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CCT367766

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Purity:100%

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COA HNMR HPLC LCMS

CCT367766

Catalog No. T14908Cas No. 2229856-58-8

CCT367766 is a potent, PROTAC-based, third-generation, iso-functional pirin-targeted protein degradation probe (PDP) that depletes pirin expression at low concentrations.CCT367766 has an IC50 value of 490 nM for the CRBN-DDB1 complex.CCT367766 has a good affinity for recombinant pirin and CRBN. CCT367766 has a good affinity for recombinant pirin and CRBN, with Kd values of 55 nM and 120 nM, respectively. cct367766 is a potent orally active protein that reduces the expression of pirin at low concentrations.

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25 mg	$1,520	Backorder

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Product Introduction

Bioactivity

Description	CCT367766 is a potent, PROTAC-based, third-generation, iso-functional pirin-targeted protein degradation probe (PDP) that depletes pirin expression at low concentrations.CCT367766 has an IC50 value of 490 nM for the CRBN-DDB1 complex.CCT367766 has a good affinity for recombinant pirin and CRBN. CCT367766 has a good affinity for recombinant pirin and CRBN, with Kd values of 55 nM and 120 nM, respectively. cct367766 is a potent orally active protein that reduces the expression of pirin at low concentrations.
Targets&IC50	CRBN-DDB1:490 nM
In vitro	CCT367766 (0.5-50 nM; 2 h) demonstrates the concentration-dependent depletion of Pirin protein after 2 h exposure in SK-OV-3 cells.[1] CCT367766 (0.5-50 nM; 2 h) dose-dependently rescues pirin expression from pretreatment of chlorobisamide in SK-OV-3 cells.[1] CCT367766 (50-1500 nM; 24 h) demonstrates the depletion of Pirin protein as a time-dependent hook effect in SK-OV-3 human ovarian cancer cells.[1]

Chemical Properties

Molecular Weight	946.4
Formula	C49H48ClN7O11
Cas No.	2229856-58-8

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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