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EMT inhibitor-1
Catalog No. T11190Cas No. 1638526-21-2
EMT inhibitor-1 is a compound that inhibits Hippo and Wnt signaling pathways, as well as TGF- macrophages (TGF-), exhibiting antitumor activity.
EMT inhibitor-1
Catalog No. T11190Cas No. 1638526-21-2
EMT inhibitor-1 is a compound that inhibits Hippo and Wnt signaling pathways, as well as TGF- macrophages (TGF-), exhibiting antitumor activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $113 | In Stock | |
| 5 mg | $278 | In Stock | |
| 10 mg | $446 | In Stock | |
| 25 mg | $762 | In Stock | |
| 50 mg | $1,060 | In Stock | |
| 100 mg | $1,450 | In Stock | |
| 500 mg | $2,880 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $297 | In Stock |
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Purity:99%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | EMT inhibitor-1 is a compound that inhibits Hippo and Wnt signaling pathways, as well as TGF- macrophages (TGF-), exhibiting antitumor activity. |
| In vitro | EMT inhibitor-1 (C19) inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro.EMT inhibitor-1 (C19) (0-10μM; 24 hours) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities[1]. |
| In vivo | EMT inhibitor-1 (C19) (intraperitoneal injection; 5-20 mg/kg) demonstrates significant antitumor activity in a mouse tumor model. Mechanistically, it induces GSK3-β–mediated degradation of the Hippo transducer TAZ through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK, which are upstream of the degradation complex. C19 is dissolved in the vehicle solution (100 μL of DMEM containing 5% dimethyl sulfoxide) [1]. |
| Molecular Weight | 319.21 |
| Formula | C12H12Cl2N2O2S |
| Cas No. | 1638526-21-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90 mg/mL (281.9 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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