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Methylnaltrexone iodide

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Catalog No. T40845Cas No. 73232-53-8
Alias Naltrexonium methiodide

Methylnaltrexone iodide, a quaternary derivative of Naltrexone, is an orally active and selective antagonist of the mu-opioid receptor. It acts peripherally in the gastrointestinal tract to antagonize the receptor and exhibits limited permeability across the blood-brain barrier.

Methylnaltrexone iodide

Methylnaltrexone iodide

😃Good
Catalog No. T40845Alias Naltrexonium methiodideCas No. 73232-53-8
Methylnaltrexone iodide, a quaternary derivative of Naltrexone, is an orally active and selective antagonist of the mu-opioid receptor. It acts peripherally in the gastrointestinal tract to antagonize the receptor and exhibits limited permeability across the blood-brain barrier.
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Product Introduction

Bioactivity
Description
Methylnaltrexone iodide, a quaternary derivative of Naltrexone, is an orally active and selective antagonist of the mu-opioid receptor. It acts peripherally in the gastrointestinal tract to antagonize the receptor and exhibits limited permeability across the blood-brain barrier.
In vivo
At a dosage of 2.0 mg/kg, Methylnaltrexone iodide, when injected into morphine-induced male Albino Hartley strain guinea pigs, effectively returned the number of coughs to baseline levels without affecting nociception [2].
AliasNaltrexonium methiodide
Chemical Properties
Molecular Weight483.346
FormulaC21H26INO4
Cas No.73232-53-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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