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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $45 | In Stock | |
100 mg | $58 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Cepharanthine (NSC-623442), a biscoclaurine alkaloid, suppresses tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and inhibits cytokine production. |
In vitro | In a xenograft model using SAOS2 cells in athymic mice, daily treatment with Cepharanthine (20 mg/kg) significantly reduced tumor volume and weight. |
In vivo | In SaOS2 cells, Cepharanthine (2.5–20 μmol/L) inhibits cell growth in a concentration- and time-dependent manner. At concentrations of 5–10 μmol/L, Cepharanthine markedly suppresses the expression of STAT3 target genes, including the anti-apoptotic gene Bcl-xL and cell cycle regulators c-Myc and cyclin D1. At 10 μmol/L, Cepharanthine induces a cell cycle arrest at the G1 phase and promotes apoptosis in SaOS2 cells. Furthermore, Cepharanthine (10–15 μmol/L) significantly reduces STAT3 expression in SAOS2 cells. |
Alias | NSC-623442 |
Molecular Weight | 606.71 |
Formula | C37H38N2O6 |
Cas No. | 481-49-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 50 mg/mL (82.41 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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