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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $97 | In Stock | |
10 mg | $161 | In Stock | |
25 mg | $324 | In Stock | |
50 mg | $537 | In Stock | |
100 mg | $649 | In Stock | |
500 mg | $1,380 | In Stock | |
1 mL x 10 mM (in DMSO) | $86 | In Stock |
Description | PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor. |
In vivo | Treated pregnant dams with the CSF1R inhibitor PLX-5622. Approximately 99% of microglia were eliminated by embryonic day 15.5 (E15.5) after pregnant dams were placed on a PLX-5622 diet starting at E3.5. Following microglia depletion, Elevated numbers of apoptotic cells accumulating throughout the developing hypothalamus. Once the PLX-5622 diet was removed, microglia repopulated the postnatal brain within 7?days and did not appear to repopulate from Nestin+?precursors[1]. |
Alias | PLX-5622 |
Molecular Weight | 395.41 |
Formula | C21H19F2N5O |
Cas No. | 1303420-67-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 16.67 mg/mL (42.15 mM) ![]() | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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