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CCT367766 formic
CCT367766 formic
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CCT367766 formic
Catalog No. T77915
CCT367766 formic is a potent third-generation heterobifunctional Cereblon-based protein degradation probe (PDP, or PROTAC) that selectively targets pirin for degradation, effectively diminishing its protein expression at low concentrations. This compound demonstrates moderate affinity towards the CRBN-DDB1 complex, as denoted by an IC50 value of 490 nM, while exhibiting strong binding to recombinant pirin and CRBN, with respective Kd values of 55 nM and 120 nM. As such, CCT367766 formic serves as a valuable chemical probe for investigating the functions of the largely unexplored pirin protein [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CCT367766 formic is a potent third-generation heterobifunctional Cereblon-based protein degradation probe (PDP, or PROTAC) that selectively targets pirin for degradation, effectively diminishing its protein expression at low concentrations. This compound demonstrates moderate affinity towards the CRBN-DDB1 complex, as denoted by an IC50 value of 490 nM, while exhibiting strong binding to recombinant pirin and CRBN, with respective Kd values of 55 nM and 120 nM. As such, CCT367766 formic serves as a valuable chemical probe for investigating the functions of the largely unexplored pirin protein [1]. |
| In vitro | CCT367766 formic at concentrations ranging from 50 to 1500 nM over 24 hours exhibits time-dependent diminishment of pirin protein levels, echoing a hook effect in SK-OV-3 human ovarian cancer cells [1]. At lower doses (0.5-50 nM for 2 hours), CCT367766 formic causes a concentration-dependent reduction of pirin protein in these cells [1]. Furthermore, the same dosage range over a 2-hour period can counteract the suppression effect of chlorobisamide pretreatment on pirin protein levels in SK-OV-3 cells [1]. |
| Molecular Weight | 992.42 |
| Formula | C50H50ClN7O13 |
| Cas No. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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