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Monomethyl lithospermate
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Catalog No. TN3323Cas No. 933054-33-2
Alias Lithospermic acid monomethyl ester
Monomethyl lithospermate (Lithospermic acid monomethyl ester) has potential antiviral activity, alleviating ischemic stroke injury in vivo in middle cerebral artery occlusion mice by activating PI5K/Akt signaling and protecting oxygen-glucose deprivation/reoxygenation-induced SHSY-3Y cells in vitro. Monomethyl lithospermate could improve the viability of SHSY-5Y cells, inhibit mitochondrial membrane potential (MMOP) collapse, and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of middle artery occlusion (MCAO) rats and improved nerve damage in ischemic stroke (IS) rats.
Monomethyl lithospermate
😃Good
Catalog No. TN3323Alias Lithospermic acid monomethyl esterCas No. 933054-33-2
Monomethyl lithospermate (Lithospermic acid monomethyl ester) has potential antiviral activity, alleviating ischemic stroke injury in vivo in middle cerebral artery occlusion mice by activating PI5K/Akt signaling and protecting oxygen-glucose deprivation/reoxygenation-induced SHSY-3Y cells in vitro. Monomethyl lithospermate could improve the viability of SHSY-5Y cells, inhibit mitochondrial membrane potential (MMOP) collapse, and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of middle artery occlusion (MCAO) rats and improved nerve damage in ischemic stroke (IS) rats.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $358 | Backorder | |
| 5 mg | $879 | Backorder |
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Product Introduction
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Chemical Properties
| Description | Monomethyl lithospermate (Lithospermic acid monomethyl ester) has potential antiviral activity, alleviating ischemic stroke injury in vivo in middle cerebral artery occlusion mice by activating PI5K/Akt signaling and protecting oxygen-glucose deprivation/reoxygenation-induced SHSY-3Y cells in vitro. Monomethyl lithospermate could improve the viability of SHSY-5Y cells, inhibit mitochondrial membrane potential (MMOP) collapse, and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of middle artery occlusion (MCAO) rats and improved nerve damage in ischemic stroke (IS) rats. |
| In vitro | Monomethyl lithospermate (5, 10 and 20 μM; 12 h) increases cell viability of SHSY-5Y cells treated with oxygen-glucose deprivation and reperfusion (OGD/R).[1] Monomethyl lithospermate (20 μM; 12 h) reduces cell damage, mitochondrial membrane potential loss, and apoptosis in SHSY-5Y cells after hypoxia, glucose deprivation/reoxygenation.[1] Monomethyl lithospermate (5, 10 and 20 μM; 12 h) reduces ROS and intracellular oxidative stress in SHSY-5Y cells.[1] Monomethyl lithospermate (20 μM; 12 h) activates PI3K/AKT in SHSY-5Y cells.[1] |
| In vivo | Monomethyl lithospermate (72.4 μM/kg; oral; once daily for 14 days) improves neurological function, reduces cerebral infarct size, oxidative stress levels, and neuronal apoptosis in rats with ischemia-reperfusion (IR) 24 h after middle artery occlusion (MCAO) by activating PI3K/AKT.[1] |
| Alias | Lithospermic acid monomethyl ester |
| Molecular Weight | 552.48 |
| Formula | C28H24O12 |
| Cas No. | 933054-33-2 |
| Smiles | C(OC)(=O)[C@H]1C=2C(O[C@@H]1C3=CC(O)=C(O)C=C3)=C(O)C=CC2/C=C/C(O[C@H](CC4=CC(O)=C(O)C=C4)C(O)=O)=O |
| Relative Density. | 1.564 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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