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Osteogenesis Compound Library

Catalog No. L7900
  Library Compound List   Excel SDF

Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts. The equilibrium between bone formation and resorption is necessary and depends on the action of several local and systemic factors including hormones, cytokines, chemokines, and biomechanical stimulation. An imbalance between bone resorption and formation can result in bone diseases including osteoporosis. Osteoblasts are the main functional cells of bone formation and are responsible for the synthesis, secretion and mineralization of bone matrix. Osteoblasts undergo four stages of osteoblast proliferation, extracellular matrix maturation, extracellular matrix mineralization, and osteoblast apoptosis during bone formation. Many factors are involved in these stages to ultimately regulate bone formation.

Multiple signaling pathways were found to be involved in osteogenic proliferation and differentiation. Among them, BMP-SMAD, Wnt/β-Catenin, Notch, Hedgehog, MAPK, and FGF signaling pathways play the most critical roles in regulating osteogenic differentiation. Osteogenesis Compound Library from TargetMol collects 320 osteogenesis related bioactive compounds that can be used for research in bone formation and drug screening.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • A unique collection of 320 osteogenesis related compounds for high throughput and high content screening;
  • Targets several signaling pathways, such as BMP-SMAD, Notch, MAPK, Wnt/β-catenin, Hedgehog, FGF, etc.;
  • Effective tool for research in bone formation and related bone diseases, such as osteoporosis, bone tumor, etc.;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L7900)

Library Composition

p38 MAPK (72)
FGFR (71)
Wnt/beta-catenin (65)
Autophagy (61)
Apoptosis (59)
MAPK (35)
VEGFR (31)
ERK (27)
PDGFR (26)
Hedgehog/Smoothened (25)
Src (17)
JNK (16)
NF-κB (15)
c-Kit (13)
Smo (12)
FLT (11)
Endogenous Metabolite (10)
PARP (10)
Aurora Kinase (9)
CDK (9)
Caspase (7)
Antifungal (7)
TGF-beta/Smad (7)
Antibacterial (7)
Akt (7)
JAK (7)
EGFR (7)
Casein Kinase (7)
PERK (6)
STAT (6)
c-RET (6)
Raf (6)
Bcr-Abl (6)
IGF-1R (5)
c-Fms (5)
MEK (5)
ALK (5)
PKC (5)
COX (5)
S6 Kinase (5)
Reactive Oxygen Species (5)
Parasite (5)
ASK (4)
GSK-3 (4)
c-Met/HGFR (4)
TNF (4)
Porcupine (4)
BCL (4)
Ferroptosis (3)
FAK (3)
P450 (3)
AMPK (3)
DNA/RNA Synthesis (3)
Antibiotic (3)
Phosphatase (3)
PKA (3)
IL Receptor (3)
NO Synthase (2)
Tie-2 (2)
MMP (2)
Serine Protease (2)
Topoisomerase (2)
Trk receptor (2)
IκB/IKK (2)
Influenza Virus (2)
5-HT Receptor (2)
Calcium Channel (2)
HER (2)
AChE (2)
Carbonic Anhydrase (2)
Chk (2)
Antioxidant (2)
HSV (1)
Aromatase (1)
Antiviral (1)
SGK (1)
Arginase (1)
Aryl Hydrocarbon Receptor (1)
S1P Receptor (1)
Rho (1)
Ras (1)
ATPase (1)
PPAR (1)
Sodium Channel (1)
Syk (1)
Antifection (1)
TAM Receptor (1)
Androgen Receptor (1)
AhR (1)
TLR (1)
Adenosine Receptor (1)
ACK (1)
transporter (1)
AChR (1)
TRP/TRPV Channel (1)
TSH Receptor (1)
Tyrosine Kinases (1)
Virus Protease (1)
Beta Amyloid (1)
CaMK (1)
PLK (1)
GABA Receptor (1)
Histamine Receptor (1)
Hck (1)
HBV (1)
Kinesin (1)
Lipase (1)
Lipoxygenase (1)
MAGL (1)
Guanylate cyclase (1)
Glucokinase (1)
MELK (1)
Microtubule Associated (1)
Mitophagy (1)
MNK (1)
ABC (1)
mTOR (1)
Estrogen/progestogen Receptor (1)
Estrogen Receptor/ERR (1)
NOD (1)
Epigenetic Reader Domain (1)
DNA Alkylation (1)
DNA (1)
Discoidin Domain Receptor (DDR) (1)
DHFR (1)
CSF-1R (1)
P-gp (1)
Phosphorylase (1)
PI3K (1)
HIV Protease (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE