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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $3,180 | 35 days |
Description | TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A (Ki of 1.2 nM) and Aurora kinase B (Ki of 101 nM), exhibiting antitumor activity. |
Targets&IC50 | Aurora B:101 nM (Ki), Aurora A:1.2 nM (Ki) |
In vivo | In rats, TC-A 2317 hydrochloride (30 mg/kg;p.o.) shows good PK profile; Cmax value is 4930 nM (Tmax=1.2 h) and serum concentration after 24 h is 52 nM (T1/2=3.3 h). In the antitumor mice model, TC-A 2317 hydrochloride is effective without a decrease of body weight[1]. |
Molecular Weight | 392.93 |
Formula | C19H29ClN6O |
Cas No. | 1245907-03-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO: <39 mg/mL Ethanol: <19.50 mg/mL |
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