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Cat No. | Product Name | Synonyms | Targets |
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T27246 | EG1 | Others | |
EG1, a novel specific inhibitor of Pax2 transcription activation, targets the DNA binding domain and inhibits embryonic kidney development. | |||
T9118 | KEA1-97 | Apoptosis , Others , Caspase | |
Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M). Kea1-97 destroys the interaction between thioredoxin and caspase 3 and activates caspases without affecting the activity ... | |||
T8839 | ICCB280 | Apoptosis , Others | |
ICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavo... | |||
T9111 | 8-Azaadenosine | Adenosine deaminase | |
8-Azaadenosine, a powerful ADAR1 (ADAR1) and A-to-I editing inhibitor, effectively blocks RNA editing and suppresses proliferation, 3D growth, invasion, and migration in thyroid cancer cells. | |||
T11960 | MBM-55 | GSK-3 , MAPK , DYRK , Akt , Chk , Bcr-Abl , CDK , S6 Kinase , Aurora Kinase | |
MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. | |||
T9810 | TNIK-IN-5 | Wnt/beta-catenin | |
TNIK-IN-5 is an potent TNIK inhibitor (IC50= 0.05 μM). TNIK-IN-5 potently inhibits Wnt signaling in intact cells. TNIK-IN-5 exhibits excellent in vitro anti-colorectal cancer activity. | |||
T15681 | L-161982 | Prostaglandin Receptor | |
L-161982 is a selective antagonist of EP4 receptor. L-161982 could inhibit PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 could alleviate collagen-induced arthritis in mice. | |||
T7138 | FB23-2 | Apoptosis , Others | |
FB23-2 is a potent and selective mRNA N6-methyladenosine (m6A) demethylase FTO inhibitor(IC50 : 2.6 μM). | |||
T12115 | MSC2360844 | PI3K | |
MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM). | |||
T2055 | WS3 | EGFR , IκB/IKK | |
WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. | |||
T2282 | RPI-1 | Others , Phospholipase , c-Met/HGFR , c-RET | |
RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor. | |||
T39785L | TH5427 | NUDIX hydrolase | |
TH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM). | |||
T6641 | Rilmenidine Phosphate | Apoptosis , Adrenergic Receptor , Autophagy , Imidazoline Receptor | |
Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used to treat hypertension. | |||
T7200 | TAK-960 | PLK | |
TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively. | |||
T5345 | V-9302 | Others | |
V-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM). | |||
T13780 | MS1943 | Apoptosis , Histone Methyltransferase | |
MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM). | |||
T13996 | 1-Naphthohydroxamic acid | HDAC | |
1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid d... | |||
T8500 | VLX600 | OXPHOS , Mitochondrial Metabolism , Autophagy | |
VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosphorylation in tumor cells. | |||
T4356 | POL1-IN-1 | Compound 3A | DNA/RNA Synthesis |
POL1-IN-1 (Compound 3A) can effectively inhibit the transcription of RNA polymerase I in the A375 malignant melanoma cell line but has no effect on polymerase II. | |||
T1923 | BRD4770 | Histone Methyltransferase | |
BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence. | |||
T11438 | GNE-1858 | Others , MAPK | |
GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA). | |||
T6400 | AZD3514 | Androgen Receptor | |
AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1. | |||
T5414 | Glumetinib | SCC244 | c-Met/HGFR |
Glumetinib (SCC244) (SCC 244) is a novel potent and selective inhibitor of c-Met kinase (IC50: 0.42 nM). | |||
T3209 | AMG-337 | AMG337 | c-Met/HGFR |
AMG-337 is an effective and highly specific ATP-competitive MET kinase inhibitor. In enzymatic assays, AMG-337(AMG337) inhibits MET kinase activity (IC50: < 5 nM). | |||
T11284 | FIDAS-3 | Others , Wnt/beta-catenin , Methionine Adenosyltransferase (MAT) | |
FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities by effectively competing with S-adenosylmethionine (SAM) for ... | |||
T11285 | FIDAS-5 | Others | |
FIDAS-5, a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM, competitively inhibits S-adenosylmethionine (SAM) binding to MAT2A. It exhibits anticancer activities. | |||
T10717 | Inobrodib | CBP-IN-1 | Epigenetic Reader Domain |
Inobrodib (CBP-IN-1) is a potent inhibitor of p300/CBP bromodomain. | |||
T20533 | NNK | Nicotine-derived nitrosamine ketone | Lipoxygenase |
NNK (Nicotine-derived nitrosamine ketone) is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor. | |||
T21588 | Olomoucine | ERK , CDK | |
Olomoucine is an ATP competitive inhibitor of Cdk2/cyclin A, Cdc2/CyclinB, CDK2/CyclinE, CDK5/p35, and ERK1/p44 MAP kinase with IC50s of 7, 7, 7, 3 and 25 µM, respectively. Olomoucine regulates cell cycle and exhibits an... | |||
T13166 | TK216 | Others , DNA/RNA Synthesis | |
TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity. | |||
T2680 | NVP-BVU972 | c-Met/HGFR | |
NVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM. | |||
T28036 | MI-2-2 | MI22,MI 2 2 | Histone Methyltransferase |
MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM. | |||
T9102 | WM-3835 | Apoptosis , Histone Methyltransferase , Histone Acetyltransferase | |
WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation. | |||
T5168 | EGFR-IN-12 | EGFR Inhibitor | Apoptosis , EGFR |
EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells. | |||
T8496 | MAZ51 | Apoptosis , VEGFR | |
MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor. | |||
T15588 | Iobenguane sulfate | MIBG sulfate | Others |
Iobenguane sulfate (MIBG sulfate) is a high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation). Radioiodinated Iobenguane sulfate is clinically used as a tumor-targeted radiopharmac... | |||
T7779 | Nelfinavir | AG1341 | HIV Protease |
Nelfinavir (AG1341) is an antiretroviral drug used in the treatment of the human immunodeficiency virus (HIV) (Ki=2 nM). Nelfinavir is a broad-spectrum, anticancer agent. | |||
T3661 | Citarinostat | ACY241,HDAC-IN-2 | HDAC |
ACY-241, also known as Citarinostat (ACY241), is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the activ... | |||
T8756 | KRAS inhibitor-9 | DUN09716 | Apoptosis , Ras |
KRAS inhibitor-9 (DUN09716) is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS ... | |||
T9195 | SHR0302 | ARQ252 | Apoptosis , JAK |
SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3, 420 times for Tyk2). | |||
T8872 | (Rac)-JBJ-04-125-02 | JBJ-04-125-02 | EGFR |
(Rac)-JBJ-04-125-02 (JBJ-04-125-02) is effective as a single agent in both in vitro and in vivo models of EGFR-mutant lung cancer. | |||
T5097 | Ezatiostat | TER199(free base),TLK199 | Apoptosis , Glutathione Peroxidase , GST |
Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity. | |||
T11826 | LCH-7749944 | GNF-PF-2356 | Apoptosis , PAK |
LCH-7749944 (GNF-PF-2356) effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis. LCH-7749944 is a potent PAK4 inhibitor w... | |||
T9962 | Mepolizumab | SB 240563 | IL Receptor |
Mepolizumab (SB 240563) is a humanized monoclonal antibody neutralizing IL-5. Mepolizumab can be used in studies about severe eosinophilic asthma and eosinophilic granulomatosis with polyangiitis. | |||
T1995 | Fedratinib | TG-101348,SAR 302503 | Apoptosis , FLT , c-RET , JAK |
Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3. | |||
T8376 | PKCβ inhibitor 1 | KUN79359 | Apoptosis , PKC |
PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively). | |||
T7055 | Bz-RS-ISer(3-Ph)-Ome | Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate | Others , HIV Protease |
Bz-RS-ISer(3-Ph)-Ome (Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate) is a paclitaxel derivative that inhibits the HSV replication cycle at low cytotoxicity, blocks mitosis in Vero cells, affects the size o... | |||
T6203 | Saxagliptin | BMS-477118,Onglyza | Proteasome , DPP-4 |
Saxagliptin (BMS-477118) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM. | |||
T6941 | PI-1840 | PI 1840 | PARP , Proteasome |
PI-1840(IC50 = 27 nM)is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L). | |||
T6351 | MGCD-265 analog | MGCD-265,Glesatinib | Apoptosis , VEGFR , c-Met/HGFR |
MGCD-265 analog (Glesatinib) is an orally bioavailable multitargeted tyrosine kinase inhibitor with potential antineoplastic activity with IC50 of 29 nM and 10 nM for c-Met and VEGFR2, respectively. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1768 | Iriflophenone | Estrogen Receptor/ERR , Estrogen/progestogen Receptor | |
Iriflophenone stimulates cells proliferation in MCF-7 and T-47D human breast cancer. | |||
TN2054 | Periplocymarin | Calcium Channel | |
Periplocymarin is a cardiac glycoside with anticancer potential isolated from Periploca sepium and Periploca graeca. | |||
T3855 | Tracheloside | Estrogen Receptor/ERR , Phosphorylase | |
Tracheloside significantly decreases the activity of alkaline phosphatase (IC50: 0.31 μg/ml), a level of inhibition comparable to that of tamoxifen (IC50: 0.43 μg/ml). | |||
TN1124 | Neoeriocitrin | AChE | |
Neoeriocitrin is a natural product isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor. | |||
TN6739 | Angoline | 6-Methoxyldihydrochelerythrine | IL Receptor , STAT |
Angoline (6-Methoxyldihydrochelerythrine) hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits can... | |||
T3881 | Vaccarin | Integrin , Akt , PERK , AMPK | |
Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation. | |||
T11363 | Ganoderic acid F | Others | |
Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium si... | |||
TN2190 | Scoulerine | Apoptosis , Beta-Secretase , BACE , Parasite | |
Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells. | |||
T8716 | Physalin F | Apoptosis | |
Physalin F is a natural blocker of CaV2.3 (R-type) and CaV2.2 (N-type) voltage-gated calcium channels.It is a secosteroid with potent anti-inflammatory and immunomodulatory activities. Physalin F induces apoptosis of PBM... | |||
T0950 | Neomycin sulfate | Framycin sulfate | Phospholipase , ribosome , Antibacterial , Antibiotic |
Neomycin sulfate (Framycin sulfate) is a broad-spectrum aminoglycoside antibiotic that blocks the synthesis of bacterial proteins in order to exert antimicrobial activity. Neomycin sulfate is commonly used to screen prok... | |||
T6670 | Silymarin | Silybin B | SARS-CoV |
Silymarin (Silybin B) (Silybin B) is a polyphenolic flavonoid that extracts from the milk thistle or seeds of Silybum marianum. It is used in the prevention and treatment of liver diseases. | |||
T5724 | Neogambogic acid | neo-gambogic acid | Apoptosis , Others , Antibacterial |
Neogambogic acid, an active ingredient in garcinia, can inhibit the growth of some solid tumors and result in an anticancer effect, it may be responsible for the inhibition of proliferation of human breast cancer cell li... | |||
T0131 | Cepharanthine | NSC-623442 | Apoptosis , TNF , HIV Protease , Autophagy |
Cepharanthine (NSC-623442), a biscoclaurine alkaloid, suppresses tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and inhibits cytokine production. | |||
T1644 | Dopamine hydrochloride | Dopamine HCl,ASL279 | Ferroptosis , Dopamine Receptor , 5-HT Receptor , Endogenous Metabolite |
Dopamine hydrochloride (ASL279) is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine hydrochloride binds to alpha-1- and b... | |||
T8846 | Beta-Escin | B-escin,AESCINE | Immunology/Inflammation related |
beta-Escin is a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent. | |||
TN1237 | 3-O-Methylgallic acid | 3,4-Dihydroxy-5-methoxybenzoic acid | Apoptosis , NF-κB , OCT , DNA/RNA Synthesis , STAT |
3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may offer protection against colon cancer after its formation ... | |||
T2988 | (-)-Epigallocatechin Gallate | Epigallocatechol Gallate,EGCG | Ferroptosis , Reactive Oxygen Species , HIV Protease , Mitochondrial Metabolism , Endogenous Metabolite , Autophagy |
(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate (EGCG) blocks the activation of EGF receptors and HER-2 receptor... | |||
T22455 | Vindesine sulfate | DVA,Desacetylvinblastine amide,DAVA,Desacetyl Vinblastine amide,VDS | Others |
Vindesine sulfate (Desacetyl Vinblastine amide) is a vinca alkaloid which is a synthetic derivative of vinblastine, binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule... | |||
T0687 | Simvastatin | MK-0733,MK 733 | Apoptosis , Mitophagy , Ferroptosis , HMG-CoA Reductase , Autophagy |
Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cholesterol, and is also used for the prevention of cardiovasc... | |||
T12581 | Puerarin-4'-O-β-D-glucopyranoside | Puerarin4'-O-glucoside | Others |
Puerarin-4'-O-β-D-glucopyranoside (Puerarin4'-O-glucoside) is a natural product isolated from Pueraria lobata root having estrogenic activity and anti-proliferation in MCF-7 human breast carcinoma cells. | |||
T6S1101 | Astragalin | Kaempferol 3-D-glucoside,Kaempferol 3-O-glucoside,kaempferol-3-glucoside,3-Glucosylkaempferol,Astragaline,Kaempferol 3-β-D-glucopyranoside | Apoptosis , NF-κB |
Astragalin (Kaempferol 3-O-glucoside) is a biologically active natural flavonoid. It has a variety of pharmacological properties, including antioxidant, anti-inflammatory, anti-cancer, neuroprotective, and cardioprotecti... | |||
T3398 | Icaritin | Anhydroicaritin,Cycloicaritin | Apoptosis , JAK , STAT , Autophagy |
Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation. Ica... | |||
T38815 | Millepachine | Apoptosis | |
Millepachine is a natural product found in the Chinese herbal medicine with strong antitumor effects against numerous human cancer cells. | |||
T22644 | C2 Ceramide | Ceramide | Others |
A potent modulator of cell proliferation and differentiation. | |||
T0190 | Vinorelbine | KW-2307 base | Microtubule Associated |
Vinorelbine (KW-2307 base) is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. | |||
TN1443 | Biorobin | Kaempferol 3-O-robinobioside | |
Biorobin (Kaempferol 3-O-robinobioside) significantly inhibits human lymphocyte proliferation in vitro. | |||
TN2088 | Platycodin D2 | IL Receptor , HBV | |
Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice, it could be safely used as adjuvant eliciting Th1 and Th2 immune responses. Polygalaci... | |||
TMA1122 | N-Feruloylserotonin | (E/Z)-Moschamine,Moschamine | Antioxidant |
N-Feruloylserotonin ((E/Z)-Moschamine) is a selective FAAH inhibitor that inhibits [H]-AEA uptake and cell proliferation at low concentrations. | |||
TN1697 | Glucosyringic acid | Immunology/Inflammation related | |
Glucosyringic acid has immunosuppressive effect, it can inhibit the proliferation of murine B lymphocytes in vitro. | |||
T0938 | Thiabendazole | 2-(4-Thiazolyl)benzimidazole | Microtubule Associated , Mitochondrial Metabolism , Parasite |
Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property. | |||
T12971 | Solanidine | Others | |
Solanidine is a cholestane alkaloid isolated from potato species with antitumor effects. Solanidine inhibits proliferation. | |||
T3250 | Royal Jelly acid | 10-Hydroxy-trans-2-decenoic acid,10-Hydroxy-2-decenoic acid,10H2DA,10-Hydroxy-2-decylenic acid,Queen Bee Acid,(E)-10-Hydroxy-2-decenoic acid | VEGFR , Endogenous Metabolite |
Royal Jelly acid (Queen Bee Acid) is an inhibitor of VEGF-induced angiogenesis, cell migration and proliferation. | |||
T3S2325 | Ardisiacrispin A | Saxifragifolin B,LTS-4,Deglucocyclamin | HSV |
Ardisiacrispin A (Deglucocyclamin) has cytotoxic activity toward HepG2 cancer cell with the GI(50) value of 1.56μM, it could inhibit the proliferation of Bel-7402 cells by inducing apoptosis and disassembling microtubule... | |||
T2S1837 | Steviol | NSC 226902,Hydroxydehydrostevic acid | Others |
1. Steviol (NSC-226902), a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. 2. Steviol can induce a significant increase in CYP3A29 expression. 3. Steviol inhibits the prolif... | |||
T6S1843 | Tenacissoside I | Tenacissimoside B | Others |
Tenacissoside I (Tenacissimoside B),Tenacissosides B, C and marsdenoside K inhibit the proliferation of Raji, NB4 and K562 cells in vitro significantly, in a dose and time dependent manner. | |||
T3806 | Kaempferide | Kaempferol 4'-O-methyl ether,Kaempferol 4'-methyl ether,4'-Methylkaempferol,4'-O-Methylkaempferol | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Influenza Virus , Antibacterial , Autophagy |
kaempferide (4'-Methylkaempferol) inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by ligand binding dependent estrogen receptor activatio... | |||
TN2304 | Vitexin 2''-O-p-coumarate | Vitexin2''-O-p-coumarate,Vitexin 2''-O-p-coumarate | Others |
Vitexin 2''-O-p-coumarate (Vitexin2''-O-p-coumarate) is found in fenugreek seeds and promotes 2BS cell proliferation induced by H2O2. | |||
TN1683 | Gentisin | DNA/RNA Synthesis | |
Gentisin is a novel inhibitor of vascular smooth muscle cells (VSMC) proliferation with an IC50 value of 7.84 μM. Gentisin has mutagenic activity. | |||
TN2058 | Persicogenin | Anti-infection | |
Persicogenin has anticancer, antimutagenic, and antileishmanial activities, it can inhibit the proliferation of mouse tsFT210 cancer cells, it mainly inhibits cell cycle at the G2/M phase in a dose-dependent manner. | |||
TQ0214 | Dimethylcurcumin | ASC-J9,GO-Y025 | Androgen Receptor |
Dimethylcurcumin (ASC-J9) (ASC-J9) is an androgen receptor degradation enhancer. It effectively suppresses castration-resistant prostate cancer cell proliferation and invasion. | |||
T2848 | Osthole | Osthol,NSC 31868,Ostol | Apoptosis , HBV , Parasite , Histamine Receptor |
Osthole (Osthol), a potential inhibitor of histamine H1 receptor, has been shown to stimulate osteoblast proliferation and differentiation. | |||
TN1148 | Isopsoralenoside | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Antibacterial | |
Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects. | |||
T9144 | Telekin | Others | |
Telekin, a eudesmane-type sesquiterpene lactone compound isolated from Chinese folk medicine Carpesium divaricatum, has been reported to strongly inhibit the proliferation of cancer cells | |||
T5S1882 | Songorine | Napellonine,Zongorine,Bullatine G | Others , GABA Receptor |
Songorine (Napellonine) shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays. | |||
T5809 | Stachyose hydrate | Stachyose | Others |
Stachyose hydrate is a natual product,it highly promotes proliferation of lactic acid bacteria (LAB) by inducing LAB to produce more α-galactosidase to hydrolyze stachyose. | |||
T3871 | Daucosterol | Alexandrin,Sitogluside,β-Sitosterol β-D-glucoside,Eleutheroside A | Glucosidase |
Daucosterol (Sitogluside) has proliferation-enhancing activity, may be involved in the IGF1-AKT pathway. Daucosterol(β-Sitosterol β-D-glucoside) has efficient and inexpensive neuroprotectant effect, to contribute to IGF1... | |||
TN2018 | Orientin-2''-O-p-trans-coumarate | Others | |
Orientin-2''-O-p-trans-coumarate is isolated from Trigonella foenum-graecum. Orientin-2''-O-p-trans-coumarate shows antioxidant activity and promotes cell proliferation. | |||
T3805 | Prim-O-glucosylcimifugin | Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside | TNF , COX , JAK , NO Synthase |
Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0/G1 phase. | |||
T5793 | Britannin | Apoptosis , AMPK , Autophagy | |
Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells. | |||
T5S0777 | Phellodendrine chloride | Others | |
Phellodendrine chloride has anti-nephritic activity, may be due to its ability to inhibit the proliferation or the migration of macrophages and cytotoxic T lymphocytes in the glomeruli. | |||
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Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00137 | APRIL/TNFSF13 Protein, Human, Recombinant (Flag & His) | Human | Human Cells |
APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to relea... | |||
TMPH-01029 | CAPN1 Protein, Human, Recombinant (His) | Human | E. coli |
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His... | |||
TMPY-01557 | MAGOH Protein, Human, Recombinant (His) | Human | E. coli |
MAGOH (Mago Homolog, Exon Junction Complex Subunit) is a Protein Coding gene. MAGOH is the human homolog of Drosophila mago nashi, a protein that is required for normal germplasm development in the Drosophila embryo. In ... | |||
TMPY-02844 | EBP1 Protein, Human, Recombinant (His) | Human | E. coli |
EBP1, also known as PA2G4, is an RNA-binding protein that belongs to the peptidase M24 family. It can be detected n several cell lines tested, including primary and transformed cell lines. EBP1 also present in pre-riboso... | |||
TMPY-03105 | Ki67/MKI67 Protein, Human, Recombinant (GST) | Human | E. coli |
MKI67 contains 1 FHA domain and plays a key role in cell proliferation. During interphase, the MKI67 antigen can be exclusively detected within the cell nucleus, whereas in mitosis most of the protein is relocated to the... | |||
TMPJ-00456 | APRIL/TNFSF13 Protein, Mouse, Recombinant (hFc) | Mouse | Human Cells |
Tumor necrosis factor ligand superfamily member 13 belongs to the tumor necrosis factor family. It is also known as APRIL, TALL2, TRDL1, and CD256. It is synthesized as a 32 kDa proprotein which is cleaved by furin in th... | |||
TMPJ-00761 | FTH Protein, Human, Recombinant (His) | Human | E. coli |
Ferritin heavy polypeptide 1(FTH1), is a ubiquitous intracellular protein which stores iron in a soluble, non-toxic, readily available form. FTH1 has ferroxidase activity and is important for iron homeostasis. Iron is ta... | |||
TMPY-04021 | NPDC1 Protein, Human, Recombinant (His) | Human | HEK293 |
TMPJ-01404 | TMX2 Protein, Human, Recombinant (His) | Human | E. coli |
TMX2 is a single-pass type I membrane protein and contains 1 thioredoxin domain. Thioredoxin plays an important role in various cellular processes through redox regulation. The Molecular Cloning and characterization of ... | |||
TMPH-01299 | EMC4 Protein, Human, Recombinant (His) | Human | in vitro E. coli expression system |
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates prot... | |||
TMPJ-00724 | LDHA Protein, Human, Recombinant (His) | Human | E. coli |
L-Lactate Dehydrogenase A Chain (LDHA) is an enzyme that catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA contains an N-terminal coenzyme binding region,... | |||
TMPH-02557 | CAPN1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-388' and 'His... | |||
TMPJ-00995 | Serpin H1 Protein, Human, Recombinant (His) | Human | Human Cells |
Serpin H1 is a serine proteinase inhibitors Which belongs to the serpin family. Serpin H1 is induced by heat shock. Serpin H1 localizes to the endoplasmic reticulum lumen and binds specifically to collagen. Thus it is th... | |||
TMPH-01036 | Caprin-1/CAPRIN1 Protein, Human, Recombinant (His) | Human | Baculovirus |
May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs... | |||
TMPK-00305 | TGFBR1 Protein, Human, Recombinant (mFc & Avi) | Human | HEK293 |
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup... | |||
TMPJ-00412 | VEGFR1/FLT-1 Protein, Human, Recombinant (hFc) | Human | Human Cells |
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 ... | |||
TMPY-02626 | FGF-18 Protein, Human, Recombinant (His) | Human | HEK293 |
Fibroblast growth factor 18 (FGF18) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes... | |||
TMPY-03945 | Latent TGF beta 1 Protein, Rat, Recombinant (His) | Rat | HEK293 |
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d... | |||
TMPY-04211 | Latent TGF beta 1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d... | |||
TMPY-00608 | TGF beta 1 Protein, Rat/Mouse, Recombinant | Mouse,Rat | HEK293 |
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d... | |||
TMPY-03564 | TSPAN8 Protein, Human, Recombinant (His) | Human | HEK293 |
Tetraspanin 8 (TSPAN8) as an important modulator of melanoma invasiveness, and several of its transcriptional regulators, which affect TSPAN8 expression during melanoma progression toward an invasive stage. p53 as a nega... | |||
TMPY-02638 | TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant | Human,Rhesus,Cynomolgus,Canine | CHO |
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d... | |||
TMPY-01133 | Latent TGF beta 1 Protein, Human, Recombinant (His) | Human | HEK293 |
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d... | |||
TMPY-00500 | Latent TGF beta 1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d... | |||
TMPY-06842 | BMP-4 Protein, Human, Recombinant (E399D) | Human | E. coli |
BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP... | |||
TMPJ-00562 | PDGF-BB Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (P... | |||
TMPY-00365 | GALNT7 Protein, Human, Recombinant (His) | Human | HEK293 |
GalNAc-transferase-7 (GALNT7) is essential for the regulation of cell proliferation and has been implicated in tumorigenesis. Colorectal cancer (CRC) arises in a multistep molecular network process, which is from either ... | |||
TMPY-00854 | IL-1 alpha/IL-1A Protein, Human, Recombinant | Human | HEK293 |
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli... | |||
TMPY-00972 | FGFR2 Protein, Human, Recombinant (His & hFc) | Human | HEK293 |
FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibro... | |||
TMPJ-01470 | SCF Protein, Human, Recombinant | Human | E.coli |
Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultu... | |||
TMPY-03383 | IL-7 Protein, Human, Recombinant | Human | E. coli |
IL7, also known as interleukin 7, is a hematopoietic growth factor that belongs to the IL-7/IL-9 family. It is secreted by stromal cells in the bone marrow and thymus. IL7 stimulates the proliferation of lymphoid progeni... | |||
TMPJ-00059 | IL-7 Protein, Human, Recombinant (His) | Human | Human Cells |
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions... | |||
TMPY-00524 | IL-7 Protein, Mouse, Recombinant | Mouse | E. coli |
IL7, also known as interleukin 7, is a hematopoietic growth factor that belongs to the IL-7/IL-9 family. It is secreted by stromal cells in the bone marrow and thymus. IL7 stimulates the proliferation of lymphoid progeni... | |||
TMPY-00423 | FGFR2 Protein, Human, Recombinant (alpha IIIb, hFc) | Human | HEK293 |
FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibro... | |||
TMPY-06981 | IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli) | Human | E. coli |
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli... | |||
TMPY-01738 | IL-1 alpha/IL-1A Protein, Mouse, Recombinant | Mouse | E. coli |
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli... | |||
TMPY-03357 | FGFR2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibro... | |||
TMPK-00831 | Galectin-3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Galectin-3 (Gal-3) is a 30 kDa β-galactose, highly conserved and widely distributed intracellularly and extracellularly. Gal-3 has been demonstrated in recent years to be a novel inflammatory factor participating in the ... | |||
TMPY-01827 | CD30/TNFRSF8 Protein, Human, Recombinant (His) | Human | HEK293 |
CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of... | |||
TMPJ-00038 | IL-7 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Mouse interleukin-7(IL-7) is the member of hemopoietin family which is important to the differentiation, proliferation, and survival of lymphocyte. Mouse IL-7 shares approximately 88% aa sequence identity with rat IL-7 a... | |||
TMPJ-00335 | TGFBR2 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β regulates cellular processes by binding to three high-affinit... | |||
TMPJ-01467 | Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His) | Human | E.coli |
Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM encodes a growth regulator, ... | |||
TMPY-02105 | SCF Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
Similar to Kit ligand precursor (C-kit ligand), also known as Stem cell factor (SCF), Mast cell growth factor (MGF), or Hematopoietic growth factor KL. SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encod... | |||
TMPY-03722 | EpCAM/TROP1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane d... | |||
TMPY-02170 | SCF Protein, Human, Recombinant (aa 1-189, His) | Human | Baculovirus-Insect Cells |
Similar to Kit ligand precursor (C-kit ligand), also known as Stem cell factor (SCF), Mast cell growth factor (MGF), or Hematopoietic growth factor KL. SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encod... | |||
TMPJ-00071 | EPO/Erythropoietin Protein, Human, Recombinant (His) | Human | Human Cells |
Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoi... | |||
TMPY-05587 | EpCAM/TROP1 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane d... | |||
TMPJ-00235 | TPO Protein, Human, Recombinant (His) | Human | Human Cells |
Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets. TPO stimulates the production and differentiation of me... | |||
TMPY-04830 | GAS6 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin ... | |||
TMPY-05242 | CRLF2/TSLPR Protein, Human, Recombinant (His) | Human | HEK293 |
Overexpression of cytokine receptor-like factor 2 (CRLF2) due to chromosomal rearrangement has been observed in acute lymphoblastic leukemia (ALL) and reported to contribute to oncogenesis and unfavorable outcome in ALL.... | |||
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Cat No. | Product Name | ||
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L2140 | Cancer Cell Differentiation Compound Library | 413 compounds | |
A unique collection of 413 cancer cell differentiation inducing compounds for high throughput and high content screening; | |||
L7900 | Osteogenesis Compound Library | 320 compounds | |
A unique collection of 320 osteogenesis related compounds for high throughput and high content screening; | |||
L4300 | Wnt/Hedgehog/Notch Compound Library | 240 compounds | |
A unique collection of 240 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening; | |||
L2151 | Chemotherapy Drug Library | 51 compounds | |
51 Chemotherapeutic drugs that can be used for high-throughput and high-content screening. | |||
L6100 | Polyphenolic Natural Product Library | 640 compounds | |
A unique collection of 640 natural polyphenolic compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L1400 | MAPK Inhibitor Library | 367 compounds | |
A unique collection of 367 compounds targeting MAPK signaling for drug discovery in MAPK related diseases; | |||
L2200 | Tyrosine Kinase Inhibitor Library | 1033 compounds | |
A unique collection of 1033 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases; | |||
L6730 | Anti-virus Traditional Chinese Medicine Monomer Library | 270 compounds | |
A collection of 270 TCM monomers with anti-virus activity. An effective tool for drug development and pharmacological studies. | |||
L4000 | Bioactive Compound Library | 14590 compounds | |
A collection of 14590 small molecule compounds with validated activity for high throughput screening (HTS), high content screening (HCS), cell induction, and target identification; | |||
L6140 | Saccharide and Glycoside Natural Product Library | 364 compounds | |
A unique collection of 364 saccharides and glycosides compounds can be used for HTS and HCS; | |||
L1300 | PI3K-AKT-mTOR Compound Library | 425 compounds | |
A unique collection of 425 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling; | |||
L2130 | Anti-Cancer Metabolism Compound Library | 1280 compounds | |
A unique collection of 1280 cancer cellular metabolism related compounds for cancer research and high throughput screening (HTS) and high content screening (HCS); | |||
L2600 | Neuronal Signaling Compound Library | 2540 compounds | |
A unique collection of 2540 compounds targeting CNS signaling for high throughput screening (HTS) and high content screening (HCS) for new drugs; | |||
L5300 | Mitochondria-Targeted Compound Library | 830 compounds | |
A unique collection of 830 promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for research in mitochondrial medicine; | |||
L6740 | Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library | 386 compounds | |
A collection of 386 TCM monomers with anti-colorectal activity. An effective tool for drug development and pharmacological studies. | |||
L6750 | PBCRBS Traditional Chinese Medicine Compound Library | 588 compounds | |
A unique collection of 588 compounds derived from traditional Chinese medicines (TCMs) for promoting blood circulation and removing blood stasis. |