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PROTAC SGK3 degrader-1

Catalog No. T13847Cas No. 2381320-35-8

PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, which induces degradation of endogenous SGK3.PROTAC SGK3 degrader-1 inhibits GDC0941-induced proliferation of cancer cells.CAS 번호5017-88-83-4

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Pack Size	Price	Availability
1 mg	$479	Backorder
5 mg	$977	Backorder
25 mg	$2,280	Backorder
50 mg	$2,970	Backorder
1 mL x 10 mM (in DMSO)	$39	Backorder

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Product Introduction

Bioactivity

Description	PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, which induces degradation of endogenous SGK3.PROTAC SGK3 degrader-1 inhibits GDC0941-induced proliferation of cancer cells.CAS 번호5017-88-83-4
In vitro	SGK3-PROTAC1 (0.3 μM) induces endogenous SGK3 degradation by 50% within 2 hours, with maximal degradation of 80% observed within 8 hours, accompanied by loss of phosphorylation of SGK3 substrate NDRG1[1].
Alias	SGK3-PROTAC1

Chemical Properties

Molecular Weight	1157.38
Formula	C57H73FN10O11S2
Cas No.	2381320-35-8

Storage & Solubility Information

Storage

store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (69.12 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8640 mL	4.3201 mL	8.6402 mL	43.2010 mL
5 mM	0.1728 mL	0.8640 mL	1.7280 mL	8.6402 mL
10 mM	0.0864 mL	0.4320 mL	0.8640 mL	4.3201 mL
20 mM	0.0432 mL	0.2160 mL	0.4320 mL	2.1601 mL
50 mM	0.0173 mL	0.0864 mL	0.1728 mL	0.8640 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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