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Product Introduction

Bioactivity

Description	Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium signaling, and endoplasmic reticulum
Targets&IC50	Proliferation:19.5±0.6 μM
In vitro	Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium signaling, and endoplasmic reticulum stress. Ganoderic acid F is a ganoderic acid.

Chemical Properties

Molecular Weight	570.67
Formula	C₃₂H₄₂O₉
Cas No.	98665-15-7
Smiles	[H][C@@]12CC(=O)C3=C(C(=O)[C@@H](OC(C)=O)[C@]4(C)[C@H](CC(=O)[C@@]34C)[C@H](C)CC(=O)CC(C)C(O)=O)[C@@]1(C)CCC(=O)C2(C)C
Relative Density.	1.25 g/cm3 at 20℃

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (175.23 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7523 mL	8.7616 mL	17.5233 mL	87.6163 mL
5 mM	0.3505 mL	1.7523 mL	3.5047 mL	17.5233 mL
10 mM	0.1752 mL	0.8762 mL	1.7523 mL	8.7616 mL
20 mM	0.0876 mL	0.4381 mL	0.8762 mL	4.3808 mL
50 mM	0.0350 mL	0.1752 mL	0.3505 mL	1.7523 mL
100 mM	0.0175 mL	0.0876 mL	0.1752 mL	0.8762 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

proliferationInhibitorinhibithuman,cervicalHeLaGanoderic acid Fganodericcellscarcinomaantitumorantimetastaticactivitiesacid