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PRI-724
🥰Excellent
Catalog No. T64414Cas No. 1422253-38-0
Alias Foscenvivint, C-82 prodrug
PRI-724 is a second-generation, selective small molecule inhibitor of the β-catenin/CBP interaction.
PRI-724
🥰Excellent
Purity: 99.11%
Catalog No. T64414Alias Foscenvivint, C-82 prodrugCas No. 1422253-38-0
PRI-724 is a second-generation, selective small molecule inhibitor of the β-catenin/CBP interaction.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $42 | In Stock | |
| 5 mg | $98 | In Stock | |
| 10 mg | $156 | In Stock | |
| 25 mg | $278 | In Stock | |
| 50 mg | $446 | In Stock | |
| 100 mg | $662 | In Stock |
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Purity:99.11%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PRI-724 is a second-generation, selective small molecule inhibitor of the β-catenin/CBP interaction. |
| In vitro | METHODS: CAL27 and FaDu cells were treated with HS-173, erlotinib, and PRI-724 (0-100 μM, 48 hours), and cell viability was analyzed by resazurin assay. RESULTS The combination of PRI-724 and HS-173 synergistically reduced the viability of FaDu cells; in CAL27 cells, the best inhibitory results were observed with the mixture of PRI-724 and erlotinib. [2] |
| In vivo | METHODS: HCV transgenic mice were treated with PRI-724 (5, 20 mg/kg, intraperitoneally, once a day, for 6 weeks) intraperitoneally, and the antifibrotic activity of PRI-724 against HCV-induced liver fibrosis was evaluated. RESULTS In HCV transgenic mice, the expression of S100A4, which is controlled by CBP/β-catenin, was increased; this induction was attenuated by the administration of PRI-724, and the HCV-induced increase in hepatic hydroxyproline was also attenuated. Inhibition of CBP/β-catenin by PRI-724 is effective against HCV-induced liver fibrosis. [1] METHODS: HCV transgenic mice were treated with PRI-724 (0.1, 0.3, 1 mg/kg, subcutaneous injection, 6 weeks) to evaluate the anti-fibrotic activity of PRI-724. RESULTS PRI-724 can effectively reduce the area of collagen fibers in the liver in a dose-dependent manner and increase the expression level of Mmp8 mRNA and the number of F4/80, Ly-6C and Gr-1 positive cells. [1] |
| Alias | Foscenvivint, C-82 prodrug |
| Molecular Weight | 658.64 |
| Formula | C33H35N6O7P |
| Cas No. | 1422253-38-0 |
| Smiles | C([C@@H]1N2[C@@](N(C(NCC3=CC=CC=C3)=O)N(C)CC2=O)([C@H](C)N(CC=4C5=C(C=CC4)C=CC=N5)C1=O)[H])C6=CC=C(OP(=O)(O)O)C=C6 |
| Relative Density. | 1.48 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (83.51 mM)  Ethanol: 1.8 mg/mL (2.7 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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