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CDDD11-8

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Catalog No. T86025Cas No. 2241659-94-7

CDDD11-8 is an orally administered, highly potent and selective CDK9 and FLT3-ITD inhibitor, with K i values of 8 nM and 13 nM, respectively. It effectively reduces the proliferation of leukemia cell lines, showing particular efficacy against those with the FLT3-ITD mutation [1] [2].

CDDD11-8

CDDD11-8

😃Good
Catalog No. T86025Cas No. 2241659-94-7
CDDD11-8 is an orally administered, highly potent and selective CDK9 and FLT3-ITD inhibitor, with K i values of 8 nM and 13 nM, respectively. It effectively reduces the proliferation of leukemia cell lines, showing particular efficacy against those with the FLT3-ITD mutation [1] [2].
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10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
CDDD11-8 is an orally administered, highly potent and selective CDK9 and FLT3-ITD inhibitor, with K i values of 8 nM and 13 nM, respectively. It effectively reduces the proliferation of leukemia cell lines, showing particular efficacy against those with the FLT3-ITD mutation [1] [2].
Targets&IC50
CDK9:8 nM (Ki)
In vivo
CDDD11-8 administered orally at doses between 0 to 125 mg/kg daily can induce tumor regression [1]. In an animal model using MV4-11 tumor-bearing mice [1], the compound was tested at dosages of either 75 or 125 mg/kg. The administration was carried out orally on a daily basis for either 5 or 28 days. Results confirmed potent inhibition of CDK9 in vivo, as evidenced by the reduced phosphorylation of RNAPII at Ser2 and Ser5. Moreover, a decrease in the phosphorylation of FLT3 at Tyr591 and STAT5 at Tyr694 was observed, affirming the compound's effectiveness.
Chemical Properties
Molecular Weight398.5
FormulaC24H26N6
Cas No.2241659-94-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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