Shopping Cart

Remove All
Your shopping cart is currently empty

AChE/BuChE/MAO-B-IN-2

Name: AChE/BuChE/MAO-B-IN-2
Brand: TargetMol
SKU: T78679
Price: 34 USD
Availability: InStock
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T78679

AChE/BuChE/MAO-B-IN-2 (compound 4b) is a potent inhibitor of AChE, BuChE, and hu MAO-B, with respective IC50 values of 5.3 μM, 12.4 μM, and 1.9±0.08 μM, indicating good in vitro blood-brain barrier (BBB) permeability. It effectively reduces excessive AChE and BuChE levels associated with Alzheimer's disease (AD) and holds potential for anti-Alzheimer's research [1].

AChE/BuChE/MAO-B-IN-2

😃Good

Catalog No. T78679

Pack Size	Price	Availability	Quantity
5 mg	Inquiry	Backorder
50 mg	Inquiry	Backorder

Bulk & Custom

Add to Cart

Questions

Resource Download

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	AChE/BuChE/MAO-B-IN-2 (compound 4b) is a potent inhibitor of AChE, BuChE, and hu MAO-B, with respective IC50 values of 5.3 μM, 12.4 μM, and 1.9±0.08 μM, indicating good in vitro blood-brain barrier (BBB) permeability. It effectively reduces excessive AChE and BuChE levels associated with Alzheimer's disease (AD) and holds potential for anti-Alzheimer's research [1].
Targets&IC50	MAO-B (human):1.9 μM, BChE:12.4 μM, AChE:5.3 μM
In vitro	Compound 4b (AChE/BuChE/MAO-B-IN-2) at concentrations of 5, 10, 20 μmol/L for 2 hours, exhibited significant neuroprotective effects against Aβ1-42-induced damage in PC12 cells [1]. Additionally, when incubated at 1 mg/mL in simulated gastric/intestinal fluid, plasma, and rat liver microsomes, AChE/BuChE/MAO-B-IN-2 demonstrated good stability over time periods of 0, 0.5, 1, 1.5, 2, and 3 hours [1].
In vivo	AChE/BuChE/MAO-B-IN-2 (compound 4b), at concentrations of 0.0049, 0.0195, and 0.078 μg/mL with a 10-minute treatment, significantly ameliorated motor dysfunction and improved responsiveness in a zebrafish Alzheimer's disease model induced by ACAL 3 [1].

Chemical Properties

Molecular Weight	327.35
Formula	C₁₉H₁₈FNO₃

Storage & Solubility Information

Storage

Shipping with blue ice.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc