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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $135 | In Stock | |
2 mg | $196 | In Stock | |
5 mg | $339 | In Stock | |
10 mg | $538 | In Stock | |
25 mg | $868 | In Stock | |
50 mg | $1,180 | In Stock | |
100 mg | $1,590 | In Stock | |
500 mg | $3,230 | In Stock | |
1 mL x 10 mM (in DMSO) | $373 | In Stock |
Description | EMT inhibitor-1 is an inhibitor of Hippo, Wnt signaling and TGF- macrophages (TGF-) with antitumor activity. |
In vitro | EMT inhibitor-1 (C19) inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro.EMT inhibitor-1 (C19) (0-10μM; 24 hours) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities[1]. |
In vivo | EMT inhibitor-1 (C19) (intraperitoneal injection; 5-20 mg/kg) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex.C19 is dissolved in the vehicle solution (100 μL of DMEM containing 5% dimethyl sulfoxide)[1]. |
Molecular Weight | 319.21 |
Formula | C12H12Cl2N2O2S |
Cas No. | 1638526-21-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90mg/mL (281.9mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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