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PROTAC SGK3 degrader-1
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Catalog No. T13847Cas No. 2381320-35-8
Alias SGK3-PROTAC1
PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, inducing degradation of endogenous SGK3. It inhibits GDC0941-induced proliferation of cancer cells. [5017-88-83-4]
PROTAC SGK3 degrader-1
😃Good
Catalog No. T13847Alias SGK3-PROTAC1Cas No. 2381320-35-8
PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, inducing degradation of endogenous SGK3. It inhibits GDC0941-induced proliferation of cancer cells. [5017-88-83-4]
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $479 | Backorder | |
| 5 mg | $977 | Backorder | |
| 25 mg | $2,280 | Backorder | |
| 50 mg | $2,970 | Backorder | |
| 1 mL x 10 mM (in DMSO) | $39 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, inducing degradation of endogenous SGK3. It inhibits GDC0941-induced proliferation of cancer cells. [5017-88-83-4] |
| In vitro | SGK3-PROTAC1 (0.3 μM) induces endogenous SGK3 degradation by 50% within 2 hours, with maximal degradation of 80% observed within 8 hours, accompanied by loss of phosphorylation of SGK3 substrate NDRG1[1]. |
| Alias | SGK3-PROTAC1 |
| Molecular Weight | 1157.38 |
| Formula | C57H73FN10O11S2 |
| Cas No. | 2381320-35-8 |
| Relative Density. | 1.309 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (69.12 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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