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Search Results for " permeability "

Targets

236

Compounds

22

Natural Products

140

Recombinant Proteins

4

Libraries

Cat No. Product Name Synonyms Targets
T8844 Diflapolin Others , FLAP , Epoxide Hydrolase
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity.
T4701 Diclofop-methyl Others
Diclofop-methyl is used as the active ingredient in many herbicides that are used to control weed growth in plants such as wheat and wild oats.
T11014 DFP00173 Aquaporin
DFP00173 is a potent and selective aquaporin 3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with IC50 of ~0.1-0.4 μM. Compared with the homologous AQP subtypes AQP7 and AQP9, DFP00173 is selective for AQP3.
T10760 Ceramides Mixture Telomerase
Ceramides Mixture, an endogenous ceramide, consists of hydroxy and non-hydroxy fatty acid-containing ceramides. It is involved in the regulation of cell cycle arrest, growth inhibition, and modulation of telomerase activ...
T2009 SB-3CT MMP
SB-3CT is a potent and specific gelatinase inhibitor for MMP-2(Ki=13.9 nM) and MMP-9(Ki=600 nM).
T8490 Butoconazole 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole Antifungal
Butoconazole (1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole) is an imidazole antifungal agent
T5194 SPHINX31 Serine/threonin kinase
SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50: 5.9 nM).
T2670 ML167 NCGC00188654,CID44968231 DYRK , CDK
ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.
T2456 Tivozanib AV-951,KRN951 VEGFR , PDGFR , Ephrin Receptor
Tivozanib (KRN951) is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities.
T23426 TC-A 2317 hydrochloride Others , Aurora Kinase
TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A with a Ki of 1.2 nM compared to Aurora kinase B with a Ki of 101 nM. TC-A 2317 hydrochloride shows antitumor activity.
T37890L GLP-1(28-36)amide acetate GLP-1(28-36)amide acetate(1225021-13-5 Free base) Antioxidant , Glucagon Receptor
GLP-1(28-36)amide acetate inhibits mitochondrial permeability transition with antioxidant, anti-diabetic and cardioprotection activities.
T19562 Polyethylene glycol 12-hydroxystearate Solutol HS-15 Others
Polyethylene glycol 12-hydroxystearate (Solutol HS-15) is a permeability enhancer.
T15241 ER-000444793 Others , Mitochondrial Metabolism
ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM).
T18988L FITC-Dextran (MW 4000) FITC-Dextran (60842-46-8 MW 4000) Others
FITC-Dextran (MW 4000) is a marker composed of fluorescein isothiocyanate conjugated to 4 kDa dextran, widely used in microcirculation and cell permeability studies.
T7486 Imeglimin hydrochloride EMD 387008 hydrochloride Reactive Oxygen Species , Mitochondrial Metabolism
Imeglimin hydrochloride (EMD 387008 hydrochloride) prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.
T68030 Acitemate Chinoin 123 Others
Acitemate(Chinoin 123) has an inhibitory effect on atherosclerosis and reduces the permeability of the aorta in rabbits fed a hyperlipidemic diet, which can be used to study atherosclerosis.
T77576 17β-HSD10-IN-1 Dehydrogenase , Endogenous Metabolite
17β-HSD10-IN-1 is an orally available 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) inhibitor with blood-brain permeability and potency for the study of Alzheimer's disease.
T41308L Gly-Phe β-naphthylamide acetate Gly-Phe β-naphthylamide acetate(21438-66-4 Free base) Others
Gly-Phe β-naphthylamide acetate is the substrate of Cathepsin C and can be used for research on the function of cathepsin C, intralysosomal hydrolysis and lysosomal membrane permeability.
T1178 Temozolomide NSC 362856,TZM,CCRG 81045,TMZ Apoptosis , DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy
Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic activity, and also induces apoptosis and autophagy.
T10404 ATP synthase inhibitor 1 ATPase
ATP synthase inhibitor 1 is an inhibitor of the c subunit of the F1/FO-ATP synthase complex. It inhibits mitochondrial permeability transition pore (mPTP) opening and does not affect ATP levels.
T15458 H2DCFDA 2',7'-Dichlorodihydrofluorescein diacetate,DCFH-DA Reactive Oxygen Species
H2DCFDA (DCFH-DA) belongs to the class of green fluorescent dyes and is a probe for the detection of intracellular reactive oxygen species (ROS) (Ex/Em=488/525 nm) with cell membrane permeability.
T77042 Aducanumab BIIB037 Beta Amyloid
Aducanumab (BIIB037), A selective human immunoglobulin gamma-1 (IgG1) monoclonal antibody, targets the clustered form of amyloid beta (Aβ). Aducanumab shows brain permeability and may be used to treat Alzheimer's disease...
T0796 Prilocaine hydrochloride Prilocaine HCl,Propitocaine hydrochloride,Xylonest ATPase , Sodium Channel
Prilocaine hydrochloride (Prilocaine HCl) is a local anesthetic of the amino amide type, binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions.
T2274 SC79 SC 79 Akt
SC79 is an AKT agonist with specificity and blood-brain barrier permeability. SC79 specifically binds to the PH domain of AKT, activates cytoplasmic AKT, and inhibits AKT membrane translocation. SC79 has neuroprotective ...
T61969 AChE/BChE-IN-10 AChR , AChE
AChE/BChE-IN-10 is a potent dual inhibitor of AChE and BChE with IC50 values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 exhibits good blood brain barrier permeability. AChE/BChE-IN-10 can inhibit Aβ-aggregation...
T9646 Stafib-2 STAT
Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM, respectively.Stafib-2 has poor cell permeability.
T16684 Puromycin aminonucleoside NSC 3056 Apoptosis , Proteasome , Aminopeptidase , Antibacterial , Antibiotic
Puromycin aminonucleoside (NSC-3056) increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.
T77758 AChE/BuChE-IN-4 AChE
AChE/BuChE-IN-4 is a multi-target AChE/BuChE inhibitor with oral activity and blood-brain barrier permeability, with IC50 values of 2.08 and 7.41 μM for AChE and BuChE, respectively.
T8526 Metformin 1,1-Dimethylbiguanide Mitophagy , AMPK , Autophagy
Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is comm...
T10585 Bozitinib CBT-101,PLB-1001 c-Met/HGFR
Bozitinib (PLB-1001) (PLB-1001) is a highly selective inhibitor of the c-MET kinase with blood-brain barrier permeability. Bozitinib binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily.
T8832 Eledoisin trifluoroacetate (69-25-0 free base) Eledoisin trifluoroacetate Others
Eledoisin trifluoroacetate (69-25-0 free base) is a peptide extracted from the posterior salivary glands of certain small octopi (Eledone spp., Mollusca), or obtained by synthesis. Its actions resemble those of SUBSTANCE...
T8851 I3MT-3 HMPSNE Hippo pathway
I3MT-3 (HMPSNE) (HMPSNE) is a potent, selective and cell membrane permeability inhibitor of 3-mercaptopyruvate sulfur transferase (3MST), which targets the persulfated cysteine residues located at the active site of 3MST...
T61564 PF-03463275 PF-3463275 GlyT
PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.PF-03463275 has CNS permeability and may be used to ameliorate cognitive defici...
T4081 MPTP hydrochloride MPTP-hydrochloride Apoptosis , Dopamine Receptor
MPTP hydrochloride is a precursor of MPP+, a dopamine neurotoxin with blood-brain barrier permeability. MPTP hydrochloride is toxic to dopaminergic neurons, which can lead to Parkinson's disease, and is widely used in th...
T2213 Terconazole Gyno-Terazol,Terazol 3,Terazol 7,Triaconazole,R42470 Antifection , Antifungal
Terconazole (Terazol 7) is a synthetic triazole derivative structurally related to fluconazole, antifungal Terconazole seems to disrupt cell wall synthesis by inhibiting biosynthesis of ergosterol or other sterols, damag...
T19649 PF-06273340 PF 6273340,PF 06273340,PF6273340,PF-6273340 Trk receptor
PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflu...
T10593 BPR1M97 Opioid Receptor
BPR1M97 is a mu opioid receptor (MOP) and neuropeptide-orphin FQ (NOP) receptor agonist with blood-brain barrier permeability and potency, with Kis values of 1.8 nM for MOP and 4.2 nM for NOP.BPR1M97 exhibits anti-injuri...
T6802 CFSE 5(6)-CFDA N-succinmidyl ester,Carboxyfluorescein succinimidyl ester,CFDA-SE,5(6)-Carboxyfluorescein diacetate succinimidyl ester Others
CFSE (CFDA-SE) is a fluorescent dye with cell membrane permeability. CFSE irreversibly binds to intracellular proteins in living cells and is used for the detection of cell proliferation. The labeled cells fluoresce in g...
T18988 FITC-Dextran (MW 10000) FITC-Dextran Others
FITC-Dextran (MW 10000) (FITC-Dextran) is a marker consisting of coupling fluorescein-isothiocyanate to dextran (10 kDa). FITC-Dextran can be used to determine ion, solute, and protein permeability of the blood-brain bar...
T1497 Liranaftate Piritetrate,M-732 Antifungal
Liranaftate (Piritetrate) is a thiocarbamate and squalene epoxidase inhibitor with antifungal activity. Liranaftate inhibits fungal squalene epoxidase, an enzyme that plays a key role in the synthesis of sterol which is ...
TP1095 Elamipretide MTP-131,RX-31,SS-31 Others
Elamipretide (MTP-131) is a mitochondria-targeted antioxidant tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that reduces toxic reactive oxygen species (ROS) production and stabilizes cardiolipin, with blood-brain-barrier ...
T6961 PX-478 PX-478 2HCl HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy
PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-cell function in diabetes mellitus and is used in type 2 di...
T0030 Bupivacaine hydrochloride Vivacaine,Bupivacaine HCl Sodium Channel
Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the vol...
T1438 Butoconazole nitrate RS 35887 Estrogen/progestogen Receptor , Antifungal
Butoconazole Nitrate is the nitrate salt form of butoconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate (RS 35887) interferes with steroid biosynthesis by inhibiting the conversi...
T28165 NF-1819 NF 1819,NF1819 Lipase
NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model ...
T12992 SPR741 acetate SPR741 acetate,NAB741 acetate,SPR741 acetate (1179330-52-9 free base) Antibacterial
SPR741 acetate is a cationic peptide derived from polymyxin B. It exhibits antimicrobial activity against gram-negative bacteria by inhibiting severe gram-negative bacterial sensory by increasing the permeability of the ...
T63505 Tivozanib hydrochloride hydrate
Tivozanib hydrochloride hydrate is a selective, potent, orally active VEGFR tyrosine kinase inhibitor that acts on VEGFR-1 (IC50: 0.21 nM), VEGFR-2 (IC50: 0.16 nM), and VEGFR-3 (IC50: 0.24 nM). Tivozanib hydrochloride hy...
T1435 Praziquantel Pyquiton,Droncit,Biltricide Calcium Channel , Antibiotic , Parasite
Praziquantel (Droncit) increases the permeability of the tegument of susceptible worms, resulting in an influx and increase in intra-tegumental calcium leading to rapid contractions and paralysis of the worm's musculatur...
T6686 Sulconazole mononitrate Exelderm,Sulconazole Nitrate,RS 44872 Antibacterial , Antibiotic , Antifungal
Sulconazole mononitrate (Exelderm) is the nitrate salt form of sulconazole, a synthetic imidazole derivative with the antifungal property. Sulconazole mononitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demeth...
T1115 Doxylamine succinate Decapryn Histamine Receptor
Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate (Decapryn) competitively blocks the histamine H1 receptor and limits the typical allergic and ...

Compounds

Diflapolin
T8844
Synonym:
Target: Others, FLAP, Epoxide Hydrolase
Diclofop-methyl
T4701
Synonym:
Target: Others
DFP00173
T11014
Synonym:
Target: Aquaporin
Ceramides Mixture
T10760
Synonym:
Target: Telomerase
SB-3CT
T2009
Synonym:
Target: MMP
Butoconazole
T8490
Synonym: 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole
Target: Antifungal
SPHINX31
T5194
Synonym:
Target: Serine/threonin kinase
ML167
T2670
Synonym: NCGC00188654,CID44968231
Target: DYRK, CDK
Tivozanib
T2456
Synonym: AV-951,KRN951
Target: VEGFR, PDGFR, Ephrin Receptor
TC-A 2317 hydrochloride
T23426
Synonym:
Target: Others, Aurora Kinase
GLP-1(28-36)amide acetate
T37890L
Synonym: GLP-1(28-36)amide acetate(1225021-13-5 Free base)
Target: Antioxidant, Glucagon Receptor
Polyethylene glycol 12-hydroxystearate
T19562
Synonym: Solutol HS-15
Target: Others
ER-000444793
T15241
Synonym:
Target: Others, Mitochondrial Metabolism
FITC-Dextran (MW 4000)
T18988L
Synonym: FITC-Dextran (60842-46-8 MW 4000)
Target: Others
Imeglimin hydrochloride
T7486
Synonym: EMD 387008 hydrochloride
Target: Reactive Oxygen Species, Mitochondrial Metabolism
Acitemate
T68030
Synonym: Chinoin 123
Target: Others
17β-HSD10-IN-1
T77576
Synonym:
Target: Dehydrogenase, Endogenous Metabolite
Gly-Phe β-naphthylamide acetate
T41308L
Synonym: Gly-Phe β-naphthylamide acetate(21438-66-4 Free base)
Target: Others
Temozolomide
T1178
Synonym: NSC 362856,TZM,CCRG 81045,TMZ
Target: Apoptosis, DNA Alkylator/Crosslinker, DNA/RNA Synthesis, Autophagy
ATP synthase inhibitor 1
T10404
Synonym:
Target: ATPase
H2DCFDA
T15458
Synonym: 2',7'-Dichlorodihydrofluorescein diacetate,DCFH-DA
Target: Reactive Oxygen Species
Aducanumab
T77042
Synonym: BIIB037
Target: Beta Amyloid
Prilocaine hydrochloride
T0796
Synonym: Prilocaine HCl,Propitocaine hydrochloride,Xylonest
Target: ATPase, Sodium Channel
SC79
T2274
Synonym: SC 79
Target: Akt
AChE/BChE-IN-10
T61969
Synonym:
Target: AChR, AChE
Stafib-2
T9646
Synonym:
Target: STAT
Puromycin aminonucleoside
T16684
Synonym: NSC 3056
Target: Apoptosis, Proteasome, Aminopeptidase, Antibacterial, Antibiotic
AChE/BuChE-IN-4
T77758
Synonym:
Target: AChE
Metformin
T8526
Synonym: 1,1-Dimethylbiguanide
Target: Mitophagy, AMPK, Autophagy
Bozitinib
T10585
Synonym: CBT-101,PLB-1001
Target: c-Met/HGFR
Eledoisin trifluoroacetate (69-25-0 free base)
T8832
Synonym: Eledoisin trifluoroacetate
Target: Others
I3MT-3
T8851
Synonym: HMPSNE
Target: Hippo pathway
PF-03463275
T61564
Synonym: PF-3463275
Target: GlyT
MPTP hydrochloride
T4081
Synonym: MPTP-hydrochloride
Target: Apoptosis, Dopamine Receptor
Terconazole
T2213
Synonym: Gyno-Terazol,Terazol 3,Terazol 7,Triaconazole,R42470
Target: Antifection, Antifungal
PF-06273340
T19649
Synonym: PF 6273340,PF 06273340,PF6273340,PF-6273340
Target: Trk receptor
BPR1M97
T10593
Synonym:
Target: Opioid Receptor
CFSE
T6802
Synonym: 5(6)-CFDA N-succinmidyl ester,Carboxyfluorescein succinimidyl ester,CFDA-SE,5(6)-Carboxyfluorescein diacetate succinimidyl ester
Target: Others
FITC-Dextran (MW 10000)
T18988
Synonym: FITC-Dextran
Target: Others
Liranaftate
T1497
Synonym: Piritetrate,M-732
Target: Antifungal
Elamipretide
TP1095
Synonym: MTP-131,RX-31,SS-31
Target: Others
PX-478
T6961
Synonym: PX-478 2HCl
Target: HIF/HIF Prolyl-Hydroxylase, HIF, Autophagy
Bupivacaine hydrochloride
T0030
Synonym: Vivacaine,Bupivacaine HCl
Target: Sodium Channel
Butoconazole nitrate
T1438
Synonym: RS 35887
Target: Estrogen/progestogen Receptor, Antifungal
NF-1819
T28165
Synonym: NF 1819,NF1819
Target: Lipase
SPR741 acetate
T12992
Synonym: SPR741 acetate,NAB741 acetate,SPR741 acetate (1179330-52-9 free base)
Target: Antibacterial
Tivozanib hydrochloride hydrate
T63505
Synonym:
Target:
Praziquantel
T1435
Synonym: Pyquiton,Droncit,Biltricide
Target: Calcium Channel, Antibiotic, Parasite
Sulconazole mononitrate
T6686
Synonym: Exelderm,Sulconazole Nitrate,RS 44872
Target: Antibacterial, Antibiotic, Antifungal
Doxylamine succinate
T1115
Synonym: Decapryn
Target: Histamine Receptor
1 2 3 4 5
Cat No. Product Name Synonyms Targets
T2721 Digitonin Others
Digitonin is a natural product of the glycoside family and is a detergent. Digitonin has antitumor activity, binds to cholesterol molecules to increase the permeability of cell membranes, and is active in the cleavage of...
T15157 Dodecanoylcarnitine Lauroylcarnitine Endogenous Metabolite
Dodecanoylcarnitine ((-)-Lauroylcarnitine) has been associated with disturbances in fatty acid oxidation, and the use of Dodecanoylcarnitine resulted in an increase in the permeability of salmon calcitonin.
TN1990 Norathyriol Akt , DNA/RNA Synthesis , AMPK , PPAR
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
TN1048 Cnidilin Knidilin
Cnidilin (Knidilin) is found in association with Angelica dahurica roots, has high BBB permeability and has pharmacokinetic potential in the treatment of CNS disorders.
TF0083 POPE
POPE is a compound found in Escherichia coli, part of the cell membrane, and can be used to study changes in cell membrane permeability.
T0146 Tioconazole UK-20349,Vagistat Antibiotic , Antifection , Antifungal
Tioconazole (Vagistat) is a synthetic imidazole derivative, inhibits cell wall synthesis by inhibiting the biosynthesis of ergosterol or other sterols, damaging the fungal cell membrane, altering its permeability, and pr...
T8641 Vancomycin Antibacterial , Antibiotic , Autophagy
Vancomycin is a glycopeptide antibiotic that exerts its antimicrobial activity by altering the permeability of cell membranes and selectively inhibiting ribonucleic acid synthesis. Vancomycin can be used for the treatmen...
T13708 Glycol chitosan Antibacterial
Glycol chitosan is a chitosan derivative with hydrophilic ethylene glycol branches. Glycol chitosan inhibits E. coli, S. aureus, and S. enteritidis growths (MICs: 4 μg/mL, 32 μg/mL, and <0.5 μg/mL). It enhances membrane ...
T5S1889 Yunaconitine Guayewuanine B Others
1. Yunaconitine (Guayewuanine B) has anti-inflammatory and analgesic actions. 2. Yunaconitine was shown to have anti-thermic effect in pyrexial rats when administered orally at a dose of 5 μg/kg. 3. Yunaconitine shows po...
T2520 Desloratadine Sch34117,NSC 675447 Endogenous Metabolite , Histamine Receptor
Desloratadine (Sch34117) is a long-acting piperidine derivate with selective H1 antihistaminergic and non-sedating properties. Desloratadine diminishes the typical histaminergic effects on H1-receptors in bronchial smoot...
T14140 Agaric acid Agaricinic Acid Mitochondrial Metabolism , AChR
Agaricic acid is an adenine nucleotide translocase antagonist.It is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus igniarius. Agaric acid (Agaricinic Acid) induces mitochondri...
T3926 Echinatin Retrochalcone Free radical scavengers
Echinatin (Retrochalcone) disturb the mitochondrial energy transfer reactions and membrane permeability, at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liv...
T29888 Aloe-emodin-glucoside
Aloe-emodin-glucoside is a stimulant-laxative which has been shown to enhance colonic membrane permeability of water-soluble and poorly permeable compounds.
TN5575 Coronarin D methyl ether
Coronarin D methyl ether has inhibitory effects on the increase in vascular permeability, nitric oxide production, and inducible nitric oxide synthase induction.
T40910 Cognac oil
Cognac oil, predominantly derived from wine lees, exhibits distinctive fatty acid compositions, characterized by high proportions of Palmitic acid (59.26%), Linoleic acid (11.92%), Myristic acid (8.97%), and Oleic acid (...
TN6198 Mahanine
Mahanine has effects on the activation of the apoptotic pathway in human leukemia U937 cells, causes the mitochondrial membranes to lose their permeability, resulting in caspase-3 activation and apoptosis. Mahanine can r...
TN4475 Macrocarpal C ROS , Antifection
Macrocarpal C, isolated from the fresh leaves of Eucalyptus globulus Labill. (Lan An) and identified as its major antifungal component by bioassay-guided purification, the antifungal action of macrocarpal C was associate...
TN2160 Roemerine (-)-Roemerine Antibiotic
Roemerine ((-)-Roemerine) is a porphyrin alkaloid from Senegalese lychee with antifungal and anticancer activity that prevents berberine efflux through inhibition of Bmr. Roemerine increases cell membrane permeability in...
TN3914 Echinatine ATPase , IL Receptor , TNF
Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and anti-inflammatory activities of this compound. Echinatin c...
T75967 Bactenecin TFA
Bactenecin TFA (Bactenecin, bovine TFA), a potent 12-aa looped antimicrobial peptide derived from bovine neutrophils, effectively inhibits bacterial and yeast growth and eradicates Trichophyton rubrum fungus. It enhances...
TN2945 3-Hydroxybakuchiol ATPase , Caspase
3-Hydroxybakuchiol exerts cytotoxic and anti-proliferative effects on the TA3/Ha mouse mammary adenocarcinoma cell line and induces a decrease in the mitochondrial transmembrane potential, the activation of caspase-3, th...
T37810 6',7'-Epoxybergamottin
6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, a...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-00865 VEGF121 Protein, Human, Recombinant (His) Human Human Cells
Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PD...
TMPY-02908 BPI Protein, Human, Recombinant (His) Human HEK293
Bactericidal/permeability-increasing protein is a member of the BPI/LBP/Plunc superfamily and BPI/LBP family. It is a cationic protein which can be detected in the azurophilic granule and on the surface of polymorphonucl...
TMPJ-00412 VEGFR1/FLT-1 Protein, Human, Recombinant (hFc) Human Human Cells
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 ...
TMPY-02432 VEGF164 Protein, Rat, Recombinant Rat Baculovirus-Insect Cells
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-...
TMPY-01717 VEGF164 Protein, Mouse, Recombinant Mouse Baculovirus-Insect Cells
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-...
TMPY-03698 VEGF121b Protein, Human, Recombinant Human HEK293
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-...
TMPY-04911 VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated Human,Cynomolgus HEK293
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-...
TMPK-00823 VEGF165 Protein, Human, Recombinant (His & Avi) Human HEK293
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most a...
TMPJ-00864 VEGF165 Protein, Human, Recombinant Human Human Cells
Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator...
TMPY-02533 IGFBP-7 Protein, Human, Recombinant (aa 30-282, His) Human HEK293
Insulin-like growth factor-binding protein 7 (IGFBP7) is a member of the IGFBP family. It has been identified in colorectal adenocarcinoma (CRC) cell lines. The Insulin-like growth factor-binding protein also known as IG...
TMPY-02295 IGFBP-7 Protein, Human, Recombinant (aa 1-282, hFc) Human HEK293
Insulin-like growth factor-binding protein 7 (IGFBP7) is a member of the IGFBP family. It has been identified in colorectal adenocarcinoma (CRC) cell lines. The Insulin-like growth factor-binding protein also known as IG...
TMPY-04508 IGFBP-7 Protein, Mouse, Recombinant (aa 1-281, hFc) Mouse HEK293
Insulin-like growth factor-binding protein 7 (IGFBP7) is a member of the IGFBP family. It has been identified in colorectal adenocarcinoma (CRC) cell lines. The Insulin-like growth factor-binding protein also known as IG...
TMPY-04935 CD47 Protein, Human, Recombinant (aa 1-139, His) Human HEK293
CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a mem...
TMPY-05343 CD47 Protein, Cynomolgus, Rhesus, Recombinant (His) Cynomolgus,Rhesus HEK293
CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a mem...
TMPY-02700 BCL2 Protein, Human, Recombinant (His) Human E. coli
BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family a...
TMPY-00639 EPO/Erythropoietin Protein, Human, Recombinant (hFc) Human HEK293
Erythropoietin is a member of the EPO / TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. Erythropoietin can be found in the plasma and regulates red cell production by promoting...
TMPY-00443 EPO/Erythropoietin Protein, Mouse, Recombinant Mouse HEK293
Erythropoietin is a member of the EPO / TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. Erythropoietin can be found in the plasma and regulates red cell production by promoting...
TMPY-04683 CD47 Protein, Human, Recombinant Human HEK293
CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a mem...
TMPY-03093 CD47 Protein, Rat, Recombinant (His) Rat HEK293
CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a mem...
TMPY-05191 CD47 Protein, Human, Recombinant, Biotinylated Human HEK293
CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a mem...
TMPY-05276 CD47 Protein, Cynomolgus, Recombinant (hFc) Cynomolgus HEK293
CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a mem...
TMPY-04810 CD47 Protein, Mouse, Recombinant (His) Mouse HEK293
CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a mem...
TMPY-00637 FLT1 Protein, Human, Recombinant (aa 1-328, His) Human HEK293
Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a si...
TMPY-00836 IGFBP-4 Protein, Human, Recombinant (His) Human HEK293
Insulin-like growth factor-binding protein 4 (IGFBP-4) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-bin...
TMPY-04815 C1 inhibitor Protein, Rat, Recombinant (His) Rat HEK293
Plasma protease C1 inhibitor, also known as C1-inhibiting factor, C1-INH, C1 esterase inhibitor, SERPING1 and C1IN, is a serine proteinase inhibitor (serpin) that regulates activation of both the complement and contact s...
TMPY-02118 IGFBP-6 Protein, Mouse, Recombinant (His) Mouse HEK293
Insulin-like growth factor-binding protein 6 (IGFBP6) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-bind...
TMPY-00853 IL-1RA Protein, Human, Recombinant Human E. coli
Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A), and interleukin 1, beta (IL1B), and mo...
TMPY-05057 Complement C5 Protein, Human, Recombinant (His & FLAG) Human HEK293
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPY-04902 Complement C5a Protein, Mouse, Recombinant Mouse E. coli
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPY-00653 Complement C5 Protein, Human, Recombinant (Complement C5a) Human E. coli
C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathway...
TMPY-03705 VEGF164 Protein, Canine, Recombinant Canine HEK293
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-...
TMPY-01656 VEGF183 Protein, Human, Recombinant Human Baculovirus-Insect Cells
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-...
TMPY-05798 VEGF145 Protein, Human, Recombinant Human HEK293
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-...
TMPY-03080 VEGF165 Protein, Danio rerio (zebrafish), Recombinant Danio rerio (zebrafish) Baculovirus-Insect Cells
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-...
TMPH-03703 Zot Protein, Vibrio cholerae serotype O1, Recombinant (His) Vibrio cholerae E. coli
Increases the permeability of the small intestine mucosa by affecting the structure of intercellular tight junctions (zonula occludens).
TMPK-00834 CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, His) Human HEK293
Platelet endothelial cell adhesion molecule 1 (PECAM-1) is an adhesion and signaling receptor that is expressed on endothelial and hematopoietic cells and plays important roles in angiogenesis, vascular permeability, and...
TMPH-02523 AQP2 Protein, Mouse, Recombinant (His) Mouse in vitro E. coli expression system
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential rol...
TMPK-00562 CD31/PECAM-1 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Platelet endothelial cell adhesion molecule 1 (PECAM-1) is an adhesion and signaling receptor that is expressed on endothelial and hematopoietic cells and plays important roles in angiogenesis, vascular permeability, and...
TMPK-00833 CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, hFc) Human HEK293
Platelet endothelial cell adhesion molecule 1 (PECAM-1) is an adhesion and signaling receptor that is expressed on endothelial and hematopoietic cells and plays important roles in angiogenesis, vascular permeability, and...
TMPK-00825 VEGF121 Protein, Human, Recombinant (His & Avi) Human HEK293
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most a...
TMPK-00822 VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled Human HEK293
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most a...
TMPH-00674 OmpA Protein, E. coli O157:H7, Recombinant (His & SUMO) E. coli E. coli
With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows dow...
TMPH-03246 AQP2 Protein, Rat, Recombinant (His) Rat in vitro E. coli expression system
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential rol...
TMPK-00661 IL-22 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeab...
TMPK-01194 IL-22 Protein, Mouse, Recombinant (His & Avi), Biotinylated Mouse E. coli
The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeab...
TMPH-01751 Nephrin/NPHS1 Protein, Human, Recombinant (His) Human E. coli
Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role ...
TMPH-00782 OMP P5 Protein, Haemophilus influenzae, Recombinant (His & Myc & SUMO) Haemophilus influenzae E. coli
Acts as a fimbriae subunit, allowing adhesion to host cells.; With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows...
TMPK-01201 BPIFA1/LUNX Protein, Human, Recombinant Human E. coli
Bactericidal/permeability-increasing fold containing family A, member 1 (BPIFA1) is a secretory protein found in human upper aerodigestive tract mucosa. This innate material is secreted in mucosal fluid or found in submu...
TMPK-00826 VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most a...
TMPH-00031 Aerolysin Protein, Aeromonas sobria, Recombinant (His & Myc) Aeromonas sobria E. coli
Secreted, cytolytic toxin that forms pores in host membranes after proteolytic removal of a C-terminal propeptide, leading to destruction of the membrane permeability barrier and cell death. The pores are formed by trans...
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VEGF121 Protein, Human, Recombinant (His)
TMPJ-00865
Species: Human
Expression System: Human Cells
BPI Protein, Human, Recombinant (His)
TMPY-02908
Species: Human
Expression System: HEK293
VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)
TMPJ-00412
Species: Human
Expression System: Human Cells
VEGF164 Protein, Rat, Recombinant
TMPY-02432
Species: Rat
Expression System: Baculovirus-Insect Cells
VEGF164 Protein, Mouse, Recombinant
TMPY-01717
Species: Mouse
Expression System: Baculovirus-Insect Cells
VEGF121b Protein, Human, Recombinant
TMPY-03698
Species: Human
Expression System: HEK293
VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPY-04911
Species: Human,Cynomolgus
Expression System: HEK293
VEGF165 Protein, Human, Recombinant (His & Avi)
TMPK-00823
Species: Human
Expression System: HEK293
VEGF165 Protein, Human, Recombinant
TMPJ-00864
Species: Human
Expression System: Human Cells
IGFBP-7 Protein, Human, Recombinant (aa 30-282, His)
TMPY-02533
Species: Human
Expression System: HEK293
IGFBP-7 Protein, Human, Recombinant (aa 1-282, hFc)
TMPY-02295
Species: Human
Expression System: HEK293
IGFBP-7 Protein, Mouse, Recombinant (aa 1-281, hFc)
TMPY-04508
Species: Mouse
Expression System: HEK293
CD47 Protein, Human, Recombinant (aa 1-139, His)
TMPY-04935
Species: Human
Expression System: HEK293
CD47 Protein, Cynomolgus, Rhesus, Recombinant (His)
TMPY-05343
Species: Cynomolgus,Rhesus
Expression System: HEK293
BCL2 Protein, Human, Recombinant (His)
TMPY-02700
Species: Human
Expression System: E. coli
EPO/Erythropoietin Protein, Human, Recombinant (hFc)
TMPY-00639
Species: Human
Expression System: HEK293
EPO/Erythropoietin Protein, Mouse, Recombinant
TMPY-00443
Species: Mouse
Expression System: HEK293
CD47 Protein, Human, Recombinant
TMPY-04683
Species: Human
Expression System: HEK293
CD47 Protein, Rat, Recombinant (His)
TMPY-03093
Species: Rat
Expression System: HEK293
CD47 Protein, Human, Recombinant, Biotinylated
TMPY-05191
Species: Human
Expression System: HEK293
CD47 Protein, Cynomolgus, Recombinant (hFc)
TMPY-05276
Species: Cynomolgus
Expression System: HEK293
CD47 Protein, Mouse, Recombinant (His)
TMPY-04810
Species: Mouse
Expression System: HEK293
FLT1 Protein, Human, Recombinant (aa 1-328, His)
TMPY-00637
Species: Human
Expression System: HEK293
IGFBP-4 Protein, Human, Recombinant (His)
TMPY-00836
Species: Human
Expression System: HEK293
C1 inhibitor Protein, Rat, Recombinant (His)
TMPY-04815
Species: Rat
Expression System: HEK293
IGFBP-6 Protein, Mouse, Recombinant (His)
TMPY-02118
Species: Mouse
Expression System: HEK293
IL-1RA Protein, Human, Recombinant
TMPY-00853
Species: Human
Expression System: E. coli
Complement C5 Protein, Human, Recombinant (His & FLAG)
TMPY-05057
Species: Human
Expression System: HEK293
Complement C5a Protein, Mouse, Recombinant
TMPY-04902
Species: Mouse
Expression System: E. coli
Complement C5 Protein, Human, Recombinant (Complement C5a)
TMPY-00653
Species: Human
Expression System: E. coli
VEGF164 Protein, Canine, Recombinant
TMPY-03705
Species: Canine
Expression System: HEK293
VEGF183 Protein, Human, Recombinant
TMPY-01656
Species: Human
Expression System: Baculovirus-Insect Cells
VEGF145 Protein, Human, Recombinant
TMPY-05798
Species: Human
Expression System: HEK293
VEGF165 Protein, Danio rerio (zebrafish), Recombinant
TMPY-03080
Species: Danio rerio (zebrafish)
Expression System: Baculovirus-Insect Cells
Zot Protein, Vibrio cholerae serotype O1, Recombinant (His)
TMPH-03703
Species: Vibrio cholerae
Expression System: E. coli
CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, His)
TMPK-00834
Species: Human
Expression System: HEK293
AQP2 Protein, Mouse, Recombinant (His)
TMPH-02523
Species: Mouse
Expression System: in vitro E. coli expression system
CD31/PECAM-1 Protein, Cynomolgus, Recombinant (His)
TMPK-00562
Species: Cynomolgus
Expression System: HEK293
CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, hFc)
TMPK-00833
Species: Human
Expression System: HEK293
VEGF121 Protein, Human, Recombinant (His & Avi)
TMPK-00825
Species: Human
Expression System: HEK293
VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled
TMPK-00822
Species: Human
Expression System: HEK293
OmpA Protein, E. coli O157:H7, Recombinant (His & SUMO)
TMPH-00674
Species: E. coli
Expression System: E. coli
AQP2 Protein, Rat, Recombinant (His)
TMPH-03246
Species: Rat
Expression System: in vitro E. coli expression system
IL-22 Protein, Cynomolgus, Recombinant (His)
TMPK-00661
Species: Cynomolgus
Expression System: HEK293
IL-22 Protein, Mouse, Recombinant (His & Avi), Biotinylated
TMPK-01194
Species: Mouse
Expression System: E. coli
Nephrin/NPHS1 Protein, Human, Recombinant (His)
TMPH-01751
Species: Human
Expression System: E. coli
OMP P5 Protein, Haemophilus influenzae, Recombinant (His & Myc & SUMO)
TMPH-00782
Species: Haemophilus influenzae
Expression System: E. coli
BPIFA1/LUNX Protein, Human, Recombinant
TMPK-01201
Species: Human
Expression System: E. coli
VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00826
Species: Human
Expression System: HEK293
Aerolysin Protein, Aeromonas sobria, Recombinant (His & Myc)
TMPH-00031
Species: Aeromonas sobria
Expression System: E. coli
Cat No. Product Name
L1500 GPCR Compound Library

1940 compounds
A unique collection of 1940 GPCR-active agents for high throughput screening and high content screening for GPCR drug discovery, and new GPCR target identification and research;
L7200 Calcium Channel Compound Library

143 compounds
A unique collection of 143 calcium channel blockers and agonists for high throughput and high content screening;
L5100 Fluorochemical Library

583 compounds
A unique collection of 583 fluorochemicals that can be used for high through-put screening (HTS) and high content screening (HCS);
L9300 Macrocyclic Compound Library

216 compounds
216 macrocyclic compounds of known activity for high-throughput, high-content screening;
TargetMol