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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $265 | In Stock | |
5 mg | $657 | In Stock | |
10 mg | $935 | In Stock | |
25 mg | $1,390 | In Stock | |
50 mg | $1,890 | In Stock | |
1 mL x 10 mM (in DMSO) | $896 | In Stock |
Description | ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer. |
In vitro | ARV-471 robustly degrades ER with a DC50 of 2 nM in ER-positive breast cancer cell lines[1]. |
In vivo | ARV-471 degrades rat uterine ER and demonstrates no agonist activity in an immature rat uterotrophic model. ARV-471 (3, 10, and 30 mpk; oral) leads to significant tumor volume regressions of estradiol-dependent MCF7 xenografts and concomitant tumor ER protein reductions of >90% at study termination[1]. |
Alias | Vepdegestrant |
Molecular Weight | 723.9 |
Formula | C45H49N5O4 |
Cas No. | 2229711-68-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (138.14 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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