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Cancer Cell Differentiation Compound Library

Catalog No. L2140
  Library Compound List   Excel SDF

Cell differentiation is a multifaceted process that depends on complex regulatory networks that involve transcriptional, post-transcriptional and epigenetic regulation of gene expression. In cancer, this describes how much or how little tumor tissue looks like the normal tissue it came from. Well-differentiated cancer cells look more like normal cells and tend to grow and spread more slowly than poorly differentiated or undifferentiated cancer cells. Differentiation is used in tumor grading systems, which are different for each type of cancer.

In addition to apoptosis resistance and cell proliferation capacities, the undifferentiated state also characterizes most cancer cells, especially leukemia cells. The induction of cancer cell differentiation is considered an alternative approach to elicit cell death and proliferation arrest. Differentiation therapy has mainly been developed to treat acute myeloid leukemia, notably with all-trans retinoic acid (ATRA). Numerous molecules from diverse natural or synthetic origins are effective alone or in association with ATRA in both in vitro and in vivo experiments. During the last two decades, pharmaceuticals and natural compounds with various chemical structures, including alkaloids, flavonoids and polyphenols, were identified as potential differentiating agents of hematopoietic pathways and osteogenesis.

TargetMol collects 413 reported compounds inducing cancer cell differentiation as Cancer Cell Differentiation Compound Library, which can be used for high throughput and high content screening for drug discovery.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • A unique collection of 413 cancer cell differentiation inducing compounds for high throughput and high content screening;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L2140)

Library Composition

PI3K (68)
p38 MAPK (50)
HDAC (43)
STAT (42)
mTOR (38)
ERK (31)
Akt (25)
GSK-3 (24)
TGF-beta/Smad (24)
DNA-PK (18)
ALK (17)
Wnt/beta-catenin (16)
ATM/ATR (15)
CDK (13)
AMPK (12)
S6 Kinase (11)
NF-κB (9)
PDK (7)
Gamma-secretase (7)
Autophagy (6)
MEK (6)
Src (5)
PKA (5)
Casein Kinase (5)
Carbonic Anhydrase (4)
PKC (4)
JAK (4)
TNF (4)
PDE (4)
DNA/RNA Synthesis (4)
Raf (3)
FGFR (3)
JNK (3)
Epigenetic Reader Domain (3)
EGFR (3)
Apoptosis (3)
Dehydrogenase (3)
COX (3)
Aurora Kinase (3)
Chk (3)
P450 (2)
MAPK (2)
IL Receptor (2)
BCL (2)
VEGFR (2)
Potassium Channel (2)
AChR (2)
PPAR (2)
Vitamin (2)
HER (2)
Bcr-Abl (2)
Caspase (2)
c-Fms (2)
PDGFR (2)
ROCK (2)
FLT (2)
Adrenergic Receptor (2)
Adenosine Receptor (2)
Tyrosine Kinases (2)
UGT (1)
Phosphatase (1)
Serine Protease (1)
Phospholipase (1)
Topoisomerase (1)
TLR (1)
SGK (1)
PTEN (1)
Retinoid Receptor (1)
Tie-2 (1)
ROS (1)
PLK (1)
5-HT Receptor (1)
PARP (1)
Estrogen/progestogen Receptor (1)
Antibacterial (1)
Antioxidant (1)
Antiviral (1)
Arginase (1)
Aromatase (1)
ATPase (1)
BACE (1)
cholecystokinin (1)
c-Kit (1)
c-Met/HGFR (1)
c-Myc (1)
DHFR (1)
DNA (1)
Fatty Acid Synthase (1)
NOS (1)
GABA Receptor (1)
GluR (1)
Hck (1)
Hedgehog/Smoothened (1)
HIF (1)
HIV Protease (1)
HSV (1)
IGF-1R (1)
IκB/IKK (1)
MELK (1)
MLK (1)
MMP (1)
NADPH (1)
Histamine Receptor (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE