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Polymyxin B nonapeptide

Catalog No. TP1341Cas No. 86408-36-8

Polymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probably by binding to the bacterial lipopolysaccharide (LPS)

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Pack Size	Price	Availability
5 mg	$121	Backorder
10 mg	$207	Backorder
50 mg	$783	Backorder
100 mg	$1,190	Backorder

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	963.13
Formula	C43H74N14O11
Cas No.	86408-36-8

Storage & Solubility Information

Storage

keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 100 mg/mL (103.83 mM)

DMSO: 16.67 mg/mL (17.31 mM)

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0383 mL	5.1914 mL	10.3828 mL	51.9141 mL
5 mM	0.2077 mL	1.0383 mL	2.0766 mL	10.3828 mL
10 mM	0.1038 mL	0.5191 mL	1.0383 mL	5.1914 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.0519 mL	0.2596 mL	0.5191 mL	2.5957 mL
50 mM	0.0208 mL	0.1038 mL	0.2077 mL	1.0383 mL
100 mM	0.0104 mL	0.0519 mL	0.1038 mL	0.5191 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc