |
A unique collection of 1248 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) and high content screening (HCS) for new drugs; | |||
L5300 | Mitochondria-Targeted Compound Library | 830 compounds | |
A unique collection of 830 promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for research in mitochondrial medicine; | |||
L1400 | MAPK Inhibitor Library | 367 compounds | |
A unique collection of 367 compounds targeting MAPK signaling for drug discovery in MAPK related diseases; | |||
L8710 | Cuproptosis Compound Library | 411 compounds | |
TargetMol’s Cuproptosis Compound Library is a collection of 411 compounds related to copper-dependent death that can be used to study its mechanism and related diseases. | |||
L1310 | Cytoskeletal Signaling Pathway Compound Library | 773 compounds | |
A unique collection of 773 cytoskeleton-related compounds, can be used for HTS and HCS; | |||
L9840 | Anti-Alzheimer's Disease Compound Library | 1040 compounds | |
A unique collection of 1040 compounds with anti-AD activities or acting on main drug targets of AD can be used for HTS and HCS. | |||
L2550 | Glutamine Metabolism Compound Library | 580 compounds | |
A unique collection of 580 glutamine metabolism related compounds can be used for high throughput screening (HTS) and high content screening (HCS), and also is an effective tool for research in glutamine metabolism and ... |