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GA-017

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Purity:98.82%

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COA HPLC HNMR

GA-017

Catalog No. T60013Cas No. 2351906-74-4

GA-017 is a potent, selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2), exhibiting IC50 values of 4.10 and 3.92 nM, respectively. This compound simultaneously acts as an activator of cell proliferation by promoting YAP/TAZ activation and their nuclear translocation. Additionally, GA-017 enhances cell growth in 3D culture conditions and augments the ex vivo formation of mouse intestinal organoids [1].

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Pack Size	Price	Availability
1 mg	$116	In Stock
5 mg	$289	In Stock
10 mg	$447	In Stock
25 mg	$647	In Stock
50 mg	$987	In Stock
100 mg	$1,330	In Stock
1 mL x 10 mM (in DMSO)	$317	In Stock

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Product Introduction

Bioactivity

Description

In vitro

GA-017 suppresses the HUVECs cell death and promotes their cell growth [1]. GA-017 facilitates SKOV3 cell growth, with an EC 50 of 3.51 ± 0.26 μM [1]. GA-017 competitively inhibited LATS1 and 2 against ATP, with K i (inhibition constant) values of 0.58 ± 0.11 and 0.25 ± 0.03 nM, respectively [1].

Chemical Properties

Molecular Weight	343.38
Formula	C18H21N3O4
Cas No.	2351906-74-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 18.9 mg/mL (55 mM), Sonication and heating to 80℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9122 mL	14.5611 mL	29.1223 mL	145.6113 mL
5 mM	0.5824 mL	2.9122 mL	5.8245 mL	29.1223 mL
10 mM	0.2912 mL	1.4561 mL	2.9122 mL	14.5611 mL
20 mM	0.1456 mL	0.7281 mL	1.4561 mL	7.2806 mL
50 mM	0.0582 mL	0.2912 mL	0.5824 mL	2.9122 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

GA017GA-017GA 017