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Methylnaltrexone iodide
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Catalog No. T40845Cas No. 73232-53-8
Alias Naltrexonium methiodide
Methylnaltrexone iodide, a quaternary derivative of Naltrexone, is an orally active and selective antagonist of the mu-opioid receptor. It acts peripherally in the gastrointestinal tract to antagonize the receptor and exhibits limited permeability across the blood-brain barrier.
Methylnaltrexone iodide
😃Good
Catalog No. T40845Alias Naltrexonium methiodideCas No. 73232-53-8
Methylnaltrexone iodide, a quaternary derivative of Naltrexone, is an orally active and selective antagonist of the mu-opioid receptor. It acts peripherally in the gastrointestinal tract to antagonize the receptor and exhibits limited permeability across the blood-brain barrier.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $970 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Methylnaltrexone iodide, a quaternary derivative of Naltrexone, is an orally active and selective antagonist of the mu-opioid receptor. It acts peripherally in the gastrointestinal tract to antagonize the receptor and exhibits limited permeability across the blood-brain barrier. |
| In vivo | At a dosage of 2.0 mg/kg, Methylnaltrexone iodide, when injected into morphine-induced male Albino Hartley strain guinea pigs, effectively returned the number of coughs to baseline levels without affecting nociception [2]. |
| Alias | Naltrexonium methiodide |
| Molecular Weight | 483.346 |
| Formula | C21H26INO4 |
| Cas No. | 73232-53-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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