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Miclxin
🥰Excellent
Catalog No. T73415Cas No. 2494198-61-5
Alias DS37262926
Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potent inhibitor of mutant β-catenin, which is involved in the Wnt signaling pathway.Miclxin induces β-catenin-dependent apoptosis, leading to mitochondrial damage and loss of mitochondrial membrane. Miclxin has anti-tumor activity and kills tumors by targeting MIC60.
Miclxin
🥰Excellent
Purity: 100%
Catalog No. T73415Alias DS37262926Cas No. 2494198-61-5
Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potent inhibitor of mutant β-catenin, which is involved in the Wnt signaling pathway.Miclxin induces β-catenin-dependent apoptosis, leading to mitochondrial damage and loss of mitochondrial membrane. Miclxin has anti-tumor activity and kills tumors by targeting MIC60.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $96 | In Stock | |
| 5 mg | $239 | In Stock | |
| 10 mg | $337 | In Stock | |
| 25 mg | $569 | In Stock | |
| 50 mg | $792 | In Stock | |
| 100 mg | $1,090 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $263 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potent inhibitor of mutant β-catenin, which is involved in the Wnt signaling pathway.Miclxin induces β-catenin-dependent apoptosis, leading to mitochondrial damage and loss of mitochondrial membrane. Miclxin has anti-tumor activity and kills tumors by targeting MIC60. |
| In vitro | Miclxin (0-15 μM; 48 h) inhibits growth in both β-catenin mutant HCT116 cells and isogenic HCT116 cells (CTNNB1 Δ45/-), and at (10 μM; 24 h) induces apoptosis in HCT116 cells.[1] |
| Alias | DS37262926 |
| Molecular Weight | 441.52 |
| Formula | C26H27N5O2 |
| Cas No. | 2494198-61-5 |
| Smiles | N(CC1=CC(OC)=CC=C1)C=2C3=C(N=C(N2)N4CC(CC4)C=5C=CC=NC5)C=C(OC)C=C3 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (113.25 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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