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Bupivacaine hydrochloride
🥰Excellent
Catalog No. T0030Cas No. 18010-40-7
Alias Vivacaine, Bupivacaine HCl
Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to sodium ions and membrane stabilization; inhibition of depolarization and nerve impulse conduction; and a reversible loss of sensation.
Bupivacaine hydrochloride
🥰Excellent
Purity: 100%
Catalog No. T0030Alias Vivacaine, Bupivacaine HClCas No. 18010-40-7
Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to sodium ions and membrane stabilization; inhibition of depolarization and nerve impulse conduction; and a reversible loss of sensation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 mg | $35 | In Stock | |
| 200 mg | $39 | In Stock | |
| 500 mg | $53 | In Stock | |
| 1 g | $77 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to sodium ions and membrane stabilization; inhibition of depolarization and nerve impulse conduction; and a reversible loss of sensation. |
| In vitro | Bupivacaine can induce calcium release from the sarcoplasmic reticulum (SR) in rats and suppress the SR's uptake of calcium. |
| In vivo | In vitro, Bupivacaine exhibits cytotoxic effects on bovine articular chondrocytes after an exposure of 15 to 30 minutes. It acts on isolated mitochondria as an uncoupler of oxygen consumption and adenosine diphosphate phosphorylation. Concentration-dependent mitochondrial depolarization and pyridine nucleotide oxidation are induced by Bupivacaine in these isolated mitochondria. Additionally, Bupivacaine triggers the opening of the permeability transition pore (PTP), a cyclosporin A-sensitive inner membrane channel pivotal in various forms of cell death. |
| Alias | Vivacaine, Bupivacaine HCl |
| Molecular Weight | 324.89 |
| Formula | C18H28N2O·HCl |
| Cas No. | 18010-40-7 |
| Smiles | Cl.CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 16.67 mg/mL (51.3 mM)  H2O: 21 mg/mL (64.6 mM) Ethanol: 60 mg/mL (184.7 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO/H2O/Ethanol
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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