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EMT inhibitor-1 is a compound that inhibits Hippo and Wnt signaling pathways, as well as TGF- macrophages (TGF-), exhibiting antitumor activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 107 € | In Stock | |
5 mg | 264 € | In Stock | |
10 mg | 423 € | In Stock | |
25 mg | 723 € | In Stock | |
50 mg | 1.007 € | In Stock | |
100 mg | 1.377 € | In Stock | |
500 mg | 2.736 € | In Stock | |
1 mL x 10 mM (in DMSO) | 282 € | In Stock |
Description | EMT inhibitor-1 is a compound that inhibits Hippo and Wnt signaling pathways, as well as TGF- macrophages (TGF-), exhibiting antitumor activity. |
In vitro | EMT inhibitor-1 (C19) inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro.EMT inhibitor-1 (C19) (0-10μM; 24 hours) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities[1]. |
In vivo | EMT inhibitor-1 (C19) (intraperitoneal injection; 5-20 mg/kg) demonstrates significant antitumor activity in a mouse tumor model. Mechanistically, it induces GSK3-β–mediated degradation of the Hippo transducer TAZ through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK, which are upstream of the degradation complex. C19 is dissolved in the vehicle solution (100 μL of DMEM containing 5% dimethyl sulfoxide) [1]. |
Molecular Weight | 319.21 |
Formula | C12H12Cl2N2O2S |
Cas No. | 1638526-21-2 |
Smiles | OCCCCOc1nsnc1-c1ccc(Cl)c(Cl)c1 |
Relative Density. | 1.415 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90 mg/mL (281.9 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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