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Cytokine Inhibitor Library

Catalog No. L3600
  Library Compound List   Excel SDF

Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling, modulate the balance between humoral and cell-based immune responses, and are heavily involved in autoimmune and inflammatory diseases. Blocking cytokine signaling pathways by biologics has shown clinical effectiveness in these diseases.

Cytokines act through receptors and activate related signaling to modulate gene expression and cell functions. Cytokine receptors activate many signaling pathways: JAK-STAT, NF-kB, MAPK, PI3K, etc. A number of small molecular weight inhibitors targeting cytokine signaling have been identified as research progresses and some are approved to be marketed. Cytokines Inhibitors Library from TargetMol, containing 613 compounds targeting cytokine signaling, can be used for high throughput and high content screening for drug discovery.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • A unique collection of 613 compounds targeting cytokine signaling for high throughput screening and high content screening for drug discovery;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and most of them are approved to be marketed;
  • Targets cover various cytokines including IL, CSF, IFN, TNF, TGF-beta family, growth factors, chemokine family, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L3600)

Library Composition

VEGFR (132)
EGFR (131)
TNF (81)
Apoptosis (80)
PDGFR (79)
FGFR (72)
Autophagy (61)
IL Receptor (60)
c-Kit (54)
TGF-beta/Smad (49)
c-Met/HGFR (47)
FLT (44)
Src (33)
CXCR (31)
NF-κB (30)
CCR (29)
Interleukin (28)
ALK (27)
IGF-1R (27)
HER (26)
Bcr-Abl (22)
c-RET (19)
JAK (17)
COX (16)
Endogenous Metabolite (16)
c-Fms (16)
HIV Protease (15)
Raf (14)
Antibacterial (14)
TAM Receptor (13)
RIP kinase (12)
Potassium Channel (12)
CDK (12)
CSF-1R (11)
Aurora Kinase (9)
p38 MAPK (9)
IFNAR (8)
STAT (8)
Tyrosine Kinases (8)
ERK (8)
Drug Metabolite (7)
FAK (7)
Parasite (7)
Trk receptor (7)
Ferroptosis (6)
NO Synthase (6)
5-HT Receptor (6)
DNA/RNA Synthesis (6)
BTK (6)
Reactive Oxygen Species (6)
Tyrosinase (6)
MEK (5)
JNK (5)
Influenza Virus (5)
Akt (5)
PKC (5)
ROS (5)
IκB/IKK (5)
PDE (5)
Caspase (5)
P450 (4)
PI3K (4)
TLR (4)
PKA (4)
Sodium Channel (4)
S6 Kinase (4)
Chk (4)
MMP (4)
MLK (4)
Ephrin Receptor (4)
NOD (4)
Virus Protease (3)
Mitophagy (3)
AMPK (3)
STING (3)
Anti-infection (3)
Tie-2 (3)
NOS (3)
PPAR (3)
Discoidin Domain Receptor (DDR) (3)
HCV Protease (3)
NOD-like Receptor (NLR) (3)
Calcium Channel (3)
GSK-3 (3)
PLK (2)
Mitochondrial Metabolism (2)
mTOR (2)
P-gp (2)
MAPK (2)
Syk (2)
transporter (2)
PYK2 (2)
IRE1 (2)
Histamine Receptor (2)
GABA Receptor (2)
Hck (2)
Antifungal (2)
HDAC (2)
Chloride channel (2)
Casein Kinase (2)
Adrenergic Receptor (2)
ROCK (1)
c-Myc (1)
ROR (1)
Reverse Transcriptase (1)
CFTR (1)
Dehydrogenase (1)
SARS-CoV (1)
Serine Protease (1)
SGK (1)
SGLT (1)
Sirtuin (1)
DNA Alkylation (1)
cell cycle arrest (1)
LTR (1)
Proton pump (1)
Antibiotic (1)
AChR (1)
ACK (1)
VDA (1)
Adenosine Receptor (1)
TRP/TRPV Channel (1)
Annexin A (1)
Topoisomerase (1)
CaMK (1)
Antifection (1)
Antioxidant (1)
Antiviral (1)
ATPase (1)
BCL (1)
Beta Amyloid (1)
E1/E2/E3 Enzyme (1)
Epigenetic Reader Domain (1)
Prostaglandin Receptor (1)
AChE (1)
Indoleamine 2,3-Dioxygenase (IDO) (1)
Integrin (1)
NAMPT (1)
NADPH-oxidase (1)
NADPH (1)
Na+/Ca2+ Exchanger (1)
MRP (1)
HSP (1)
MNK (1)
LDL (1)
Leukotriene Receptor (1)
Lipase (1)
Lipoxygenase (1)
Microtubule Associated (1)
iGluR (1)
Histone Acetyltransferase (1)
Progesterone Receptor (1)
Phospholipase (1)
LRRK2 (1)
Estrogen Receptor/ERR (1)
Estrogen/progestogen Receptor (1)
PKM (1)
FAAH (1)
Gap Junction Protein (1)
Glucocorticoid Receptor (1)
HIF/HIF Prolyl-Hydroxylase (1)
PGE Synthase (1)
PDK (1)
Glucokinase (1)
HBV (1)
PARP (1)
PAD (1)
Wnt/beta-catenin (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE