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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $33 | In Stock | |
100 mg | Inquiry | In Stock | |
1 mL x 10 mM (in DMSO) | $52 | In Stock |
Description | Bupivacaine (AH-250) is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain. |
In vitro | Bupivacaine inhibits NMDA receptor-mediated synaptic transmission in the dorsal horn of the spinal cord, a key area in central sensitization[1]. It affects the voltage dependency of channel activation and steady-state inactivation by shifting the membrane potential of half-maximal activation/inactivation toward more negative potentials. SCN5A channels are slightly sensitive to Bupivacaine in their inactivated state (IC50=2.18±0.16 μM)[2]. Additionally, Bupivacaine reversibly inhibits the SK2 channel in a dose-dependent manner with an IC50 of 16.5 µM[3]. |
Alias | AH 250, AH-250, AH250, Bupivacaina, Exparel, Anekain |
Molecular Weight | 288.43 |
Formula | C18H28N2O |
Cas No. | 38396-39-3 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 25 mg/mL (86.69 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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