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Bupivacaine

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Purity:100%

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COA HNMR HPLC

Bupivacaine

Catalog No. T0030LCas No. 38396-39-3

Bupivacaine (AH-250) is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain.

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Pack Size	Price	Availability
50 mg	$33	In Stock
100 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock

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Product Introduction

Bioactivity

Description	Bupivacaine (AH-250) is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain.
In vitro	Bupivacaine inhibits NMDA receptor-mediated synaptic transmission in the dorsal horn of the spinal cord, a key area in central sensitization[1]. It affects the voltage dependency of channel activation and steady-state inactivation by shifting the membrane potential of half-maximal activation/inactivation toward more negative potentials. SCN5A channels are slightly sensitive to Bupivacaine in their inactivated state (IC50=2.18±0.16 μM)[2]. Additionally, Bupivacaine reversibly inhibits the SK2 channel in a dose-dependent manner with an IC50 of 16.5 µM[3].
Alias	AH 250, AH-250, AH250, Bupivacaina, Exparel, Anekain

Chemical Properties

Molecular Weight	288.43
Formula	C18H28N2O
Cas No.	38396-39-3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 25 mg/mL (86.69 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4670 mL	17.3352 mL	34.6705 mL	173.3523 mL
5 mM	0.6934 mL	3.4670 mL	6.9341 mL	34.6705 mL
10 mM	0.3467 mL	1.7335 mL	3.4670 mL	17.3352 mL
20 mM	0.1734 mL	0.8668 mL	1.7335 mL	8.6676 mL
50 mM	0.0693 mL	0.3467 mL	0.6934 mL	3.4670 mL

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