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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $2,120 | 1-2 weeks | |
50 mg | $2,780 | 1-2 weeks | |
100 mg | $3,700 | 1-2 weeks |
Description | Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudil produced large reductions in IOP in rabbits and monkeys that were sustained for at least 24 h after once daily dosing, with transient, mild hyperemia observed as the only adverse effect. |
Molecular Weight | 453.53 |
Formula | C28H27N3O3 |
Cas No. | 1254032-66-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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